Novedex by Gaspari Nutrition - will cause a positive Boldenone result

[Laduem88]

i found this on another forum...thought it was interesting


It turns out that one of the metabolites of ATD (an oral aromatase inhibitor marketed as Novedex XT by Gaspari Nutrition) will cause a positive result on a doping analysis?it will appear that the athlete has taken boldenone (Equipoise). It?s not ?spiked? or adulterated, but the actual compound happens to be metabolized into boldenone (Equipoise) and a boldenone metabolite as well. Again, this does not mean that Novadex XT is contaminated or adulterated, but simply that it converts to trace amounts of a banned substance in the body.

Another study on Novedex XT (not the abstract I printed below) shows that it is a good fat loss agent, but indicates (to me) that it is highly unlikely that it converts to enough Boldenone to cause an anabolic effect.

This could be a possible explanation for yesterday?s Major League Baseball positives?

Rapid Commun Mass Spectrom. 2009 Jan 30;23(2):207-218.Click here to read Links
Metabolism of androsta-1,4,6-triene-3,17-dione and detection by gas chromatography/mass spectrometry in doping control.
Parr MK, Fu?h?ller G, Schl?rer N, Opfermann G, Piper T, Rodchenkov G, Sch?nzer W.

Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.

The urinary metabolism of the irreversible aromatase inhibitor androsta-1,4,6-triene-3,17-dione was investigated. It is mainly excreted unchanged and as its 17beta-hydroxy analogue. For confirmation, 17beta-hydroxyandrosta-1,4,6-trien-3-one was synthesized and characterized by nuclear magnetic resonance (NMR) in addition to the parent compound. In addition, several reduced metabolites were detected in the post-administration urines, namely 17beta-hydroxyandrosta-1,4-dien-3-one (boldenone), 17beta-hydroxy-5beta-androst-1-en-3-one (boldenone metabolite), 17beta-hydroxyandrosta-4,6-dien-3-one, and androsta-4,6-diene-3,17-dione. The identification was performed by comparison of the metabolites with reference material utilizing gas chromatography/mass spectrometry (GC/MS) of the underivatized compounds and GC/MS and GC/tandem mass spectrometry (MS/MS) of their trimethylsilyl (TMS) derivatives. Alterations in the steroid profile were also observed, most obviously in the androsterone/testosterone ratio. Even if not explicitly listed, androsta-1,4,6-triene-3,17-dione is classified as a prohibited substance in sports by the World Anti-Doping Agency (WADA) due to its aromatase-inhibiting properties. In 2006 three samples from human routine sports doping control tested positive for metabolites of androsta-1,4,6-triene-3,17-dione. The samples were initially found suspicious for the boldenone metabolite 17beta-hydroxy-5beta-androst-1-en-3-one. Since metabolites of androst-4-ene-3,6,17-trione were also present in the urine samples, it is presumed that these findings were due to the administration of a product like ?Novedex Xtreme?, which could be easily obtained from the sport supplement market. Copyright (c) 2008 John Wiley & Sons, Ltd.

[G.K.]

PA just posted this the other day.

Interesting nonetheless...

[steeltown412]

the stuff works imo...

[Laduem88]

PA just posted this the other day.

Interesting nonetheless...

my bad..have been out of town for the past 5 days

[starterz]

intresting. This will be my first test booster i will be trying

[force_]

Damn, thats a new one.

Ive used it, liked it but I would love to hear from some Gaspari reps on this one?

F.

[Derly]

Antonio (Big Foot) Silva proffesional HW mma fighter took this, and got banned from being liscensed in the United States for a year. That was a while ago too.

[starterz]

bump....anyone

[deserusan]

Damn, thats a new one.

Ive used it, liked it but I would love to hear from some Gaspari reps on this one?

F.

ATD is structurally similar to boldione and differs by only by a conjugated double bond at the C6 position. This is not something new per se, as we have openly told people not to take this product if they are being tested by a sanctioned organization. Furthermore, aromatase inhibitors are banned by WADA, the IOC, etc which govern the doping policies of all professional sports organizations.

While ATD isn't listed specifically on their banned list, it is by default included because it's an AI. I would also like to further point out that athletes are also required to run their supplements by their trainers for approval and the fighter mentioned above lied on a pre-fight questionnaire and his supplement use.

I guess the thing for all of us to understand here is that supplement warnings should be taken seriously. While some can be misconstrued as fluff, we have always been clear that ours should be taken seriously. I hope that helps.

-D

[force_]

Thanks Des, as always you are a great source of information!

F.

[TENACIOUS]

I was dosing XT at 6 pills a day plus taking Diesel products on top of that for 54 days. At day 54 I paid for my own Drug test and consulted with the Doctor and I was completely clean. Besides testing NEG for everything my T.E. ratio was 1.17 and according to the Dr. which he described as normal.

just my two dimes worth.

[chachi1984]

it does say that on the label. it you are going to be tested then maybe you should check into what you are taking even if its a legal supplement

[Big Poppa S]

Recently a Canadian powerlifter (also Nationally ranked and Natual Pro bodybuilder) tested positive for Boldenone metabolites at the same time he was taking Novedex XT. Guess he didn't read the warning labels or maybe it's just his excuse to cover up what he was really taking? Who knows?

[sl4vik]

I was dosing XT at 6 pills a day plus taking Diesel products on top of that for 54 days. At day 54 I paid for my own Drug test and consulted with the Doctor and I was completely clean. Besides testing NEG for everything my T.E. ratio was 1.17 and according to the Dr. which he described as normal.

just my two dimes worth.

6 pills day? You realize the max is 2 right?

[Illadelphia]

6 pills day? You realize the max is 2 right?

Bros don't follow rules brah

[Come at me bro]

I run it for 2 months at 2 pills a day, gonna grab some more and run at the max or more when I find a sale

Good ****

[|ceman]

6 pills day? You realize the max is 2 right?

2-4 at a top range. That poster is a big dude, so the top range would be ok, provided he responds well; but 6 is a little nuts, IMO.

[TENACIOUS]

6 pills day? You realize the max is 2 right?

Yea dude I know exactly what I am doing. 45 years old and have been around the block a few times. 2 is a guide line. Anyone who has ever experimented with supps know that the labels and the recommended dosage is really a suggestion. I spoke to a rep at GAS and because of my size and experience 6 was OK. And I get blood test routinely.

the Canadian guy either lied to cover his ass or there is a problem with the whole line. I believe he is a liar.

Unless you take XT off the shelf and have it tested or run a test with controlled groups I do not believe any of the accusations.

[TENACIOUS]

2-4 at a top range. That poster is a big dude, so the top range would be ok, provided he responds well; but 6 is a little nuts, IMO.

I weigh in at 300lbs with 22.5 BF% and yes I am a little nuts. Again I had blood test done and 6 was just perfect for me. Free test before XT was 71 and after XT they were at 200.

[|ceman]

I weigh in at 300lbs with 22.5 BF% and yes I am a little nuts. Again I had blood test done and 6 was just perfect for me. Free test before XT was 71 and after XT they were at 200.

Just be careful - you don't want to inhibit too much estrogen.


a reasonable balance is needed.

[IBE Labs]

well say goodbye to ATD now because the FDA will now be going after it because now the footplayers get to take real EQ and when test positive for boldenone and they just blame ATD. was this test just done in 2009?

[deserusan]

well say goodbye to ATD now because the FDA will now be going after it because now the footplayers get to take real EQ and when test positive for boldenone and they just blame ATD. was this test just done in 2009?

Yeah...since I first posted in this thread a year ago ATD is now listed as a banned substance by WADA. Before it was just a non-specific ban of aromatase inhibitors and now it's specific. The writing has been on the wall with anything steroidal let alone AI's like ATD that they won't be around much longer.

[TENACIOUS]

just be careful - you don't want to inhibit too much estrogen.


A reasonable balance is needed.

yes sir you are correct. I am very careful.

[gndrkavala]

Since i used this product for 30 days and there is a good chance i may go through doping-control, does anyone know how long does it take to be undetectable?

[sweew]

Since i used this product for 30 days and there is a good chance i may go through doping-control, does anyone know how long does it take to be undetectable?

a Gaspari rep told me 30 days. But I don´t know for sure. Would also like to know?

[Zachattack43]

Since i used this product for 30 days and there is a good chance i may go through doping-control, does anyone know how long does it take to be undetectable?

Nope sorry man, thus why have the warning on the label for those getting drug tested for competitions, etc.