Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise
Tim Ziegenfuss email, Jamie Landis and Jennifer Hofheins
The Center for Applied Health Science Research, Division of Sports Nutrition and Exercise Science, Fairlawn, OH 44333, USA
Background
Many of the positive adaptations resulting from resistance exercise training (i.e., increased muscle mass and strength, decreased fat mass) are thought to be mediated, in part, by exercise-induced increases in growth hormone (GH). One ingredient that has shown clinical promise in elevating GH is the acetylcholine precursor alpha-glycerylphosphorylcholine (A-GPC). The purpose of this study was to examine the effects of a supplement containing primarily A-GPC on serum GH levels, explosive performance, and post-exercise substrate oxidation.
Methods
Using a randomized, placebo-controlled, crossover design, seven men (mean ? SD age, height, weight, body fat: 30.1 ? 7.3 y, 179.2 ? 7.4 cm, 87.3 ? 11.6 kg, 18.1 ? 5.9%) with at least two years of resistance training experience ingested 600 mg A-GPC (as AlphaSize?) or a placebo 90-minutes prior to completing 6 sets ? 10 repetitions of Smith Machine squats at 70% of their pre-determined 1-repetition maximum. At 30-minutes post-exercise, resting metabolic rate (RMR) and respiratory exchange ratio (RER) were measured with indirect calorimetry to assess post-exercise caloric expenditure and carbohydrate and fat oxidation, respectively. Immediately following RMR and RER measurements, subjects performed three sets of bench press throws at 50% of their pre-determined 1-repetition maximum to assess peak force, peak power, and rate of force development. All trials were performed after an overnight fast, a 48-hour abstention from intense exercise, and during the same time of day to minimize diurnal variation. Serum samples were obtained prior to exercise and again 0, 5, 15, 30, 60, 90 and 120 minutes post-exercise. Hormone concentrations were analyzed in duplicate by Quest Diagnostics? via immunoassay. Statistical evaluation of the data was accomplished using dependent t-tests (peak force, peak power, rate of force development) and repeated measures ANOVA (GH, RMR, RER). Differences were considered "significant" at P ≤ 0.05.
Results
Compared to baseline (pre) values, peak GH increased 44-fold during A-GPC (from 0.19 ? 0.06 to 8.4 ? 2.1 ng/mL) vs. 2.6-fold during placebo (from 1.9 ? 0.8 to 5.0 ? 4.8 ng/mL, P < 0.03) (Figure 1). Peak bench press force was 14% greater in A-GPC (933 ? 89 N) vs. placebo (818 ? 77 N, P < 0.02). Trends toward higher peak bench press power (P < 0.13) and lower post-exercise RER (P < 0.12) were noted in the A-GPC trial.
Conclusion
These data indicate that a single 600 mg dose of A-GPC (as AlphaSize?), when administered 90 minutes prior to resistance exercise, increases post-exercise serum GH and peak bench press force. In contrast, A-GPC had no statistically significant effect on peak power, rate of force development, RMR, or cardiovascular hemodynamics (i.e., heart rate and blood pressure). Future work should examine how resistance exercise + A-GPC affect the GH-IGF axis and their associated family of binding proteins.
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09-27-2008, 11:14 AM #1
Effects of Alpha-GPC on GH levels
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09-27-2008, 11:55 AM #2
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09-30-2008, 07:32 PM #3
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09-30-2008, 08:32 PM #4
That sounds pretty good, but Id guess on a 'fed' stomach it would be diminished.
These guys fasted overnight (12 hours? hard to say) and then worked out without eating anything and didn't eat after their workouts for 2 hours.
In a vacuum..it might work...but if it takes a dead empty stomach followed by a fasted workout with no proper pre / post nutrition and no meal till 2 hours later...forget it...give me food..Im not going without food 14 hours a day!!The Dark Knight...Rises.
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05-14-2009, 01:08 PM #5
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05-14-2009, 01:26 PM #6
From what I remember working with the commercially available alpha-gpc in bulk is that it was cut with around 50% "sugar" of some kind.
It's been a while."Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade
ThermoGum...Just Chew It!
---ACCELERATED gains * increased MASS = unstoppable FORCE--- Know your physics for maximum performance.
"Don't you know there ain't no Devil, there's just God when he's drunk" -Tom Waits
"The only question is...which is to be Master? That is all." - Lewis Carroll
"Who is John Galt?" - Ayn Rand
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05-14-2009, 02:36 PM #7
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05-14-2009, 02:43 PM #8
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05-14-2009, 03:45 PM #9
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05-17-2009, 11:58 PM #10
"from 0.19 ? 0.06 to 8.4 ? 2.1 ng/mL) vs. 2.6-fold during placebo (from 1.9 ? 0.8 to 5.0 ? 4.8 ng/mL)"
It's 44x vs 2.6x because the supplemented group had much lower (.19 vs 1.9) GH before workout. Gotta read the study. If they had had the same beginning GH levels it would have been a 4.4x increase. At the same time, you have to wonder whether the supplemented group reached higher levels DUE to their beginning low levels. We know that drastically reducing protein intake skyrockets GH levels, I'm just guessing and pulling this out of my ass, but could extremely low GH levels be easier to increase?
just sayin'.
oh, and no one trains fasted. studies done on fasted subjects are fun and all, but they are almost NEVER applicable. which really makes them useless.I want to touch the butt.
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05-18-2009, 05:09 AM #11
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05-19-2009, 06:25 PM #12
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05-20-2009, 06:58 AM #13"Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade
ThermoGum...Just Chew It!
---ACCELERATED gains * increased MASS = unstoppable FORCE--- Know your physics for maximum performance.
"Don't you know there ain't no Devil, there's just God when he's drunk" -Tom Waits
"The only question is...which is to be Master? That is all." - Lewis Carroll
"Who is John Galt?" - Ayn Rand
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05-20-2009, 07:57 AM #14
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05-20-2009, 08:06 AM #15
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05-20-2009, 09:07 AM #16
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05-20-2009, 09:19 AM #17
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05-20-2009, 10:36 AM #18
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05-20-2009, 10:41 AM #19
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05-20-2009, 10:47 AM #20
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05-20-2009, 11:01 AM #21
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05-20-2009, 11:06 AM #22
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05-20-2009, 11:19 AM #23
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05-20-2009, 11:31 AM #24
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05-20-2009, 11:33 AM #25
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05-20-2009, 11:38 AM #26
Pat- for a little while you had me sold.
I never heard about it. Had no clue what it was.
FYI- becuase you were suggesting it - it did peak my interest.
When I searched it out- I did laugh. Thanks for that.
the point is that becuase your name was there... it had stronger rep automatically.
You should consider doing somthing when the time comes .. and you have somthing worth doing it over... but don't wait too long... or you will lose some of the repuation you have as people forget and things change.
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05-20-2009, 11:38 AM #27
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05-20-2009, 11:52 AM #28
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05-20-2009, 12:20 PM #29
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05-20-2009, 12:27 PM #30"Blood, Sweat, and Tears doesn't mean crying while you struggle to put your tampon in." ~dsade
ThermoGum...Just Chew It!
---ACCELERATED gains * increased MASS = unstoppable FORCE--- Know your physics for maximum performance.
"Don't you know there ain't no Devil, there's just God when he's drunk" -Tom Waits
"The only question is...which is to be Master? That is all." - Lewis Carroll
"Who is John Galt?" - Ayn Rand
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