I've heard that Foroskolin might help with tanning, any experiences with that?
Thread: Forskolin for tanning?
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03-24-2009, 12:22 PM #10
In order ot metabolize into melanin, tyrosine needs to interact with:
By Rachael Myers Lowe, cancerpage.com
(September 21, 2006) - Researchers in Boston have developed a cream that causes the skin to tan. So far, it?s only been tested on mice and Dr. David E. Fisher of the Dana Farber Cancer Institute cautions that tests on humans are still a couple of years away.
The research is published in the September 21 issue of the journal Nature.
"The goal of the study," Dr. Fisher told cancerpage.com, " was to understand mechanistically how ultraviolet (UV) radiation induces skin darkening, what we know as the tanning process."
"We stumbled across a surprising discovery," he said.
The UV radiation didn?t appear to be acting directly on the pigment cells - the melanocytes ? that darken the skin but rather acted indirectly by stimulating the production of a hormone that attaches to the pigment cells and begins a series of chemical changes that lead to skin tanning. In the fair-skinned mice this hormone couldn?t attach and the chemical chain-reaction was stopped in its tracks.
The researchers then sought to bypass that step ? to stimulate the chemical chain-reaction further downstream. The first compound they tested - forskolin ? worked and it worked without the need for UV rays. The drug stimulated the same tanning pathway but started downstream from the blockage in fair-skinned mice.
Unlike the sunless tanning lotions available on the market today that dye the skin the forskolin lotion stimulated the natural tanning process.
"The drug that we?re using is not a coloring agent per se, rather it?s stimulating the melanocytes in a fashion exactly mimicking the very same pathway the tanning response would stimulate," Dr. Fisher said.
PROTECTIVE AS WELL
There was a benefit in the forskolin-induced tanning.
"The darkening is very profound and functional in the sense that it protected against UV radiation," Dr. Fisher said.
In tests designed to mimic an hour of noontime sun exposure in Florida, the forskolin-darkened mice were protected against sunburn and against the genetic damage that can lead to skin cancer. But human skin is not mouse skin. For one thing, it?s considerably thicker than mouse skin so the cream may not penetrate as well.
This research is many years away from producing a cream for humans.
"Forskolin is the first drug we attempted, but I don?t believe that it will necessarily be the best drug for humans. It?s almost never the case that the first one you try is the best one," Dr. Fisher said.
Forskolin creams are not approved for sale in the United States although the homeopathic product is available in pill form. But Dr. Fisher warns there?s no reason to believe digested forskolin would have the same effect on the skin.
"This is by no means an advertisement for people to go out and start putting this on their skins [?] When there are things that are biologically active and we don?t understand them I am not in favor of people experimenting," Dr. Fisher said.
Nature September 21, 2006.
Cancerpage.com telephone interview with Dr. David E. Fisher on September 19, 2006i do it for the tacos.
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