Would You Consider a Caffeine Analogue that is 100x More Potent Than Caffeine Safe?

[kerplunk]

1,3-N-Dipropyl-7-Propargylxanthine found in two new products from a company that we wont name, but we will call XPV Sports.



The most potent caffeine analogue was 1,3-di-n-propyl-7-propargylxanthine,
which was about 100-fold more potent than caffeine at both A1 and A2
receptors.

http://www.erowid.org/chemicals/caff...emistry1.shtml
http://www.ncbi.nlm.nih.gov/pubmed/3806581



Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
Daly JW, Padgett WL, Shamim MT.

A variety of analogues of caffeine and theophylline in which the 1-,3-, and 7-methyl substituents have been replaced with n-propyl, allyl, propargyl, and isobutyl and, in a few cases, with chloroethyl, hydroxyethyl, or benzyl were assessed for potency and selectivity as antagonists at A1- and A2-adenosine receptors in brain tissue. Caffeine and theophylline are nonselective for these receptors. Nearly all of the 22 analogues of caffeine are more potent than caffeine itself at adenosine receptors. Replacement of the 1-methyl moiety with n-propyl, allyl, or propargyl substituent has little effect on potency at the A1 receptor while enhancing potency about 7- to 10-fold at the A2 receptor. 3,7-Di-methyl-1-propylxanthine is only slightly (1.4-fold) more potent than caffeine at the A1 receptor while being 10-fold more potent at the A2 receptor. 1,3-Di-n-propyl-7-methylxanthine is also selective for the A2 receptor, being 8-fold more potent than caffeine at the A1 receptor and 40-fold more potent at the A2 receptor. A number of other caffeine analogues including 3,7-dimethyl-1-n-propylxanthine, 7-allyl-1,3-dimethylxanthine, and 1,3-dimethyl-7-propargylxanthine are also somewhat selective for the A2 receptor. The most potent caffeine analogue was 1,3-di-n-propyl-7-propargylxanthine, which was about 100-fold more potent than caffeine at both A1 and A2 receptors. The 10 theophylline analogues were relatively nonselective except for the 1-ethyl analogue and the 1,3-diallyl analogue, which were selective for the A2 receptor, and the 1,3-di-n-propyl, 1,3-diisobutyl, and 1,3-dibenzyl analogues, which were somewhat selective for the A1 receptor. 1,3-Di-n-propylxanthine was 20-fold more potent than theophylline at the A1 receptor and 5-fold more potent at the A2 receptor.

[Team Punishment]

In b4 VPX reps.

[kerplunk]

Originally Posted by Team Punishment

In b4 VPX reps.

No such company as XPV, i just made it up... what you talkin about?

[adrenergic]

Aware, but what is the dosing?


If it is 100x more powerful but they only use 2mg, I don't see a problem. However the list of stims in that supp is crazy.

[kerplunk]

Originally Posted by adrenergic

Aware, but what is the dosing?


If it is 100x more powerful but they only use 2mg, I don't see a problem. However the list of stims in that supp is crazy.

Oh come on, you expect to know doses?!?!?! you know thats top secret info!!!! Youre not allowed to know dosages of stimulants man... its all in the secret of success.

[adrenergic]

Originally Posted by kerplunk

Oh come on, you expect to know doses?!?!?! you know thats top secret info!!!! Youre not allowed to know dosages of stimulants man... its all in the secret of success.

Lol shoulda known it was proprietary before I even asked.


Also, guggulsterones ****ing suck.

[kerplunk]

strong lack of care

[kerplunk]

I think this is relavent nowadays

[xxtotuxx]

Originally Posted by Team Punishment

In b4 VPX reps.

This..

[WIULifter]

id be slightly worried.

[un19]

Originally Posted by adrenergic

However the list of stims in that supp is crazy.

that's a problem with fat burners these days....some of them are like legal crack. missing the days of eca simple easy and very effective