I had a neurotransmitter test done back in August 30, 2007. It was confirmed on this test that I was substantially deficient in Glutamine.
Day = 150-400
Night = 100-350
Day = 130-650
Night = 100-500
I did some research on Glutamine deficiency, and I read that it causes loss of lean mass. As far as the causes, from what I've read, Glutamine deficiency can be caused by severe trauma, infection or metabolic stress induced by a catabolic state or extreme physical exertion. Some sites say that it can be cause by fasting, starvation, and doing too much cardio.
There was one period of time when I did tons of cardio 5-6 days per week. This was 5.5-6.0 years ago. The reason I did tons of cardio then was to lose fat that I gained from Depakote, and anti-convulsant given for bipolar disorder. That drug commonly causes weight gain as a side effect. Also, when I took that drug, I would cycle frequently from binging and fasting as that drug tended to cause an insatiable appetite. So, I wonder if these things could have depleted my Glutamine levels, and my Glutamine levels simply never returned back up to normal even after all of these years.
Over late 2005 throughout half of 2006, I used whey protein fairly frequently, which averages 4 grams of Glutamine per scoop, but apparently, this wasn't enough to get my levels to optimal range.
I read that taking Glutamine can stall muscle loss & fat gain, and I believe this especially applies if you were deficient in it to start with and had lower than average levels of lean mass (for someone your weight/height) as a result. Being under-muscled for my given weight/height has always been a problem for me.
I started taking Glutamine in the middle of February to aggressively correct the deficiency, and since then I've gained almost 4 pounds, from 124 to 128. I started Panthothenic Acid as well because there's a probability that I have problems with adrenal insufficiency. I know the weight gain was all lean mass because I was gaining weight on substantially fewer Calories than what it normally takes for me to gain weight.
Normally, at my activity level, I have to go above 2700-2800 to gain any kind of weight; 3000 Calories per day yields only 1/3-1/2 pound per week. However, at that level this time, I was gaining at a rate of almost 1.5 lbs per week as opposed to the normal 0.33-0.50 lb per week at that level.
At 2650 Calories, I was gaining 1.3 pounds per week, which reflects a 650 Calorie surplus. This would've falsely showed that I was burning only 2000 Calories. If someone would've seen these numbers, then he would have gotten the impression that Glutamine and Pantothenic Acid slow your metabolism down. But in reality, I was actually burning at least 2700. So, I believe my body could've been regenerating lean mass. I read that muscle is 70% water.
Also, after I started those two supplements, my appetite increased by alot, so I assumed that since my body needed to regenerate lost lean mass (presumably due to the Glutamine deficiency), it started to demand more Calories than before. Also, it's been known that if your metabolism rate increases, then your appetite increases along with it. Some research shows that those two supplements can actually help metabolism. So, I wonder if my real metabolism rate could've increased as well, and my appetite went up along with it, too.
Has anyone else had a Glutamine deficiency like this? If so, how did this deficiency affect your progress in achieving your body composition goals?
Thread: Glutamine Deficiency