Stoked by Anabolic Innovations

[TheFugitive]

Has anyone tried this product...

[Amino89]

STOKED FAQ, and Logs/Reviews as my review of it would have the potential to be biased.

http://forum.bodybuilding.com/showth...hp?t=107506131

[NoNameNecessary]

There are tons of reviews and logs being done on this product. Many of the results happen to be positive. I, personally, haven't used it and cannot comment on its efficacy. I can, however, state that it appears to be a well-dosed product from a reputable company.

CROWLER, and his representatives, are incredibly knowledgable and would be able to help answer any of your questions.

Additionally, a simple search could have yielded you some answers - search results. In the future, be sure to search before asking your questions; it will help you to be a bit more specific in your questions allowing you to gather better answers.

[quank]

Has anyone tried this product...

http://forum.bodybuilding.com/showth...ghlight=Stoked
http://forum.bodybuilding.com/showth...ghlight=Stoked
http://forum.bodybuilding.com/showth...ghlight=Stoked
http://forum.bodybuilding.com/showth...ghlight=Stoked

[TheFugitive]

Amino89 will stoked help improve cholesterol levels.....

[Amino89]

Amino89 will stoked help improve cholesterol levels.....

I have not seen studies to prove that.

[workingatit46]

Also have not come across any studies to show that.

[workingatit46]

I have found some stuff on the subject

http://www.freepatentsonline.com/6048903.html

Here is some more stuff on it read the 2nd paragraph. The stuff was to large to post here so I will include a link to it

http://www.mdidea.com/products/herbe...l/data.html#03

Specifically trans-resveratrol can help inhibit all three stages of cancer by:
Inducing quinone reductase activity, an enzyme that is capable of detoxifying carcinogens.
Inhibiting cyclo-oxygenase, a substance that causes the production of prostaglandins that stimulate tumor growth, suppress the immune system and activate carcinogens.
Inducing the expression of nitroblue tetazolium reduction activity, a marker of non-specific acid esterase activity and macro****e formation.
Furthermore trans-resveratrol can inhibit the development of cardiovascular disease. This is performed through its ability as an antioxidant to inhibit platelet aggregation and eicosaniod synthesis and its ability to modulate lipoprotein metabolism.

In humans, studies are underway to determine health benefits of resveratrol in cancer and heart disease. Preliminary research results demonstrate that resveratrol may have anti-infective, antioxidant, and anti-inflammatory properties. According to studies involving cancer-prone mice, resveratrol seems to reduce the occurrence of skin tumors. Additional studies suggest that resveratrol is unique because of its ability to battle cancer at all three steps of the cancer process: initiation, promotion, and progression.
Researchers believe that resveratrol is partially responsible for the cholesterol-lowering effects of red wine. Epidemiologic and clinical studies suggest that high consumption of resveratrol-rich foods may result in reduced cardiovascular disease risk, lowered total cholesterol, and lowered LDL cholesterol. Resveratrol's antioxidant properties may again be the mechanism at work in reducing the oxidation of LDL cholesterol. Currently scientists are exploring additional potential health benefits of resveratrol.
Resveratrol doses for inhibition, (i.e. assistance in the prevention) of cancer and cardiovascular disease are 5mg or 10mg daily. Doses for the treatment of the same are 15mg to 30mg daily.
Trans-Resveratrol, the active ingredient that makes up 50 percent of the extract, acts as an antioxidant, anti-mutagenic, and anti-inflammatory by lowering COX-2. It elevates cyclic AMP,which increases metabolic activity in the cell, decreases platelet aggregation, and decreases levels and inhibits oxidation of LDL cholesterol.
Research shows it to be a powerful phytoestrogen that can help maintain normal estrogen activity, reduce hot flashes, balance mood swings, and promote bone density. Resveratrol promotes cardiovascular health and helps prevent premature aging for both sexes.
A recent in vitro study with human cells showed Resveratrol was 99.9 percent effective in halting the reproduction of herpes, shingles, and other viruses and inhibited the growth of cancer cells. Research suggests that 20mg per day of Resveratrol may be able to promote longevity by stimulating the human cell-survival enzyme that is known to increase by restricting caloric intake.


Cancer Chemopreventive Activity and tumor inhibition of Tran-resveratrol from Polygonum cuspidatum extracts:

Cancer is the largest single cause of death in both men and women, claiming over 6 million lives each year worldwide. Chemoprevention, the prevention of cancer by ingestion of chemical agents that reduce the risk of carcinogenesis, is one of the most direct ways to reduce morbidity and mortality. Cancer chemopreventive agents include nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, aspirin, piroxicam, and sulindac, all of which inhibit cyclooxygenase (COX) .
This inhibitory activity is relevant to cancer chemoprevention because COX catalyzes the conversion of arachidonic acid to pro-inflammatory substances such as prostaglandins,which can stimulate tumor cell growth and suppress immune surveillance. In addition, COX can activate carcinogens to forms that damage genetic material.
The process of chemical carcinogenesis can be divided into three general stages, and chemopreventive agents have been categorized according to the stage that they inhibit.
Resveratrol has also been shown to have potent anticancer activity. It modulates the expression of the COX-2 enzyme, which is important in promoting tumorigenesis. It does this by suppressing the activation of the COX-2 gene expression, which leads to the inhibition of the protein kinase C signal transduction pathway. Additionally, resveratrol directly inhibits the activity of COX-2 (Subbaramaiah 1998). In human HepG2 hepatoma cells, resveratrol inhibits enzymes which metabolize arylhydrocarbons to genotoxic metabolites and acts as a competitive agonist of the arylhydrocarbon receptor (Ciolino 1998). This is important because this activity can reduce endothelial cell damage caused by environmental toxicants.
Transresveratrol inhibits cellular events associated with tumor initiation, promotion, and progression. As noted above, the compound was identified on the basis of its ability to inhibit the cyclooxygenase activity of COX-1 (median effective dose ED50 5 15 mM) (Fig. 2A), and this activity correlates with antitumor promotion. Although its inhibitory activity was less than that of certain NSAIDs, such as indomethacin (ED50 5 2.3 mM) (Fig. 2A),it was much greater than that mediated by compounds such as aspirin (ED50 5 880mM). Also, unlike indomethacin and most other NSAIDs, resveratrol inhibited the hydroperoxidase activity of COX-1 (ED50 5 3.7 mM)
Resveratrol-mediated inhibition was specific for the cyclooxygenase activity of COX-1 because there was no discernable activity when oxygen uptake was assessed with COX-2 (Fig. 2A), an inducible form of the enzyme associated with responses such as inflammation, and inhibition of the hydroperoxidase activity of COX-2 (ED50 5 85 mM) was greatly reduced relative to the activity observed with COX-1.
On the basis of these results, researchers investigated the anti-inflammatory activity of resveratrol. In the carrageenan-induced model of inflammation in rats, resveratrol significantly reduced pedal edema both in the acute phase (3 to 7 hours) and in the chronic phase (24 to 144 hours). The edema-suppressing activity of resveratrol was greater than that of phenylbutazone and was similar to that of indomethacin.
Overall, these data demonstrate the potential of resveratrol to inhibit tumor promotion.
Western research has also discovered potential applications of this herb for cancer -- several compounds have shown possible usefulness, including emodin, resveratrol and chrysophanol. These compounds have shown antitumor, antimetastatic, chemopreventive, chemical carcinogenesis-inhibitive, oncogene signal transduction-inhibitive and immunomodulating properties. One study also demonstrated that Hu Zhang was able to increase white blood cells (WBC's, aka leukocytes) in patients with lowered WBC levels due to radiation treatment.

In 1997, resveratrol was reported to be one of the most potent chemopreventive agents able to block all three phases of tumor development that includes initiation, promotion, and progression, induced by the aryl hydrocarbon DMBA. How resveratrol exerts its anticarcinogenic effects is only partially understood. This polyphenol has been shown to inhibit the growth of a wide variety of tumor cells, including leukemic, prostate, breast, and endothelial cells. The ability of resveratrol to induce the expression of CD95L (also called FasL), p53, and p21 may contribute to its growth-inhibitory effects. The suppression of cyclooxygenase-2 (COX-2), cytochrome p450, and c-fos expression by resveratrol may account for its ability to inhibit tumor promotion. Recently, the drug was reported to be a phytoestrogen that behaves as superagonist of estrogen receptor and thereby an inducer of tumor cell proliferation. Its structural similarity with estrogen may also account for its cardioprotective effects.
Because the carcinogenic, inflammatory, and growth-modulatory effects of many chemicals are mediated by NF-B, we hypothesized that the suppression of NF-B activation pathway accounts for resveratrol??s activities. Numerous lines of evidence suggest this possibility. For example, various agents that promote tumorigenesis are known to activate NF-B, including phorbol ester, okadaic acid, and TNF. Experiments in TNF-deficient mice showed that TNF is required for tumor promotion. In addition, several genes that are involved in tumorigenesis, metastasis, and inflammation are regulated by NF-B. A critical role for NF-B in cellular transformation has also been reported.
Most agents that activate NF-B also activate another transcription factor, AP-1. That AP-1 activation mediates tumorigenesis and invasiveness has also been described. The activation of NF-B and AP-1 is regulated by several protein kinases that belong to the mitogen-activated protein kinase (MAPK) family. The activation of NF-B and AP-1 and its associated kinases is in most cases dependent on the production of reactive oxygen species.
In some recent study, scientists tested the hypothesis that the anti-inflammatory and anticarcinogenic effects of resveratrol are mediated through its modulation of NF-B and AP-1 activation, members of the MAPK, and caspase-mediated apoptosis. We demonstrated that resveratrol was a potent inhibitor of NF-B and AP-1 activation. It also inhibited TNF-induced c-Jun N-terminal protein kinase (JNK) and MAPK kinase (MEK) activation and caspase-induced apoptosis. Both reactive oxygen intermediate (ROI) generation and lipid peroxidation induced by TNF were also suppressed by resveratrol.

[koi1214]

Stoked is an excellent test booster.The best on the market.