What is the difference between the two? I've searched and pretty much come up with nothing.
Which is better for the nutrient repartitioning effect? I'm using Anabolic Pump right now, but I am looking for a cheaper alternative but I can't figure out if ALA or r-ALA would be better. Thanks.
Thread: ALA vs. r-ALA
07-23-2008, 12:27 PM #1
ALA vs. r-ALA
07-23-2008, 12:31 PM #2
The beneficial properties of ALA, are derived from the R-ALA isomer. So, I would encourage buying R-ALA over racemic ALA.
I believe R-ALA to be more supported by the literature, for both being a healthy antioxidant as well as a insulin mimetic over Anabolic Pump. I would go with that over Anabolic Pump product.Exercise Physiologist/CI-CPT
07-23-2008, 12:32 PM #3
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ALA is typically a 50 : 50 combination of R-alpha-lipoic acid and S-alpha-lipoic acid. An R-ALA form (K, Na) would likely be better than racemic ALA. You probably won't get the same effects though.
This basically sums it up...
R-Lipoic Acid - Naturally occurring Lipoic Acid, the type the body makes and requires, contains the R form. This gives R-Lipoic Acid significantly more potency and efficacy, because the body "recognizes" R-Lipoic Acid and "knows" how to properly metabolize it (most key enzymes are structured to hold only the R-form).
S-Lipoic Acid is a by-product from chemical synthesis of racemic alpha Lipoic Acid and may inhibit the most essential properties of the R form, including interactions with proteins, enzymes and genes
Last edited by in10city; 07-23-2008 at 06:30 PM.It is the mark of an educated mind to be able to entertain a thought without accepting it.
07-23-2008, 12:43 PM #4
07-23-2008, 12:48 PM #5
07-23-2008, 05:24 PM #6
07-23-2008, 05:44 PM #7
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You might want to look into this thread:
My thoughts are just that; thoughts. Take anything I say with a grain of salt.
07-23-2008, 07:15 PM #8
07-27-2008, 12:52 AM #9
pure, unstabilized RLA has an extremely low GI absorption and bioavailability. unstablized RLA utizilized in most commercially available RLA products has an extremely poor disintegration/dissolution profile and tend to polymerize.
K-RALA is convereted to its more potent form R-dihydrolipoic acid, after reacting with and neutralizing an oxidant. R-dihydrolipoic acid is the reduced form of RLA, and is the only form that functions directly as an antioxidant. free RLA is rapidly taken up by cells and reduced to R-DHLA intracellularly. Although only R-DHLA functions directly as an antioxidant, RLA may have indirect antioxidant effects. a significant factor in aging is the decay of the mitochondria and as we age, the efficiency of the mitochondria diminishes, as well as their quantity per cell. K-RALA functions as a critical cofactor in several important enzymes related to energy metabolism. K-RALA is part of a potent antioxidant couple (with R-DHLA) that detoxifies the free radicals released during the energy-producing process. K-RALA has a significant effect on other cellular antioxidants such as vitamins C and E, as well as CoQ10 and glutathione.
K-RALA lowers the oxidative stress on the body. this stress is due to the tendency of oxidants to attack the body's molecular components. a high level of free radicals causes high oxidative stress. K-RALA has the ability to enter both lipid and water environments, unlike other antioxidants that are not capable of this dual function. K-RALA can protect the entire cell; the fatty cellular environments such as membranes, as well as the water-soluble cellular components that comprise the major part of the cell. K-RALA functions as a coenzyme by enhancing the utilization and disposal of glucose.
07-27-2008, 03:17 AM #10
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NA-RALA is currently the best form of stable R-Lipoic acid available.
PEA 750 mg caps: http://www.bodybuilding.com/store/uniq/peaultra.html
PEA Dosing: http://forum.bodybuilding.com/showpost.php?p=261217881&postcount=1379
07-27-2008, 03:24 AM #11
07-27-2008, 03:35 AM #12