11-OXO Frequently Asked Questions

Hypertrophik · 03-11-2008, 08:00 AM

What is 11 OXO?

11 OXO is adrenosterone which is a hormone produced in the adrenal glands under the influence of adrenocorticotropic hormone (ACTH).

How does 11 OXO work?

11 OXO works in two ways. First, it is a prohormone to 11-ketotesterone which is a non-aromatizing analog of testosterone. It shares many of testosterone's benefits such as increased libido and increased muscle mass.

11 OXO also works by selectively inhibiting the function of the 11beta-hydroxysteroid dehydrogenase type1 reductase (11HSD1R), an enzyme responsible for converting cortisone to cortisol in target tissues such as fat, liver, and muscle. 11 OXO simply occupies the enzyme, preventing cortisone from accessing it. This is known as competitive inhibition. If cortisone cannot access 11HSD1R then it won't have the opportunity to be converted to cortisol at the target tissue. The nice thing about 11 OXO is that it selectively acts on the 11HSD1R enzyme. Thus, 11 OXO offers a method of controlling the negative actions of cortisol on the body without blocking cortisol's vital functions necessary for life.

For more Info : http://www.ergopharm.net/products_11oxo_article.php

11 OXO useful only for cutting? What if I'm bulking?

Cutting is its forte, however it is still very good for bulking. 11 OXO will help minimize fat deposition while on a hypercaloric diet.

Is 11 OXO suppressive?

11 OXO may cause suppression at high doses due to the fact that it converts to 11-ketotestosterone, a potent androgen. This is exhibited especially at higher doses, 6+ caps/day. Always make sure to run the proper PCT after each cycle.

Is 11 OXO estrogenic?

11 OXO does not aromatize and it has a very low intrinsic estrogenic potential. In fact, in a study comparing it to 18 other common androgenic steroids it showed the lowest estrogenic potency (as measured through uterotrophic activity).

Do I need liver support while on cycle?

No, 11 OXO is not a methylated androgen and thus does not pose any substantial strain on the liver.

Any rebound in cortisol after use of 11 OXO?

There are no outward signs of cortisol rebound when reasonable dosages are utilized.

How long should I run 11 OXO?

It is suggested that you run 11 OXO no longer than 8 weeks.

Can I stack 11OXO with other prohormones?

11 OXO works quite well on its own however one can stack with other hormonal products. Of course post cycle therapy (PCT) becomes more of a necessity when other hormonal products are utilized.

Do I need PCT after I'm done taking 11 OXO?

In doses under 3 capsules per day it is not required. In doses over 3 capsules a day but under 6 capsules a day it is recommended. In doses over 6 caps a day it is highly recommended.
Refer to Cycle Suggestions

What is 11 OXO's half life?

11 OXO's pharmacokinetic profile should be similar to non-methyl prohormones. Peak blood levels should be attained in about an hour after ingestion. Then it should start to decline returning to baseline after 4 to 5 hours.

Should I take 11 OXO before bed?

It is suspected that the morning cortisol rise is an important part of arousal so the user may not want to interfere with that by taking it night before. It may not make any difference but if the user had to make a choice then it is recommended that they avoid evening dosing.

Should I take 11 OXO with meals?

It is recommended to take 11 OXO with a meal containing some fat.

Does 11 OXO have any side effects?

Potential side effects with 11 OXO are the same as with all prohormone products. Most common would be acne, acceleration of male pattern baldness (if genetically susceptible), and increased or decreased sex drive. Also, increased appetite has been reported.

Suggested Cycles:

Low Dose:
Day 1-40: 11 OXO 1 capsule 3 times per day with meals
Day 41-60: 6-OXO 3 capsules 2 times per day with breakfast and dinner

Higher Dose:
Day 1-20: 11 OXO 2 capsules 3 times per day with meals
Day 41-40: 6-OXO 3 capsules 2 times per day with breakfast and dinner

An interesting alternative to this method is the stagger method. A staggered cycle can take the form of the following:

Stagger Dose:

Day 1-4: 11 OXO 2 capsules 3 times per day with meals
Day 5-8: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 9-12: 11 OXO 2 capsules 3 times per day with meals
Day 13-16: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 17-20: 11 OXO 2 capsules 3 times per day with meals
Day 21-24: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 25-28: 11 OXO 2 capsules 3 times per day with meals
Day 29-32: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 33-36: 11 OXO 2 capsules 3 times per day with meals
Day 37-40: 6-OXO 3 capsules 2 times per day with breakfast and dinner

Sandman82 · 03-11-2008, 08:02 AM

Great post brother!!!

Hypertrophik · 03-11-2008, 08:05 AM

Answers provided by PA and the ErgoPharm board reps:

Will 11 OXO affect blood sugar levels? I Don't want my blood sugar levels to tank, especially while under the bar!

This cannot be predicted. While there is no cause to think there would be any dramatic acute hypoglycemic effect, the possibility exists that significant changes in glucose tolerance may occur in some individuals

Hypertrophik · 03-11-2008, 08:06 AM

11-oxo metabolites:

What are the names of the metabolites or can you point me to a place that I can find them? I looked and can't find them. :

11beta-hydroxyandrostenedione and 11-ketotestosterone were the one i was referring to. The 11-oxygen atom appears to interfere with aromatization. however 11-alpha hydroxy androgens do aromatize to a slight extent. Luckily, metabolites with this functional group constitute an insignificantly minor percentage with 11-OXO

Hypertrophik · 03-11-2008, 08:08 AM

11-oxo and Thyroid:

Well would it be okay to stack 11-oxo with thyrotabs? Would these cancel each other out in any way?
Be careful because 11-oxo may increase endogenous thyroid production. stuff i have read indicates that when you suppress cortisol T3 levels go up

I am taking Synthroid to treat my underactive thyroid glands, what kind of interaction 11-OXO will have with Synthroid?

As I stated above, i am not entirely sure about 11-oxo and thyroid. it seems to make me feel hot so it may be thyrotropic

Hypertrophik · 03-11-2008, 08:12 AM

Cortisol Modulation with higher doses:

I was wondering that if you go for the higher end dosage at 6 caps a day, at which the PH like effects are amplified, does the cortisol modulation effect diminish, or can you still expect a combination of both effects?

It will not diminish, it may increase

11-oxo's effects on adrenal glands / Cortisol rebound

Will 11-oxo have any negative impact on the adrenal glands since we are messing with our cortisol levels ?and is there any sort of rebound effect with cortisone/cortisol levels when discontinuing it?

Good question because it allows me to once again stress the point that this product does not alter blood levels of cortisol and cortisone to any great extent. therefore the hypothalimc pituitary adrenal axis is not affected very much. It only effects the level of cortisol at the target tissues themselves. This minimizes the potential for cortisol rebound

11-oxo and subcutaneous/visceral fat

What type of fat does 11-oxo target ?

11-oxo targets visceral fat (the fat between your vital organs) more so than subcutaneous. that fat is subcutaneous

Beejis60 · 03-11-2008, 09:35 AM

It's looking good in here!! Great compilation of FAQs!!!

Blackjackcat · 03-11-2008, 12:29 PM

Its about time the 11 OXO FAQ came out. : ) I am up to 8 caps a day and I think this is the number for me. No side effects or suppression so far(that I can tell). First PH that I have tried and I am glad I picked this one.

DOMESKI · 03-12-2008, 05:05 AM

SHWWWWEEEET write up mang! just received this link. much needed thread.

hehe i have trouble stopping this stuff. could be one of the best ergogenic aids i've ever used.

jeremyleinen · 03-12-2008, 06:39 AM

I just ordered some of this last night. Looking forward to see how it goes.

force_ · 03-12-2008, 06:43 AM

Just for the hell of it Im going to throw this one out there- is there any point taking 6OXO and 11 OXO at the same time?

Just curious.

F.

Blackjackcat · 03-12-2008, 07:02 AM

Quote:

Originally Posted by force_

Just for the hell of it Im going to throw this one out there- is there any point taking 6OXO and 11 OXO at the same time?

Just curious.

F.

There is a staggered way in the FAQ.

Beejis60 · 03-12-2008, 07:59 AM

Quote:

Originally Posted by force_

Just for the hell of it Im going to throw this one out there- is there any point taking 6OXO and 11 OXO at the same time?

Quote:

Originally Posted by Blackjackcat

There is a staggered way in the FAQ.

The stagger dose is the best bet, but I would stick with using 11-OXO followed by 6-OXO as PCT.

Cable Curling CincoUno · 03-12-2008, 08:09 AM

Quote:

Originally Posted by Hypertrophik

What is 11 OXO?

11 OXO is adrenosterone which is a hormone produced in the adrenal glands under the influence of adrenocorticotropic hormone (ACTH).

How does 11 OXO work?

11 OXO works in two ways. First, it is a prohormone to 11-ketotesterone which is a non-aromatizing analog of testosterone. It shares many of testosterone's benefits such as increased libido and increased muscle mass.

11 OXO also works by selectively inhibiting the function of the 11beta-hydroxysteroid dehydrogenase type1 reductase (11HSD1R), an enzyme responsible for converting cortisone to cortisol in target tissues such as fat, liver, and muscle. 11 OXO simply occupies the enzyme, preventing cortisone from accessing it. This is known as competitive inhibition. If cortisone cannot access 11HSD1R then it won't have the opportunity to be converted to cortisol at the target tissue. The nice thing about 11 OXO is that it selectively acts on the 11HSD1R enzyme. Thus, 11 OXO offers a method of controlling the negative actions of cortisol on the body without blocking cortisol's vital functions necessary for life.

For more Info : http://www.ergopharm.net/products_11oxo_article.php

11 OXO useful only for cutting? What if I'm bulking?

Cutting is its forte, however it is still very good for bulking. 11 OXO will help minimize fat deposition while on a hypercaloric diet.

Is 11 OXO suppressive?

11 OXO may cause suppression at high doses due to the fact that it converts to 11-ketotestosterone, a potent androgen. This is exhibited especially at higher doses, 6+ caps/day. Always make sure to run the proper PCT after each cycle.

Is 11 OXO estrogenic?

11 OXO does not aromatize and it has a very low intrinsic estrogenic potential. In fact, in a study comparing it to 18 other common androgenic steroids it showed the lowest estrogenic potency (as measured through uterotrophic activity).

Do I need liver support while on cycle?

No, 11 OXO is not a methylated androgen and thus does not pose any substantial strain on the liver.

Any rebound in cortisol after use of 11 OXO?

There are no outward signs of cortisol rebound when reasonable dosages are utilized.

How long should I run 11 OXO?

It is suggested that you run 11 OXO no longer than 8 weeks.

Can I stack 11OXO with other prohormones?

11 OXO works quite well on its own however one can stack with other hormonal products. Of course post cycle therapy (PCT) becomes more of a necessity when other hormonal products are utilized.

Do I need PCT after I'm done taking 11 OXO?

In doses under 3 capsules per day it is not required. In doses over 3 capsules a day but under 6 capsules a day it is recommended. In doses over 6 caps a day it is highly recommended.
Refer to Cycle Suggestions

What is 11 OXO's half life?

11 OXO's pharmacokinetic profile should be similar to non-methyl prohormones. Peak blood levels should be attained in about an hour after ingestion. Then it should start to decline returning to baseline after 4 to 5 hours.

Should I take 11 OXO before bed?

It is suspected that the morning cortisol rise is an important part of arousal so the user may not want to interfere with that by taking it night before. It may not make any difference but if the user had to make a choice then it is recommended that they avoid evening dosing.

Should I take 11 OXO with meals?

It is recommended to take 11 OXO with a meal containing some fat.

Does 11 OXO have any side effects?

Potential side effects with 11 OXO are the same as with all prohormone products. Most common would be acne, acceleration of male pattern baldness (if genetically susceptible), and increased or decreased sex drive. Also, increased appetite has been reported.

Suggested Cycles:

Low Dose:
Day 1-40: 11 OXO 1 capsule 3 times per day with meals
Day 41-60: 6-OXO 3 capsules 2 times per day with breakfast and dinner

Higher Dose:
Day 1-20: 11 OXO 2 capsules 3 times per day with meals
Day 41-40: 6-OXO 3 capsules 2 times per day with breakfast and dinner

An interesting alternative to this method is the stagger method. A staggered cycle can take the form of the following:

Stagger Dose:

Day 1-4: 11 OXO 2 capsules 3 times per day with meals
Day 5-8: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 9-12: 11 OXO 2 capsules 3 times per day with meals
Day 13-16: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 17-20: 11 OXO 2 capsules 3 times per day with meals
Day 21-24: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 25-28: 11 OXO 2 capsules 3 times per day with meals
Day 29-32: 6-OXO 3 capsules 2 times per day with breakfast and dinner
Day 33-36: 11 OXO 2 capsules 3 times per day with meals
Day 37-40: 6-OXO 3 capsules 2 times per day with breakfast and dinner

shouldnt the part i bolded on the higher dosage suggestion be changed to days 1-40?

Hypertrophik · 03-12-2008, 08:25 AM

Quote:

Originally Posted by Cable Curlin' CincoUno

shouldnt the part i bolded on the higher dosage suggestion be changed to days 1-40?

Yes, thank you !

Cable Curling CincoUno · 03-12-2008, 08:49 AM

Quote:

Originally Posted by Hypertrophik

Yes, thank you !

hahaha no problem. i dont know much about phs but i figured a 20 day delayed pct doesn't make all that much sense lol

Hypertrophik · 03-12-2008, 08:53 AM

Quote:

Originally Posted by Cable Curlin' CincoUno

hahaha no problem. i dont know much about phs but i figured a 20 day delayed pct doesn't make all that much sense lol

lol word !

u5711 · 03-13-2008, 04:07 AM

Quote:

Originally Posted by Hypertrophik

Low Dose:
Day 1-40: 11 OXO 1 capsule 3 times per day with meals
Day 41-60: 6-OXO 3 capsules 2 times per day with breakfast and dinner

What is the rationale behind doubling your dose for the last 1/3 of the cycle?

Also, it seems like "Low Dose" is not an accurate description of this method seeing as how you start at low dose and finish at a moderate-high dose.

Hypertrophik · 03-13-2008, 06:35 AM

Quote:

Originally Posted by u5711

What is the rationale behind doubling your dose for the last 1/3 of the cycle?

Also, it seems like "Low Dose" is not an accurate description of this method seeing as how you start at low dose and finish at a moderate-high dose.

Where did you see the 11oxo dose doubled? 11oxo will be used at 3 caps perday throughout the cycle (no change). I think you are refering to 6-oxo that doubled, thats part of PCT and is the standard method of usage.

u5711 · 03-13-2008, 06:57 AM

Quote:

Originally Posted by Hypertrophik

Where did you see the 11oxo dose doubled? 11oxo will be used at 3 caps perday throughout the cycle (no change). I think you are refering to 6-oxo that doubled, thats part of PCT and is the standard method of usage.

Bleh! You're right lol, I missed the critical 6

.

With that in mind, what's your thoughts on leaving the 6oxo (PCT) out. I believe PA has said a few times that 11-oxo isn't very suppressive at low doses and PCT isn't necessary. I realize it's not the best recommendation, but I would think PA has a good reason for it (i.e. not much to be gained from such trivial suppression?).

Hypertrophik · 03-13-2008, 07:40 AM

Quote:

Originally Posted by u5711

Bleh! You're right lol, I missed the critical 6

.

With that in mind, what's your thoughts on leaving the 6oxo (PCT) out. I believe PA has said a few times that 11-oxo isn't very suppressive at low doses and PCT isn't necessary. I realize it's not the best recommendation, but I would think PA has a good reason for it (i.e. not much to be gained from such trivial suppression?).

PCT for doses under 3 caps per day is not really required due to the fact that you mentioned, very low suppression at this dosing scheme. Anything above 3 i would run PCT.

phate5180 · 03-13-2008, 09:07 AM

Quote:

Originally Posted by Hypertrophik

PCT for doses under 3 caps per day is not really required due to the fact that you mentioned, very low suppression at this dosing scheme. Anything above 3 i would run PCT.

Yes but 6-oxo extreme works nice. I've liked it so far and I'm probably a week or so into it. Def feel a nice test boost.

Hypertrophik · 03-13-2008, 09:09 AM

Quote:

Originally Posted by phate5180

Yes but 6-oxo extreme works nice. I've liked it so far and I'm probably a week or so into it. Def feel a nice test boost.

Thats great, glad you like it! Thanks for your input.

BuckeyeMuscle · 03-13-2008, 09:14 AM

Hyper, I have a new question for your FAQ.....Can you hook me up with 6 bottles when on spring break when I see you?

Hypertrophik · 03-13-2008, 11:20 AM

Quote:

Originally Posted by BuckeyeMuscle

Hyper, I have a new question for your FAQ.....Can you hook me up with 6 bottles when on spring break when I see you?

Lol ! I've alot of Ergo Goodies choose your pick when ur back in town !

BuckeyeMuscle · 03-13-2008, 11:47 AM

Quote:

Originally Posted by Hypertrophik

Lol ! I've alot of Ergo Goodies choose your pick when ur back in town !

!!!!

I love you! (no homo)

u5711 · 03-13-2008, 12:16 PM

You know... I think this FAQ would be a bit more complete if you would post links to people's logs who ran 11-oxo. I know I would like to see them. Hell, even if you don't want to add them to the FAQ, do you have any links to logs/summaries of people who just ran 11-oxo standalone?

Hypertrophik · 03-13-2008, 12:30 PM

Quote:

Originally Posted by u5711

You know... I think this FAQ would be a bit more complete if you would post links to people's logs who ran 11-oxo. I know I would like to see them. Hell, even if you don't want to add them to the FAQ, do you have any links to logs/summaries of people who just ran 11-oxo standalone?

I will try to find some.