Primordial Performance's - Dermacrine Write-Up

[Trauma1]

What is Dermacrine?

Dermacrine is a topical cream that boosts male hormone levels. This enhances performance, reduces body fat, and increases lean muscle. At 4 pumps Dermacrine will last 27 applications, at 5 pumps it will last 23 applications.

Dermacrine is a complete hormonal optimization formula which contains balanced levels of active bio-identical hormones and natural anti-estrogens. These delicate active ingredients are delivered by Primordial Performance's advanced OHV topical delivery system, and carried directly to the blood stream. This unique delivery system enhances the uptake and efficiency of the active ingredients for immediate physiological benefits.

Pushing past plateaus and encouraging new muscular growth requires high levels of anabolic & androgenic hormone activity. By supplying the body with high amounts of pro-hormones (aka, hormone precursors), Dermacrine dramatically increases the body's anabolic and androgenic capacity. This "hormonal edge" becomes noticeable within hours of application, fueling the body with the high-octane, adrenaline-pumping, rock-crushing power that raises performance to a new level.


What are anabolic & androgenic hormones?

Anabolic means stimulation of growth, as in muscle growth. Androgenic means stimulation of male characteristics such as libido, strength, and aggression. Testosterone is a perfect example of a hormone that possesses anabolic & androgenic properties.

Unknown to most, is the "other" naturally occurring hormones that have strong anabolic & androgenic properties - just like Testosterone. For instance, androstenediol and androstenedione both have anabolic & androgenic activity that supports muscle growth, fat loss, and muscular strength. Dermacrine not only boosts testosterone, but it also boosts these other male hormones. (1,2)


What are the ingredients and how do they work?

The primary hormone in Dermacrine is DHEA (dehydroepiandrosterone) - the precursor to all anabolic/andrognic hormones in the body. (1)

Although DHEA has been available for years, and is found in many other hormonal supplements, Dermacrine offers a distinct advantage that makes it up to 20x more effective than oral based products. You see, when DHEA is delivered topically and absorbed through the skin, it is forced to convert to more anabolic/androgenic hormones. (3-11) This is because the skin is highly concentrated with steroid-converting (steroidogenic) enzymes that catalyze the conversion of DHEA to more powerful hormones, such as androstenediol, androstenedione and testosterone. (4-11) This is where Dermacrine gets it's anabolic & androgenic horsepower - for increasing strength and lean muscle beyond your natural limit.

The DHEA is also converted to more powerful fat burning hormones such as 7-oxo-DHEA and 7-beta-DHEA. (5) These are powerful thermogenic hormones that increase the rate of fat loss, helping you shed fat as you gain muscle. (12-17) Oral DHEA products do not provide these same effects, since the digestive track lacks the same steroidogenic enzyme activity as the skin. (4)

The second hormone in Dermacrine is pregnenolone. This hormone was added in a precise ratio with the DHEA to balance and control conversion to DHT (dihydrotestosterone), which may cause hair loss in men prone to androgenic alopecia. (24) Those sensitive to DHT who are concerned with hair-loss need not worry; Dermacrine won't cost you the hair-line! Pregnenolone is also a powerful neurosteroid, which can enhance cognitive focus and memory. (21-23)

Since certain anabolic & androgenic hormones can convert to estrogen, Dermacrine was fortified with an anti-estrogen complex which consists of resveratrol, 7,8 benzoflavone and chrysin. These are natural plant based compounds that block estrogenic effects such as gyno and fat storage. (25-33) Resveratrol, 7,8 benzoflavone and chrysin have also been proven to have potent fertility stimulating properties, which can help promote increased sexual desire, erectile function and stamina. (25-33)


What sort of results should I notice with Dermacrine?

Within the first couple days the following results should become noticeable -

Increased motivational energy
Improved cognitive focus & drive (20,23,37)
Improved libido & sexual performance
Within 2-3 weeks users start to notice -

Enhanced strength during training
Increased stamina in the gym & bedroom
Faster recovery time (35,38-40)
Aggressive increase in appetite
Better sleep quality
Improvements in generally well-being (34,36,37)
Even without changes in diet or exercise Dermacrine will cause an improvement in body composition of a 2-3 lb loss in fat with a 2-3 lb gain in lean muscle within a 4-6 week period. This shift in body composition is most noticeable when proper "pre" and "post" measurements are taken. As with any muscle building product, best results are obtained when combined with high protein intake, heavy weight training and sufficient rest.

Also, see our collection of in-house hormone analyses from three men of different ages -


22 year old tester
31 year old tester
44 year old tester



How long can I use Dermacrine? Do I have to take time off?

Since Dermacrine supplies the body with an outside source of hormones and causes such a significant boost in hormone levels, it can eventually suppress the body's natural hormone production. Therefore, it is recommended that Dermacrine be cycled to avoid inhibition.*

We recommend using Dermacrine for 4 weeks at a time, with at least 4 weeks off between each cycle. 6-8 week cycles with Dermacrine are safe, however if you choose to use Dermacrine for longer than 4 weeks we recommend you consider post cycle therapy (PCT) after the cycle to ensure quick and full recovery of natural testosterone production.

For more information about PCT, please visit our forum.

* Men on long-term hormone or testosterone replacement therapy (HRT/TRT) may use Dermacrine indefinitely with their hormonal regimen since shutdown of natural testosterone production is generally acceptable.


Are there any side effects?

Aside from the above mentioned suppression of your body's hormone production, using Dermacrine within the recommend dose is safe for men, granted there are no serious pre-existing medical conditions. The only side-effects to consider could possibly be irritability or semi-anxiety which is generally avoidable if the user is participating in vigorous physical activity on a daily basis.


Why should I choose Dermacrine over other pro-hormones?

As explained earlier, Dermacrine is more effective than oral DHEA supplements because it delivers DHEA through the skin. Delivering DHEA through the skin forces it to convert to more powerful anabolic & androgenic hormones, because of the enzyme activity in the skin.

Unlike other orally active pro-hormones or pro-steroids, Dermacrine does not stress the liver, prostate or cholesterol levels. Dermacrine will also not cause the typical side effects of lethargy or appetite suppression because of toxic effects. The hormones in Dermacrine are non-toxic and naturally occurring in the human body.








Buy this product at the bb.com store, here!: Primordial Performance - Dermacrine

[Trauma1]

References -

1. Sex Steroid Metabolism in Human Peripheral Blood Mononuclear Cells Changes with Aging
The Journal of Clinical Endocrinology & Metabolism 90(11):6283-6289 (2005)

2. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages.
Schmidt M, et al.
J Endocrinol. 2000 Feb;164(2):161-9.

3. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat
C Labrie, et al.
Sep 1996; 150: S107 - S118.

4. Effects of transdermal application of DHEA to men on the levels of steroids, gonadotropins and lipids.
SULCOVÁ J, et al.
Physiol Res 49: 685-693, 2000.

5. Transformation in vitro of [4-14C ] dehydroepiandrosterone into 7-oxygenated derivatives by the normal human male and female skin tissue.
Faredin, I., et al.
J. Invest. Dermatol. 52:357. 1969

6. The metabolism of [4-14C] 5 androstene-3P, 17P-diol by normal human skin in vitro.
Faredin, et al.
Acta Med. Acad. Sci. Hung. 32:139. 1975.

7. Sebocytes are the key regulators of androgen homeostasis in human skin.
M Fritsch, et al.
J Invest Dermatol, May 1, 2001; 116(5): 793-800.

8. Transformation and conjugation of dehydroepiandrosterone by human skin.
Berliner, D. L., et al.
J. Clin. Endocrinol. 27:1214. 1967.

9. The formation of water soluble steroids by human skin.
Berliner, D. L., et al.
J. Invest. Dermatol. 50:220. 1968

10. The in vitro metabolism of dehydroepiandrosterone in human skin.
I Faredin, et al.
Acta Med Acad Sci Hung, Jan 1967; 23(2): 169-79.

11. The metabolism of [4-14C] dehydroepiandrosterone by human skin in vitro. I. Transformation in vitro of [4-14C] dehydroepiandrosterone into Androst-4-ene-3,17-dione, testosterone and androsterone by normal human male and female skin slices.
I Faredin, et al.
Acta Med Acad Sci Hung, Jan 1970; 27(1): 95-102.

12. Ergosteroids: Induction of Thermogenic Enzymes in Liver of Rats Treated with Steroids Derived from Dehydroepiandrosterone.
H Lardy, et al.
PNAS, Jul 1995; 92: 6617

13. Ergosteroids VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: A liquid chromatographic mass spectrometric study.
Marwah, A., et al.
J. Chromatog. (2002). B 767, 285-299.

14. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.
LARDY H, et al.
Proc Natl Acad Sci USA 92: 6617-6619, 1995.

15. A randomized, double blind, placebo controlled study of 3 - acetyl - 7 - oxo - dehydroepiandrosterone in healthy overweight adults.
Kalman, D., et al.
(2000). Curr. Ther. Res. 61, 435-442.

16. The effect of 7 - keto Naturalean on weight loss: A randomized, double blind placebo controlled trial. Zenk, J., et al.
(2002). Curr. Ther. Res. 63, 263-272.

17. How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influence thyroid function.
R Hampl, et al.
Physiol Res, Jan 2006; 55(1): 49-54.

18. DHEA treatment for HIVþ patients: Effects on mood, androgenic and anabolic parameters.
Rabkin, J., et al.
Psychoneuro endocrinology. R. 25, 53-68. 2000

19. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men.
Khorram O, et al.
J Gerontol 1997; 52A:M1- M7.

20. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women.
Casson PR, et al.
Am J Obstet Gynecol. 169:1536-1539. 1993

21. Novel brain function: biosynthesis and actions of neurosteroids in neurons.
K Tsutsui, et al.
Neurosci Res, Apr 2000; 36(4): 261-73.

22. Individual differences in cognitive aging: implication of pregnenolone sulfate.
W Mayo, et a.
Prog Neurobiol, September 1, 2003; 71(1): 43-8.

23. Memory-Enhancing Effects in Male Mice of Pregnenolone and Steroids Metabolically Derived from it.
JF Flood, et a.
PNAS, Mar 1992; 89: 1567.

24. Steroid 5alpha-reductase inhibitors.
E Flores, et al.
Mini Rev Med Chem, May 1, 2003; 3(3): 225-37

25. Die Bedeutung der Passionsblume in der Heilkunde.
Lutomski J et al.
Pharmazie in unserer Zeit 1981;10:45-49.

26. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies.
Tyler VE et al.
Pharmaceutical Products Press, New York, 1993.

27. Drug/substance reversal effects of a novel trisubstituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. -a brief perspective
KAMALDEEP DHAWAN et al.
Addiction Biology (December 2003) 8, 379 - 386

28. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
K Dhawan and et al.
Life Sci, Nov 2002; 71(26): 3059-69.

29. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
Kao YC, et al.
Environ Health Perspect 1998;106:85-92

30. Inhibition of human estrogen synthetase (aromatase) by flavones
JT Kellis, Jr et al.
Science, Sep 1984; 225: 1032 - 1034.

31. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells
Yun Wang, et al.
Toxicol. Sci., Jul 2006; 92: 71 - 77.

32. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. Em?*lia Juan, et al.
J. Nutr., Apr 2005; 135: 757 - 760

33. trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.
S Shin, et al.
Arch Pharm Res, Jan 2008; 31(1): 83-7.

34. An open- label dose- escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease.
Dyner TS, et al
J Acquir Immune Deficiency Syndrom 1993;6:459- 465.

35. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. Morales AJ, et al.
J Clin Endocrinol Me tab 1994;78:1360- 1367.

36. DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells.
PS Liu et a.
J Biomed Sci, Mar 2004; 11(2): 200-5.

37. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range.
Friess E, et al.
Am J Physiol 1995;268:E107-E113.

38. Anticortisols: Their Potential Usefulness.
Baulieu, et al.,
Las Vegas , NV : Conference on Cortisol and Anti-Cortisols, 1997

39. Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing.
CC Head, et al.
Brain Behav Immun, Nov 2006; 20(6): 590-6.

40. Androstenetriol improves survival in a rodent model of traumatic shock.
AC Marcu, et al.
Resuscitation, December 1, 2006; 71(3): 379-86.

[Primordial Perf]

subbed for questions.

-Eric

[Trauma1]

I'd also like to hear some feedback from those guys that have used dermacrine.

[MRB123]

rockin the old school bottle on the top. LOL

[kknecht1]

Would it be better to stack Havoc with Dermacrine or 1-T? Also what are some other (PH/DS) products that stack well with Dermacrine and 1-T?

[Primordial Perf]

Would it be better to stack Havoc with Dermacrine or 1-T? Also what are some other (PH/DS) products that stack well with Dermacrine and 1-T?

You can stack Dermacrine and 1-T with just about anything depending on your goals.

But you have to be careful with 1-T TREN. It is a beast, and it doesn't always play nice with others? (eg, progestin based or aromatizing pro-hormones would be a bad idea)


-Eric

[Trauma1]

rockin the old school bottle on the top. LOL

That's how we roll!

[MRB123]

That's how we roll!

yes yes it is

[Peter LeDrew]

I'd also like to hear some feedback from those guys that have used dermacrine.

Me 2.

[WIULifter]

VaughnTrue, i believe it was him, said that Demacrine and Act X was one of his favorite stacks. Anyone else pair these two up?

[kknecht1]

VaughnTrue, i believe it was him, said that Demacrine and Act X was one of his favorite stacks. Anyone else pair these two up?

I am planing to stack dermacrine with X-factor, an AI, and test booster (Maybe mass fx, or T-force). I was going to use this for a cut, but I am staying pretty lean (Two more pounds I will hit 200lb). So I am thinking about using it soon to continue my bulk. I will log it if you guys would be interested.

[WIULifter]

I am planing to stack dermacrine with X-factor, an AI, and test booster (Maybe mass fx, or T-force). I was going to use this for a cut, but I am staying pretty lean (Two more pounds I will hit 200lb). So I am thinking about using it soon to continue my bulk. I will log it if you guys would be interested.

sure man, i would follow

[Peter LeDrew]

VaughnTrue, i believe it was him, said that Demacrine and Act X was one of his favorite stacks. Anyone else pair these two up?

Well that is interesting.

sure man, i would follow

Make that two of us.

[Adjusting]

I am planing to stack dermacrine with X-factor, an AI, and test booster (Maybe mass fx, or T-force). I was going to use this for a cut, but I am staying pretty lean (Two more pounds I will hit 200lb). So I am thinking about using it soon to continue my bulk. I will log it if you guys would be interested.

I'd follow that. Do it up!

[IKnowWhoYouAre]

it has DHEA so it IS a PH right?

[Adjusting]

it has DHEA so it IS a PH right?

You bet.

[factotum]

What evidence is there to suggest that 7,8-benzoflavone, resveratrol, or chrysin will have viable bioavailability via a percutaneous drug delivery system? Granted they have a molecular weight that should not impede penetration but that alone will not suffice.
But what about lipophilicity/hydrophobicity and polarity? These are equally as important factors for cutaneous permeation. In addition, if you could disclose the partition coefficient for the aforementioned ingredients it would be appreciated.

[Primordial Perf]

What evidence is there to suggest that 7,8-benzoflavone, resveratrol, or chrysin will have viable bioavailability via a percutaneous drug delivery system? Granted they have a molecular weight that should not impede penetration but that alone will not suffice.
But what about lipophilicity/hydrophobicity and polarity? These are equally as important factors for cutaneous permeation. In addition, if you could disclose the partition coefficient for the aforementioned ingredients it would be appreciated.

No evidence except for what we observe.

It makes more sense in the real world to just apply the formula and observe plasma T, LH & FSH levels and anecdotal reports. The ingredients are readily dissolved in our co-solvent phase so solubility is certainly not an issue with our TD.

-Eric

[MRB123]

I have a feeling we will be seeing some logs on this soon

[Peter LeDrew]

I have a feeling we will be seeing some logs on this soon

That would be great!

[Trauma1]

I have a feeling we will be seeing some logs on this soon

Indeed!

[Rucker12]

I have a feeling we will be seeing some logs on this soon

When?

[MRB123]

When?

sometime next week!

[Adjusting]

Sooner the better MRB

[MRB123]

Do we have the giveaway going for this yet??

[_Smitty_]

logs are comin' up...

Primordial Performance Dermacrine log! (bloodsimple1234)

Free Weight Friedel's Primordial Performance Dermacrine Log

GAK Presents Primordial Performance Dermacrine Done Right (getbustered)

[Peter LeDrew]

logs are comin' up...

Primordial Performance Dermacrine log! (bloodsimple1234)

Free Weight Friedel's Primordial Performance Dermacrine Log

GAK Presents Primordial Performance Dermacrine Done Right (getbustered)

Damn, Deja vu or something!?!

[_Smitty_]

Damn, Deja vu or something!?!

[Adjusting]

>>>>>>>>>>>>>>>>>> Dermacrine Final review and Thoughts! <<<<<<<<<<<<<<<<<



~~~~> as far as muscle building, it was pretty good.I gained a solid 3 lbs in three weeks,about what I set out for.



~~~~~~> what I didn't set out for was everything else! the nice effects it has had on my skin are impressive! my skin is much smoother,radiant and overall tighter! It is hard to explain beyond that! no issues beforehand just very impressed at how much better it looks!




~~~~~~~~> Libido..... very,very good the 1st couple of weeks.It increased a lot the 1st couple of weeks and very well at that! the last week was unreal! let's just say I was waking up in the am with a little surprise that didn't go away for a little bit.


~~~~~~~~~~~~~~~> drive was very,very good too.I train very late at night with no stims so all I was looking for was just a little extra drive and focus.I got exactly what I wanted here! happy about that!


~~~~~~~~~~~~~~~~~~~~~~>Sleep,this is by far the best aspect of this product!
the sleep I got from it was deep and I had very,very VIVID dreams.This too,was an area I didn't have a lot of trouble in however It was just so improved it was unreal!



any other questions or comments please feel free to pm me with them!

I really enjoyed this product and would not rule it out in the future,DEF will take it later on.This worked well for me,I can't imagine the benefits to someone older then me,I think it would work A TON better for someone at least several years older if not more.





EIther way if you are looking at this product,def give it a shot.One way or another you will certainly not be dissapointed!





* thanks to all the reps and everyone else who took some time out to read and comment! *

....