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    Improve your Mind CognitiveNutrition's Avatar
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    GHB: Powerful Growth Hormone Secretagogue

    GHB: Powerful Growth Hormone Secretagogue
    by Ward Dean MD

    Growth hormone is one of the many hormones that declines dramatically with age (Fig. 1). Growth hormone has multiple functions in the body, including maintaining lean body mass, mobilizing fat, counteracting insulin, enhancing immunity, lowering blood pressure and improving cholesterol levels, increasing energy, and even improving vision. Many physicians now routinely prescribe growth hormone shots for middle-aged and older men and women for their health-enhancing, anti-aging effects. Bodybuilders and athletes have been taking growth hormone for years as an anabolic and performance-enhancing agent.

    A claim about GHB that is frequently made by its supporters (and which is just as roundly denied or ignored by GHB's detractors) is that GHB is a powerful stimulant of growth hormone release by the pituitary.

    If GHB could truly increase growth hormone levels, it would lend credence to the claims of many of its supporters that GHB has profound fat-burning and other anti-aging effects. Let's examine the basis for this belief that GHB may increase growth hormone release.

    GHB increases Growth Hormone in Humans and Experimental Animals

    One of the earliest indications of GHB's potential as a growth hormone stimulator was the study by Oyama and Takiguchi (1970), of the department of anesthesiology, Hirosaki University in Japan. They evaluated the effects of GHB--when used as a general anesthetic--on 10 patients (ranging in age from 14 to 48) undergoing surgery. The scientists found that after infusion of an average of 6 gm GHB, growth hormone levels rose significantly (6 times higher than controls!) and remained elevated for approximately two hours. They also noted no change in insulin or glucose levels. This is very significant, as exogenously administered Growth Hormone (i.e., administered by injections) tends to be diabetogenic, and tends to counteract the glucose-lowering effects of insulin.

    Seven years later Takahara and his colleagues (1977[a]) evaluated the effects of GHB on growth hormone in six males, aged 25-40. Each subject was given 2.5 gm GHB intravenously. Not surprisingly, five of the subjects fell asleep within 20 minutes of the infusion, and slept for 30-150 minutes. Growth hormone levels began to climb after the infusion, reached a peak at 60 minutes, and then gradually declined (Fig. 2). Takahara and his team continued to performed studies on humans regarding growth hormone and GHB, with similar results (1977[b]; 1980)

    In 1980, scientists at the National Institute of Health and Medical Research in France evaluated the GH-stimulating effects of GHB in 20 rats. After intrapertoneal administration of 100 mg/100 gm body weight, GH levels rose significantly (Figure 3) (Bluet-Pajot, et al, 1980). Other studies which confirmed GHB's GH-stimulating effects in humans included those of Yunoki (1982), and Gerra and colleagues (1994).

    In 1997, yet another study was conducted with the specific purpose of determining whether GHB would enhance sleep and increase GH secretion in normal subjects. In this study, eight healthy subjects ranging in age from 24-28 participated. GHB dosages of 2.5 gm, 3.5 gm, and 4.5 gm were administered at bedtime once per week to at least 7 of the 8 subjects. The only "adverse effect" noted by any of the subjects was a feeling of inebriation by five of the subjects. Consistent with previous studies, the duration's of stages III and IV sleep were increased. These are thought to be the most restful and restorative sleep stages, and are also the stages in which growth hormone is maximally released. Figure 4 shows the effect of the low, medium and high doses of GHB on growth hormone, compared with placebo (Van Cauter, et al, 1997) (Fig. 4). Interestingly, Dr. Martin Scharf, one of the co-authors of the study, is one of the most eminent researchers in the world on the beneficial effects of GHB on narcolepsy, (a severe sleep disorder).

    In fact, Van Cauter and Scharf have even applied for a U.S. Patent--"Use of gamma-hydroxybutyrate for the stimulation of sleep-related growth hormone secretion." This patent describes the use of GHB to reestablish normal nighttime growth hormone secretion in adults, by administering GHB just before retiring.

    Long-Term Studies

    Until recently, all of the studies on the growth hormone-releasing effects of GHB had been one-time studies. No one had studied the ability of GHB to stimulate growth hormone after long-term use. Michael Farley, a Florida-based naturopathic physician, has conducted a unique study that will allow us to make some inferences with regard to the long term growth hormone stimulating properties of GHB. Dr. Farley used a dietary supplement (RenewTrient ?) that contained a precursor of GHB-gamma butyrolactone (GBL). For all practical purposes, GHB and GBL have identical biochemical and physiological effects.

    Farley evaluated the effect of GBL on growth hormone, IGF-1, and glucose (glucose can be considered an indirect indicator of GH levels). The test subjects included ten males (aged 28-53). Three had used GBL every night for over one year, while seven had not previously used it.

    Farley noted elevations of growth hormone and IGF1, and reductions in blood sugar in all subjects. However, those who had not previously used GBL had higher levels of growth hormone and IGF1, and greater reductions in blood sugar than the "experienced" GBL users. For example, the average increase from baseline to a peak at 60 minutes ranged from 0.56 to 7.1 NG/ML for the seven GBL "non-users." The four subjects who used GBL for over one year had average values of 0.5 to 2.4 NG/ML, respectively.

    Farley found that test subjects who had the lowest blood glucose levels had the greatest increases in growth hormone. Consequently, he recommends taking GBL on an empty stomach --i.e., about three hours after eating--in order to maximize the release of growth hormone.

    Farley's study, while interesting, leaves us with a few questions, and some suggestions for further study. First, the test was performed in the morning, using a fairly small dose of GBL (0.25 mg/kg). This dose is about half that normally required to induce sleep - confirmed by the fact that none of the subjects fell asleep.

    All of the previous studies on GHB and growth hormone used sleep-inducing doses of GHB. Since GH is released in greatest quantity during Stage III and IV of normal sleep, and since GHB enhances these sleep stages, researchers hypothesized that this was the cause of GHB-stimulated GH release. However, Farley's study showed that GBL enhances GH release even when sleep is not induced. Would the GH release have been even more significant if higher doses had been used?

    Farley's study affirms the long term safety of GBL, as the three long term users suffered no adverse side effects, and maintained a significant growth hormone releasing response. However, since long term daily use did result in a reduction of the growth hormone stimulating effects of GHB, we (Farley and Dean) recommend against chronic daily use of GHB and its precursors (GBL and BD). We believe that consumers of GHB should take a break periodically, and avoid using GHB two or three days each week. This should prevent receptor down-regulation, and optimize the benefits.

    Conclusions

    GHB and its precursors (GBL and BD) are clearly powerful growth hormone secretagogues. A patent has been issued for GHB's use as a growth hormone stimulant - held by one of the leading GHB researchers in the world. A prescription version of GHB is pending imminent approval by the FDA (sic) named Xyrem ? and manufactured by Orphan Medical. These two facts lend credence to the safety and efficacy of GHB in elevating growth hormone, as reported in this review. GHB's growth hormone stimulating effect is just one more of the numerous reasons this miracle nutrient has such a beneficial effect on our health and well-being.

    References:

    Bluet-Pajot, Schaub, C., and Nassiet, J. Growth hormone response to hypoglycemia under gamma hydroxybutyrate narco-analgesia in the rat. Neuroendocrinology, 1978, 26: 141-149.
    Bluet-Pajot, M.T., Schaub, C., Mounier, F., Segalen, A., Duhault, J., and Kordon, C. Monoaminergic regulation of growth hormone in the rat. J Endocr, 1980, 86: 387-396.
    Gerra, G., Marcato, A., Fertonani, A., Avanzini, P., et al. Gamma hydroxybutyric acid (GHB) and neuroendocrine function in humans. Neuroendocrinol Lett, 1994, 16: 1, 55-63.
    Oyama, T., and Takiguchi, M. Effects of gamma hydroxybutyrate and surgery on plasma human growth hormone and insulin levels. Agressologie, 1970, 11: 3, 289-298.
    Takahara, Jiro, Yunoki, Sho, Yakushiji, Wataru, et al. Stimulatory effects of gamma hydroxybutyric acid on growth hormone and prolactin release in humans. J Clin Endocrinol Metab, 1977, 44: 1014-1017.
    Takahara, Jiro, Yunoki, Sho, Yakushiji, Wataru, Yamauchi, J., Ofuji, N., et al. Effects of gamma hydroxybutyric acid and gamma amino beta hydroxybutyric acid on growth hormone, prolactin, LH, FSH, TSH and cortisol secretion in man. Program of the 59th Annual Meeting of the Endocrine Society, Chicago, IL, 1977, 254.
    Takahara, Jiro, Yunoki, Sho, Hosogi, Hidemi, Yakushiji, Wataru, et al. Concomitant increases in serum growth hormone and hypothalamic somatostatin in rats after injection of gamma aminobutyric acid, aminooxyacetic acid, or gamma hydroxybutyric acid. Endocrinology, 1980, 106: 343-347.
    Van Cauter, Eve, Plat, Laurence, Scharf, Martin B., Leproult, Rachel, Cespedes, Sonya, L'Hermite-Baleriaux, Mireille, and Copinschi, Georges. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young men. J Clin Invest, 1997, 100: 3, 745-753.
    Van Cauter, Eve, and Scharf, Martin B. Use of gamma hydroxybutyrate for the stimulation of sleep-related growth hormone secretion. U.S. Patent application 485,059, 7 June 1995, 42 pp.
    Yunoki, Sho. Studies of gamma-aminobutyric acid (GAGA) and its metabolite on the control mechanism of secretion of anterior pituitary hormones. Part II. Effects of gamma-hydroxybutyric acid (GHB) on secretion of anterior pituitary hormones in human subjects. Okayama Igakkai Zasshi, 1982, 94: 899-913.
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  2. #2
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    Cool
    "I Am a God in Amnesia....and Im Just Finally Starting To Remember" the great Sam Rattan, December 21,2012








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    Originally Posted by Vaines View Post
    Cool
    Very.
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  4. #4
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    Originally Posted by CognitiveNutrition View Post
    A prescription version of GHB is pending imminent approval by the FDA (sic) named Xyrem ? and manufactured by Orphan Medical.
    How old is this article? I'm pretty sure Xyrem has been out for a few years (unless I am thinking of another drug )
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    Originally Posted by Xc View Post
    How old is this article? I'm pretty sure Xyrem has been out for a few years (unless I am thinking of another drug )
    You're right it has been out for a few years but not everyone knows that.
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    Originally Posted by CognitiveNutrition View Post
    You're right it has been out for a few years but not everyone knows that.
    I'll read it more indepth tomorrow probably. I remember on SSB people talkng about using it as a cheap Hgh.
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    Originally Posted by Xc View Post
    I'll read it more indepth tomorrow probably. I remember on SSB people talkng about using it as a cheap Hgh.
    It's not cheap but I could see anyone using it for HGH release.
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    Busy Dude Dr.Dave1's Avatar
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    Originally Posted by CognitiveNutrition View Post
    It's not cheap but I could see anyone using it for HGH release.
    it's also a scheduled medication so obtaining xyrem would be pretty tricky in the US unless you have narcolepsy . . .
    GHB is also a date rape drug . . . another reason I doubt it'll be readily available at any point
    Disclaimer: While I have an M.D. the views I express are not to be taken as medical advice under any circumstances. Please check with your own doctor if you want medical advice as he/she has access to your info and can provide the most accurate advice.


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    Personally because of the date rape thing i wouldnt touch it.

    Detective: So then how do you account for a medicine cabinet full off GHB?
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    I tried GHB several times back when you could purchase it from any health store and honestly it never did much for me. I had some friends that absolutely loved the stuff but I was never really that impressed with it. It did seem to induce a good nights sleep, but no more so than low dosed phenibut.
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    Originally Posted by Dr.Dave1 View Post
    it's also a scheduled medication so obtaining xyrem would be pretty tricky in the US unless you have narcolepsy . . .
    GHB is also a date rape drug . . . another reason I doubt it'll be readily available at any point
    Depends on the country your in and your doctor. Well over 100 prescription drugs can be used for date rape but the most common one is otc alcohol. What crimes people can commit with a drug should have no bearing on availablity of the drug. Gov should punish the crime not the compound used.
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    Originally Posted by CognitiveNutrition View Post
    Depends on the country your in and your doctor. Well over 100 prescription drugs can be used for date rape but the most common one is otc alcohol. What crimes people can commit with a drug should have no bearing on availablity of the drug. Gov should punish the crime not the compound used.
    well I would say the majority of individuals here are in the U.S. and it is scheduled here . . . that's my main concern

    obviously there is more than one date rape drug, and yes EtOH is indeed the most plentiful but GHB is the most well known and stereotyped "drug" in that family. For that reason I would not want to be caught with it for risk of litigation . . . although I'm not entirely sure if one would face higher penalties for having GHB (a date rape drug) or GH . . . fortunately it's not an issue I am worried about
    Disclaimer: While I have an M.D. the views I express are not to be taken as medical advice under any circumstances. Please check with your own doctor if you want medical advice as he/she has access to your info and can provide the most accurate advice.


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    beside the fact that GHB is illegal, it might be of interest that it does not only cause GH release but also increased prolactin levels.

    and believe me, prolactin is nothing that male bodybuilders really want.
    prolactin inhibits testosterone release and GH without androgens is pretty much worthless for protein synthesis.


    J Clin Endocrinol Metab. 1977 May;44(5):1014-7.

    Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

    Takahara J, Yunoki S, Yakushiji W, Yamauchi J, Yamane Y.

    A dose of 2.5 g of gamma-hydroxybutyric acid (GHB) was administered intravenously to 6 healthy male volunteers. A significant increase in plasma GH was observed at 30, 45, 60 and 90 min after injection. The plasma prolactin level increased significantly at 45 and 60 min after GHB injection. These responses were not found after the saline vehicle injection in the same subjects. It is conceivable that GHB could modify the release of serotonin from the nerve terminals and then stimulate the release of GH and prolactin.
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    GHB is a serious drug, and there's pretty good reason it was "swept" under the rug so-to-say on bodybuilding forums.

    I just don't want young kids (read the majority of visitors to this site) to think GHB is all good without side effects.
    "Like those in the valley behind us, most people stand in sight of the spiritual mountains all their lives and never enter them, being content to listen to others who have been there and thus avoid the hardships."
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    Originally Posted by u5711 View Post
    GHB is a serious drug, and there's pretty good reason it was "swept" under the rug so-to-say on bodybuilding forums.

    I just don't want young kids (read the majority of visitors to this site) to think GHB is all good without side effects.
    excellent. reps on recharge!
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    I have read through this....and to be honest I just DON'T see the point of using a Schedule 1 drug when you can obtain HGH as easily and suffer far less penalties if you are caught with it!

    The penalties for GHB are serious ****

    First Offense: Not more that 20 yrs. If death or serious injury, not less than 20 yrs, or more than Life. Fine $1 million if an individual, $5 million if not an individual.
    Second Offense: Not more than 30 yrs. If death or serious injury, not less than life. Fine $2 million if an individual, $10 million if not an individual

    Directly using HGH is usually more of a state penalty rather than federal, as I cannot even find Federal law that places it as a controlled substance.
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    Originally Posted by Dr.Dave1 View Post
    well I would say the majority of individuals here are in the U.S. and it is scheduled here . . . that's my main concern

    obviously there is more than one date rape drug, and yes EtOH is indeed the most plentiful but GHB is the most well known and stereotyped "drug" in that family. For that reason I would not want to be caught with it for risk of litigation . . . although I'm not entirely sure if one would face higher penalties for having GHB (a date rape drug) or GH . . . fortunately it's not an issue I am worried about
    Well it's easy to get a prescription if you have a good doctor.
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    Originally Posted by :P View Post
    beside the fact that GHB is illegal, it might be of interest that it does not only cause GH release but also increased prolactin levels.

    and believe me, prolactin is nothing that male bodybuilders really want.
    prolactin inhibits testosterone release and GH without androgens is pretty much worthless for protein synthesis.
    It's legal with a prescription. You seem to miss that fact.

    Taking deprenyl with it can easily block any prolactin release.
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    Originally Posted by u5711 View Post
    GHB is a serious drug, and there's pretty good reason it was "swept" under the rug so-to-say on bodybuilding forums.

    I just don't want young kids (read the majority of visitors to this site) to think GHB is all good without side effects.
    GHB is very safe when used as directly. Sadly some idiots abused it and and used it improperly.

    Like any supplement/drug it can be used safely without any serious side effects.
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    Originally Posted by v4lu3s View Post
    I have read through this....and to be honest I just DON'T see the point of using a Schedule 1 drug when you can obtain HGH as easily and suffer far less penalties if you are caught with it!

    The penalties for GHB are serious ****

    First Offense: Not more that 20 yrs. If death or serious injury, not less than 20 yrs, or more than Life. Fine $1 million if an individual, $5 million if not an individual.
    Second Offense: Not more than 30 yrs. If death or serious injury, not less than life. Fine $2 million if an individual, $10 million if not an individual

    Directly using HGH is usually more of a state penalty rather than federal, as I cannot even find Federal law that places it as a controlled substance.

    It's Schedule 3 with a prescription same as HGH.

    http://www.deadiversion.usdoj.gov/drugs_concern/hgh.htm
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    Originally Posted by CognitiveNutrition View Post
    Well it's easy to get a prescription if you have a good doctor.
    a good doctor? . . . it's only FDA approved indications are excessive daytime sleepiness / narcolepsy . . . not a very large population
    So unless you have any of these conditions a good doctor should not prescribe it for you
    Disclaimer: While I have an M.D. the views I express are not to be taken as medical advice under any circumstances. Please check with your own doctor if you want medical advice as he/she has access to your info and can provide the most accurate advice.


    www.pubmed.gov . . . gotta love it
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    Unhappy Hey hey now...

    Originally Posted by CognitiveNutrition View Post
    Well it's easy to get a prescription if you have a good doctor.
    It's easy to get a prescription if you have a doctor who lacks ethics. No self respecting doctor would prescribe medications based off a request (with no medical evidence of pathology)-- they would lose their license or certainly be reprimanded by their respective board by which they were certified.

    Nonetheless, I'm surprised that it hasn't been mentioned that elevated GH levels [which would be the result of GH secretagogue administration] are NOT associated with truly "better health" ("beneficial effect on our health and well being"). Studies have been done (in mice) where they were genetically altered to lack GH expression. The studies found that the control group (aka. normal mice) lived ~2years. The genetically altered mice (GH negative) lived 3.5years. The increased lifespan is believed to be associated with a decreased metabolism (since GH maintains certain aspects of the body's metabolism) and therefore somehow the body is able to sustain itself for a longer period of time.

    It *was* originally thought that GH was the fountain of youth since it has been shown that GH levels decrease as we get older. Therefore, increase GH levels and we'll get our youthful energy back, right? Well, it may seem that way when you're taking it (partially due to the placebo effect), but the long term consequences of increasing your cellular metabolism (without the body/"biologic machinery" of youth) are a decreased lifespan.

    Additionally, prolonged elevated GH is associated with acromegaly. Look at a picture of a young Sylvester Stallone compared to a recent one. His features are characteristic of acromegaly (not as drastic as patients with a GH secreting tumor, but the enlarged features are still present. This occurs because certain tissues, such as those in your nose/chin/ears/hands are always responsive to GH. Other tissues, such as bone, have a decreased response to GH post-puberty.). Stallone openly praises GH and admits to/supports using it, hence the reason why I use him as an example.

    Whenever you alter endocrine levels there are always consequences in one way or another.
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    Originally Posted by CognitiveNutrition View Post
    It's legal with a prescription. You seem to miss that fact.

    Taking deprenyl with it can easily block any prolactin release.
    nobody from the bodybuilding crowd who does not suffer from narcolepsy will ever get a valid prescription for this stuff, if their doctor is halfway responsible and ethical.

    you apparently believe that if your henchman Lee Crost prescribes you every sh!t, that all other halfway serious doctors are going to do the same?

    where is the rationale for taking GHB for GH-release when you can achieve same (or better) results with other amino acids that are perfectly legal and virtually side-effect-free?

    the problem with you is that you repeatedly prompt people to take illegal drugs, (or to get very dubious prescriptions).
    this has been the case with hallucinogenics, with marijuana / cannbinoids, and now it is GHB. what will be next? heroin? shame on you!

    to all people who read this thread: don't let this hack seduce you to even remotely think about illegal drugs that will bring you more damage and hassle than benefits.
    Last edited by :P; 04-13-2008 at 05:04 AM.
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    Originally Posted by CognitiveNutrition View Post
    GHB is very safe when used as directly. Sadly some idiots abused it and and used it improperly.

    Like any supplement/drug it can be used safely without any serious side effects.
    the only idiocy I can see here is when irresponsible people shamelessly claim that illegal drugs such as GHB can be "safely used without ANY serious side effects".

    GHB has the same potential for tolerance and addiction as benzodiazepines, but according to you we all should anyways be taking benzodiazepines, right?

    it can cause severe withdrawal symptoms when taken regularly. and single doses that are above a certain threshold can be dangerous as well.

    it would be completely retarded to prefer such a dangerous drug to other side-effect-free GH enhancers.


    BTW: as much as amphetmines have a very different spectrum of side-effects in ADHD patients as opposed to normal people, narcolepsy-drugs are usually much better tolerated by narcolepsia patients when comapred to normal healthy individuals.
    Last edited by :P; 04-13-2008 at 05:04 AM.
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    Thumbs down

    Originally Posted by CognitiveNutrition View Post
    Taking deprenyl with it can easily block any prolactin release.

    uuuups.... it does not only increase prolactin but cortisol levels as well:

    J Clin Invest. 1997 Aug 1;100(3):745-53.

    Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.

    Van Cauter E, Plat L, Scharf MB, Leproult R, Cespedes S, L'Hermite-Bal?riaux M, Copinschi G.
    Department of Medicine, University of Chicago, Illinois 60637, USA. evacauter@medicine.bsd.uchicago.edu

    The aim of this study was to investigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave (SW) sleep in normal subjects, would simultaneously enhance sleep related growth hormone (GH) secretion. Eight healthy young men participated each in four experiments involving bedtime oral administration of placebo, 2.5, 3.0, and 3.5 g of GHB. Polygraphic sleep recordings were performed every night, and blood samples were obtained at 15-min intervals from 2000 to 0800. GHB effects were mainly observed during the first 2 h after sleep onset. There was a doubling of GH secretion, resulting from an increase of the amplitude and the duration of the first GH pulse after sleep onset. This stimulation of GH secretion was significantly correlated to a simultaneous increase in the amount of sleep stage IV. Abrupt but transient elevations of prolactin and cortisol were also observed, but did not appear to be associated with the concomitant stimulation of SW sleep...

    But you surely have something in your company's product line that will suppress elevated cortisol levels as well, right?
    but be aware, you would need to have something really powerfull, since the other illegal drugs that you reccomend to people (such as marijuana) also elevate cortisol levels.
    Last edited by :P; 04-13-2008 at 07:31 AM.
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    GHB is a great growth hormone releaser. A decade ago there was a whole protocol on how to use it and avoid any of the negatives.

    When used proerly it is no way dangerous or addictive. The biggest problem was that it made people feel good. So lots of people started abusing it as a recreational drug.

    The whole date rape thing was minimal until it started being used as one of the reasons for making GHB illegal. The main reason GHB was made illegal is that it is non-patentable and a great sleep aid. Since it became illegal, at least six new sleep drugs have reached the market doing billions in sales. None of these drugs work as well or as safely as GHB.

    Now, it is massively illegal and highly controlled. Prescription information is sent to the FDA and all prescriptions can be subjected to individual review.
    Any doctor prescribing it without proper backup will get their right to write prescription revoked. Nobody in their right mind would take the risk.

    HGH is not a schedule 3 drug. It is illegal to sell without a presciption but it is not illegal to have.
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    Originally Posted by jhalt View Post
    GHB is a great growth hormone releaser. .
    give me a break. a transient 200% increase of GH levels is really far from being outstanding. what is the physioloical consequence if my GH-levels are doubled for 90 minutes? without concomitant IGF-1 increase? what will I gain from that? most probably nothing, nada!

    2 g of oral glutamine have been shown to do the same. and 3g of plain oral GABA appears to be even more effective than that.
    and do I need to mention that physical exercise increases GH levels up to tenfold more than that? without prolactin!

    GHB or its new derivative natrium-oxybate may be a great drug for narcoleplsia-patients as it can greatly reduce the frequency and severity of kataplexy. and that's it. there is no rationale for GHB use outside of narcolepsy.
    Last edited by :P; 04-13-2008 at 09:56 AM.
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    Originally Posted by Dr.Dave1 View Post
    a good doctor? . . . it's only FDA approved indications are excessive daytime sleepiness / narcolepsy . . . not a very large population
    So unless you have any of these conditions a good doctor should not prescribe it for you
    Doctors can prescribe any drug for any use. Doctors should and can prescribe many drugs for offlabel uses, due to clinically proven effects that the drug never got an FDA approval for.
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    Originally Posted by jhalt View Post
    GHB is a great growth hormone releaser. A decade ago there was a whole protocol on how to use it and avoid any of the negatives.

    When used proerly it is no way dangerous or addictive. The biggest problem was that it made people feel good. So lots of people started abusing it as a recreational drug.

    The whole date rape thing was minimal until it started being used as one of the reasons for making GHB illegal. The main reason GHB was made illegal is that it is non-patentable and a great sleep aid. Since it became illegal, at least six new sleep drugs have reached the market doing billions in sales. None of these drugs work as well or as safely as GHB.

    Now, it is massively illegal and highly controlled. Prescription information is sent to the FDA and all prescriptions can be subjected to individual review.
    Any doctor prescribing it without proper backup will get their right to write prescription revoked. Nobody in their right mind would take the risk.

    HGH is not a schedule 3 drug. It is illegal to sell without a presciption but it is not illegal to have.
    In March 2007, a bill was introduced into the U.S. Senate to amend the CSA and to add hGH to schedule III.
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    Originally Posted by EVentura84 View Post
    It's easy to get a prescription if you have a doctor who lacks ethics. No self respecting doctor would prescribe medications based off a request (with no medical evidence of pathology)-- they would lose their license or certainly be reprimanded by their respective board by which they were certified.

    Nonetheless, I'm surprised that it hasn't been mentioned that elevated GH levels [which would be the result of GH secretagogue administration] are NOT associated with truly "better health" ("beneficial effect on our health and well being"). Studies have been done (in mice) where they were genetically altered to lack GH expression. The studies found that the control group (aka. normal mice) lived ~2years. The genetically altered mice (GH negative) lived 3.5years. The increased lifespan is believed to be associated with a decreased metabolism (since GH maintains certain aspects of the body's metabolism) and therefore somehow the body is able to sustain itself for a longer period of time.

    It *was* originally thought that GH was the fountain of youth since it has been shown that GH levels decrease as we get older. Therefore, increase GH levels and we'll get our youthful energy back, right? Well, it may seem that way when you're taking it (partially due to the placebo effect), but the long term consequences of increasing your cellular metabolism (without the body/"biologic machinery" of youth) are a decreased lifespan.

    Additionally, prolonged elevated GH is associated with acromegaly. Look at a picture of a young Sylvester Stallone compared to a recent one. His features are characteristic of acromegaly (not as drastic as patients with a GH secreting tumor, but the enlarged features are still present. This occurs because certain tissues, such as those in your nose/chin/ears/hands are always responsive to GH. Other tissues, such as bone, have a decreased response to GH post-puberty.). Stallone openly praises GH and admits to/supports using it, hence the reason why I use him as an example.

    Whenever you alter endocrine levels there are always consequences in one way or another.
    I disagree 100%. Human enhancement and antiaging purposes are valid reasons to prescribe any drug for an offlabel use.
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