Quote:
Originally Posted by Mumof2
Thanks for your reply. I just worry about a creatine buildup. Had a friend that had kidney failure after using creatine. He claims he used it correctly, but maybe he didnt hydrate enough, I don't know. Anyway, have been told different things - do 4 weeks, the off for 1-3 then back on, or 3 months on frew weeks off....gets all very confusing!
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Creapure has been studied extensively and no toxic effects were determined by any of these tests. All of the studies were carried out on Creapure in accordance with internationally accepted guidelines and standards (FDA and EU) under GLP (Good Laboratory Practice) conditions.
Furthermore, numerous animal and human trials were commissioned to test the safety of Creapure as a supplement. In addition to the classic toxicological tests, Creapure was investigated in more than 50 clinical trials. People of all ages tested Creapure in sports and non-sports applications over a period of more than 21 months without experiencing any side-effects.
Because other creatine manufacturers use different manufacturing processes, and therefore have different purity profiles, only Creapure has this proven safety profile.
Creatine ? the focus of more than 300 scientific studies ? is now one of the most extensively researched dietary supplements in the field of sports nutrition. Creatine supplementation has become a common practice among professional, elite, collegiate, and amateur athletes for enhancing performance.
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In recent years, numerous papers have been published in professional journals and elsewhere evaluating the long-term use and clinical safety of oral creatine monohydrate supplementation using Creapure.
The main focus was to evaluate if long-term Creapure supplementation (average of 5 grams/day) might increase the incidence of musculoskeletal injury, heat-related disorders (e.g., dehydration and cramping), and renal stress.
Clinical assessments included analyzing a comprehensive panel of serum and whole blood markers (electrolytes, muscle and liver enzymes, substrates, lipid profiles, red and white blood cells, etc.), renal function tests determined by creatinine clearance, monitoring of injuries treated by the medical/athletic training staff, as well as the collection of medical safety and fatigue/weakness data.
The results of these safety studies on the long-term use of Creapure have consistently shown that, in comparison to athletes who did not take creatine, those who took creatine did not experience a greater incidence of injuries, heat-related disorders (dehydration), cramping, musculoskeletal injuries, or gastrointestinal disturbances. Additionally, athletes who took creatine over a long period did not have significantly higher muscle and liver enzymes, altered electrolytes, or increased renal stress determined by creatine clearance.
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