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Originally Posted by smc
Still not sure about the 4-chloro alteration in t-bol.. I really don't know much about chemistry, and need to get schooled up a bit.
Does it 100% stop the drug from interacting with aromatase like it's claimed?
What is the actual anabolic/androgenic rating of this drug?
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Yes. A substitition on the A (or 1st) ring will inhibit action of aromatase.
Theres still a few molecules that are interacting, as with always things in the chemical world are constantly flexing and shifting, but lets not talk about 10 molecules per mole. Non-aromatizable. Estrogenis would be an aromatic (alternating conjugated double bonds) on the first ring. Any substitution here disrupts these double bonds from forming. Generally, however, a hydroxyl group at one of these locations will NOT disrupt aromatization, as you can easily dehydrate the OH to form a bond it self.
N4cer, a while back you said steroid half lives are linear not exponential. Explain please? I've been looking into this-no such thing as a linear half life in anything I've ever read and wasnt able to find any such term 'linear halflife'.
In such is the case, I'm assuming HALF the substance (original amount X, so X/2) would be gone in half life time, then an additional X/2 would be gone after the next period. This makes no sense, certainly this would be linear, but explain how things would build up in our blood stream then to such a degree higher than the administered dose?
Not sayin your wrong, just never heard of this...?