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  1. #1
    STREET KING ILPump's Avatar
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    Forskolin raising testosterone levels??

    I have been doing some research on forskolin and have noticed that this ingredient is in a few natural test boosters, my question is does forskolin have any scientific backing that it actually helps to raise testosterone levels? I have seen a few people on this board including PA I believe mention that forskolin was shown to raise test. levels.. Any insight?
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  2. #2
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    Bump... anyone with any insight??
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    i cant find the abstract but there was a study done in obese men where it raised t-levels, but not significantly higher than a placebo. didnt find anything on it on pubmed.
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    Originally Posted by muscleman420 View Post
    i cant find the abstract but there was a study done in obese men where it raised t-levels, but not significantly higher than a placebo. didnt find anything on it on pubmed.
    http://www.nature.com/oby/journal/v1...y2005162a.html

    Funded by Sabinsa (patent on Forslean)
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  5. #5
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    So nothing more than an in house clinical on forskolin.... I'm going to keep searching but I thought I remember reading somewhere on here different people stating its been shown to raise T-levels and they were referencing things outside of that study just posted....
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    I just posted something similar, I read an article that states gain up to 8 lbs in 12 weeks and lose some body fat, might be worth a shot, BB.com sells it for 9.99 a bottle for a month's supply, can't hurt to try it for the price.
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  7. #7
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    Effects of forskolin are due to its upregulation of cAMP, which can stimulate hormone release. This is more likely to occur in pathways such as TRH and GHRH, precursors to common units known to cause lean mass gain.

    I didn't read the study on TEST, but I'm sure it does elevate to some extent.
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    T-BOL write-up:

    Forskolin is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Forskolin has a favorable effect on enhancing serum testosterone levels through it's potential influence on cAMP. Because LH exerts its effects on Leydig cells of the testicles (stimulating production of testosterone) through cAMP, an increase in testosterone levels using this compound is exhibited as well (43,44) In fact Forskolin is commonly used in studies to stimulate testosterone production from Leydig cells (45,46). Apart from this Forskolin exhibits a beneficial effect on reducing fat levels while increasing lean muscle mass. As a matter of fact, in a human study the Forskolin treated group increased mean free testosterone levels by up to 40% (49)


    [43] Valenti, S, Guido, R, Giusti, M, Giordano, G. (1995) In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production Endocrinology 136,5357-5362

    [44] Valenti, S, Fazzuoli, L, Giordano, G, Giusti, M. (2001) Changes in binding of iodomelatonin to membranes of Leydig cells and steroidogenesis after prolonged in vitro exposure to melatonin Int J Androl. 24,80-86

    [45] Serotonin secretion from rat Leydig cells.Tinajero JC, Fabbri A, Ciocca DR, Dufau ML.Section on Molecular Endocrinology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892.

    [46] Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Keeney DS, Mason JI. Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235-9051.

    [49] Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Michael P. Godard, Brad A. Johnson and Scott R. Richmond. Obesity Research (2005) 13, 1335–1343; doi: 10.1038/oby.2005.162
    Last edited by NO HYPE; 07-12-2008 at 08:15 AM.
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    Thank you NO HYPE this is what I was looking for.. When is that T-bol going to be available??? I'm VERY interested!!!
    Last edited by patriot1096; 07-12-2008 at 09:18 AM.
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    Thumbs up

    Originally Posted by patriot1096 View Post
    Thank you NO HYPE this is what I was looking for.. When is that T-bol going to be available??? I'm VERY interested!!!
    Check your PM's.

    http://www.thermolife.com/store/Scri...p?idproduct=18
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  11. #11
    STREET KING ILPump's Avatar
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    Originally Posted by NO HYPE View Post
    Yeah I was on your site looking at it and it's still in the pre-order status. Are you guys now shipping T-Bol??? I want to run a E-Bol and T-bol stack....
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    I'm trying the bulk powder now- third day.
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    Yes!!!

    i would say it does to a certain extent. I personally tried it from Nature's herbs and idk how great it was for building muscle but I can tell u that a little wind would get me all riled up. Sorry to be so descriptive but just to touch it to use the bathroom will get me crazy lol its so cheap its worth a try. Heard from friends that the effect was very similar, even if its just for that libido boost it will definately help. Just be sure to control urself lol it might be impossibe tho
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    Does this need to be cycled?
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    Originally Posted by Stevemeister86 View Post
    Does this need to be cycled?
    most herbs should be, allows u to reap full benefits, some ppl also change their herbs, keeps your body guessing. Your body is the smartest dumbest machine lol yes it does make sense
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  16. #16
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    Originally Posted by alex2992 View Post
    From what i can tell effects of forskolin are minimal on test. It effects c amp..whcih may result in very small test increase ...it should be mentioned it also results in increased aromatase....
    So what? If you increase your testicular activity some extra estrogen has to be expected alongside the extra testosterone(see DAA).
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    Originally Posted by RebuildMe View Post
    So what? If you increase your testicular activity some extra estrogen has to be expected alongside the extra testosterone(see DAA).
    so, anyone with pre-existing gyno, might like to be weary of it, that's what.
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  18. #18
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    Originally Posted by sliq3g View Post
    so, anyone with pre-existing gyno, might like to be weary of it, that's what.
    Anyone with pre-existing gyno should NOT mess with his hormones at all IMO.
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  19. #19
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    Originally Posted by alex2992 View Post
    It is used in some medical studies as an aromatase promoting agent....
    Not exactly. Forskolin incubation is relevant in certain cancer cell lines in which point mutations in the motif sequence impact whether or not it contains an effective cAMP response element. Cancer research showing forskolin's impact on the aromatase gene is not relevant in healthy adults.

    Further characterization of the molecular mechanism, including the binding protein for CLS and S1 motifs, may clarify the specific mechanism of CYP19 gene expression in adrenal tumors.
    http://joe.endocrinology-journals.or.../180/1/125.pdf

    FSK denotes forskolin, in normal osteoblasts (bone cells):
    The results of RT-PCR also suggest that promoter II, which responds to FSK, was not activated even in the presence of FSK in SV-HFO.
    http://www.eje.org/cgi/content/full/152/4/619
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    Originally Posted by PinchTheBear View Post
    Not exactly. Forskolin incubation is relevant in certain cancer cell lines in which point mutations in the motif sequence impact whether or not it contains an effective cAMP response element. Cancer research showing forskolin's impact on the aromatase gene is not relevant in healthy adults.

    Further characterization of the molecular mechanism, including the binding protein for CLS and S1 motifs, may clarify the specific mechanism of CYP19 gene expression in adrenal tumors.
    http://joe.endocrinology-journals.or.../180/1/125.pdf

    FSK denotes forskolin, in normal osteoblasts (bone cells):
    The results of RT-PCR also suggest that promoter II, which responds to FSK, was not activated even in the presence of FSK in SV-HFO.
    http://www.eje.org/cgi/content/full/152/4/619
    So basically its alleged aromatase-upregulating properties are just nonsense for someone using it orally as a supplement.
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  21. #21
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    Originally Posted by RebuildMe View Post
    So basically its alleged aromatase-upregulating properties are just nonsense for someone using it orally as a supplement.
    Exactly.
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  22. #22
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    Originally Posted by alex2992 View Post
    The same exporession has been observed in endometrial stromal cells in healthy females.
    Not to mention the role cAMP plays in increaszed aromatase....
    Re-read my post then read the full texts you're referencing (and post them here). I mean, due to the effects of cytokines and glucocorticoids on aromatase expression, you could argue that strength training "significantly" up-regulates aromatase... lol. It's really just splitting hairs and has no physiological relevance. We're usually dealing with obscene db-cAMP concentrations non-ceteris paribus.
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    Abstract
    We have previously demonstrated that the aromatase activity in human endometrial stromal cells is stimulated by progestin and enhanced by oestrogen. In this study, we have investigated the effect of forskolin (Fk), an agent that stimulates the hormone-sensitive adenylate cyclase in mammalian cells, on the intracellular cAMP content and aromatase activity in endometrial stromal cells in primary culture. Stromal cells were isolated from proliferative and secretory endometria and were individually cultured in nutrient medium or medium supplemented with medroxyprogesterone acetate (MPA), oestradiol (E2) and Fk, separately or in combination. The intracellular cAMP content of stromal cells was increased after incubation with Fk. Stromal cells treated with Fk alone or FK and MPA for 1-3 days sustained the elevated intracellular cAMP content but 90% of this nucleotide was released to the medium. Aromatase activity was either not affected or was increased up to 5-fold over the control by Fk alone. Forskolin exerted a synergistic effect upon aromatase activity in the presence of progestin or progestin and oestradiol. Sequential incubation of the stromal cells with MPA and then Fk indicated that the additional increase in aromatase activity caused by Fk occurred after 24 h of incubation. These results demonstrate that intracellular cAMP exerts a stimulatory effect on aromatase activity in progestin-conditioned stromal cells. We also investigated whether the endometrial aromatase activity changes in vivo during the reproductive cycle by measuring the activities in endometrial specimens obtained from women during their reproductive age.



    I don't see this relevant. Stimulatory effect... I need to find full text.
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    Originally Posted by PinchTheBear View Post
    Re-read my post then read the full texts you're referencing (and post them here). I mean, due to the effects of cytokines and glucocorticoids on aromatase expression, you could argue that strength training "significantly" up-regulates aromatase... lol. It's really just splitting hairs and has no physiological relevance. We're usually dealing with obscene db-cAMP concentrations non-ceteris paribus.
    bolded relates to this study. I don't find it relevant (but like I said, lacking full texts). The studies you posted seem to be closer to more of an "independance" of variables for the forskolin.
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    Originally Posted by wakingmalice View Post
    Abstract
    We have previously demonstrated that the aromatase activity in human endometrial stromal cells is stimulated by progestin and enhanced by oestrogen. In this study, we have investigated the effect of forskolin (Fk), an agent that stimulates the hormone-sensitive adenylate cyclase in mammalian cells, on the intracellular cAMP content and aromatase activity in endometrial stromal cells in primary culture. Stromal cells were isolated from proliferative and secretory endometria and were individually cultured in nutrient medium or medium supplemented with medroxyprogesterone acetate (MPA), oestradiol (E2) and Fk, separately or in combination. The intracellular cAMP content of stromal cells was increased after incubation with Fk. Stromal cells treated with Fk alone or FK and MPA for 1-3 days sustained the elevated intracellular cAMP content but 90% of this nucleotide was released to the medium. Aromatase activity was either not affected or was increased up to 5-fold over the control by Fk alone. Forskolin exerted a synergistic effect upon aromatase activity in the presence of progestin or progestin and oestradiol. Sequential incubation of the stromal cells with MPA and then Fk indicated that the additional increase in aromatase activity caused by Fk occurred after 24 h of incubation. These results demonstrate that intracellular cAMP exerts a stimulatory effect on aromatase activity in progestin-conditioned stromal cells. We also investigated whether the endometrial aromatase activity changes in vivo during the reproductive cycle by measuring the activities in endometrial specimens obtained from women during their reproductive age.
    Either no increase or an increase...yea...

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    A factor that significantly increases aromatase activity in osteoblasts, as did the combination of Dex and FSK in this study, would be beneficial, especially for the treatment of osteopenia and osteoporosis. Estrogen-replacement therapy (ERT) has been used to treat osteopenia and osteoporosis in postmenopausal women. However, ERT has various risks – for example uterine body cancer, thrombosis, and breast cancer –because ERT increases estrogen levels throughout the entire body. On the other hand, a drug that increases the expression of aromatase only in osteoblasts would increase the estrogen concentration only in bone tissue and would thus most likely not affect other tissues. The present study should form the basis for the development of such a tissue-specific ERT.
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    Originally Posted by wakingmalice View Post
    bolded relates to this study. I don't find it relevant (but like I said, lacking full texts). The studies you posted seem to be closer to more of an "independence" of variables for the forskolin.
    The variables are so extensive when you deal a ubiquitous second messenger, e.g.

    In contrast, the presence of 8-Br-cAMP for 2 days significantly decreased basal estradiol-17β output, as well as conversion of androstenedione to estradiol-17β; the conversion of androstenedione to estrone was not affected. 8-Br-cAMP attenuated the conversion of testosterone to both estradiol-17β and estrone
    http://www.sciencedirect.com/science...a&searchtype=a

    Does this mean anything? No, but why not use it to put together an argument? Amirite? :mentallymasturbates:
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    Originally Posted by PinchTheBear View Post
    The variables are so extensive when you deal a ubiquitous second messenger, e.g.

    http://www.sciencedirect.com/science...a&searchtype=a

    Does this mean anything? No, but why not use it to put together an argument? Amirite? :mentallymasturbates:
    right. more than the conclusion sentence needs to be looked at when examining studies. scientist have a lot of bias at times, and that last sentence in the conclusion/discussion they can form the "data" into whatever they'd like at times.
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    Originally Posted by PinchTheBear View Post
    The variables are so extensive when you deal a ubiquitous second messenger, e.g.

    http://www.sciencedirect.com/science...a&searchtype=a

    Does this mean anything? No, but why not use it to put together an argument? Amirite? :mentallymasturbates:
    LOL one could say forskolin is an aromatase inhibitor then...
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    Originally Posted by alex2992 View Post
    I thought maybe this could be a thread where something could be learned...but it appears arrogance and/or ignorance may prevent that. Its not about me being right - its about what the effects exerted truly are. Im open to all possibilities , with no vested bias either way... just knowledge aquisition.
    Open to all possibilities? With such a short sightedness? Sure...You'll only listen to yourself buddy, you're blindly biased. Talk about arrogence and ignorance.
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