norandrostenedione study

[Patrick Arnold]

i don't think the study intended to be positive but what they reported is

Toxicol Lett. 2008 Feb 2 [Epub ahead of print] Links
The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.Diel P, Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Sch?nzer W, Schleipen B, Thevis M, Vollmer G, Zierau O.
Center for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sports University Cologne, Carl Diem Weg 6, Cologne 50927, Germany.

One of the most frequently misused steroid precursors (prohormones) is 19-norandrostenedione (4-estrene-3,17-dione, NOR), which is, after oral administration, readily metabolised to nortestosterone, also known as nandrolone (durabolin). In this study we have characterised molecular mechanisms of its action determined its tissue specific androgenic and anabolic potency after subcutaneous (s.c.) administration and investigated potential adverse effects. Receptor binding tests demonstrate that NOR binds with high selectivity to the AR. The potency of NOR to transactivate androgen receptor (AR) dependent reporter gene expression was 10 times lower as compared to dihydrotestosterone (DHT). In vivo experiments in orchiectomised rats demonstrated that s.c. treatment with NOR resulted only in a stimulation of the weight of the levator ani muscle; the prostate and seminal vesicle weights remained completely unaffected. Like testosterone, administration of NOR resulted in a stimulation of AR and myostatin mRNA expression in the gastrocnemius muscle. NOR does not affect prostate proliferation, the liver weight and the expression of the tyrosine aminotransferase gene (TAT) in the liver. Summarizing these data it is obvious that NOR, if administrated s.c. and in contrast to its metabolite nandrolone, highly selectively stimulates the growth of the skeletal muscle but has only weak androgenic properties. This observation may have relevance with respect to therapeutic aspects but also doping prevention.

[TheUnlikelyToad]

LOL

Nice new avatar!

[leonidas300]

Have any lying around?

[VaughnTrue]

Have any lying around?

beat me too it

[rpen22]

Nice. Very interesting.

Based on the standard procedure of the Herschberger assay, in this study we have administered NOR and the reference compound TP s.c. in equimolar concentrations of 1 mg/(kg bw). These doses are significantly lower than the doses recommended in the bodybuilder scene for doping purposes (200–300 mg/day, if anabolic steroids are given orally or transdermally, Sinnere and Bachmann, 2004). Nevertheless, TP and NOR both were able to stimulate the weight of the androgen sensitive levator ani muscle in the GDX rats, a clear indication for an anabolic activity. An interesting finding is our observation that, in contrast to TP, NOR has only a low potency to stimulate the growth and weight of typical androgen tissues like the prostate and the seminal vesicle in GDX animals (Fig. 4A and B). Therefore, our tissue weight data clearly characterise NOR to be a pronounced anabolic substance.

[Skigazzi]

Decavol is a 2 step conversion to this target? right?

PA...whats the deal with the "PA Shoveling" pic in the SNAC shirt?

[Hypertrophik]

Good stuff !

[Simon Keller]

Decavol is a 2 step conversion to this target? right?

PA...whats the deal with the "PA Shoveling" pic in the SNAC shirt?

Apparently, when you buy a three month supply of aerobitine, you get a free shirt...

[Skigazzi]

Apparently, when you buy a three month supply of aerobitine, you get a free shirt...

I'd say the chances Pat bought 3 bottles of that are quite slim.

[rpen22]

Decavol is a 2 step conversion to this target? right?

What is Decavol again? 19-Norandrosterone?

Keep in mind that this is referring specifically to subcutaneous admin of Nordione.

[Simon Keller]

I'd say the chances Pat bought 3 bottles of that are quite slim.

So I guess my attempt at humor...FAILED

[Skigazzi]

What is Decavol again? 19-Norandrosterone?

Keep in mind that this is referring specifically to subcutaneous admin of Nordione.

Then I'll just have to mega-dose it...looks like I'll need to take a second mortgage

So I guess my attempt at humor...FAILED

I picked up on it...I just didnt think anyone else would

[rpen22]

Then I'll just have to mega-dose it...looks like I'll need to take a second mortgage

Looks like it's got to be subq for it to work this way. Orally, the majority gets metabolized to Nandrolone on the first pass, which doesn't have the same SARM-like properties.

[Patrick Arnold]

Have any lying around?

no and if i did i wouldn't publically announce it either

[Patrick Arnold]

Decavol is a 2 step conversion to this target? right?

PA...whats the deal with the "PA Shoveling" pic in the SNAC shirt?

decavol converts to nordione in one step

that pic was taken in 2002 when we were breaking ground for our building in champaign

[LCking187]

hey pa when are you gonna announce what is going to be in the new 1 ad

[dmangiarelli]

decavol converts to nordione in one step

that pic was taken in 2002 when we were breaking ground for our building in champaign

I just finished up a cycle with Fast Action Pharma's Trena and I am very impressed with the product. Gained 12+ lbs and people are constantly asking me what I am on. Put an inch on my arms, legs, shoulders and chest. It's good stuff and I'd cycle it again ...

[Patrick Arnold]

I just finished up a cycle with Fast Action Pharma's Trena and I am very impressed with the product. Gained 12+ lbs and people are constantly asking me what I am on. Put an inch on my arms, legs, shoulders and chest. It's good stuff and I'd cycle it again ...

don't hijack the thread

[J2jud]

don't hijack the thread

I dont think DMang is trying to Hijack the thread...

[dmangiarelli]

don't hijack the thread

I was merely posting my results of said 19, norandrostendione I think it's completely 100% relevant ...

Plus I'm older than you so respect your elders ...

[rpen22]

I was merely posting my results of said 19, norandrostendione I think it's completely 100% relevant ...

Plus I'm older than you so respect your elders ...

Trena is not Nordione.

[Patrick Arnold]

I was merely posting my results of said 19, norandrostendione I think it's completely 100% relevant ...

Plus I'm older than you so respect your elders ...

the trena product is not norandrostenedione

so its not relevant at all to the posted abstract.

i will cut you some slack. take your alzheimer medicine next time

[dmangiarelli]

Here is the ingredient list for Trena

19-Norandrosta 4, 9 Diene 3, 17 Dione 10mg

http://www.bodybuilding.com/store/fastaction/trena.html

Isn't that a 19 noradrostenedione? ...

I asked you this before and you said it was

[Patrick Arnold]

Here is the ingredient list for Trena

19-Norandrosta 4, 9 Diene 3, 17 Dione 10mg

http://www.bodybuilding.com/store/fastaction/trena.html

Isn't that a 19 noradrostenedione? ...

I asked you this before and you said it was

thena is a norandrostadienedione, not norandrostenedione

the abstract is specific for norandrostenedione. the extra double bond makes this a different compound with different properties.

[Kernkraft]

no and if i did i wouldn't publically announce it either

touche

Summarizing these data it is obvious that NOR, if administrated s.c. and in contrast to its metabolite nandrolone, highly selectively stimulates the growth of the skeletal muscle but has only weak androgenic properties. This observation may have relevance with respect to therapeutic aspects but also doping prevention.

Good info.

BTW Pat, hopefully that's not a recent pic (the new avatar). If so grow back the beard for God's sakes. Case dismissed.

[nunes]

I thought that nandrolone was a week androgenic also, I believe its more anabolic than test and a lot less androgenic so I`m a bit confuse when they say " and in contrast to its metabolite nandrolone, highly selectively stimulates the growth of the skeletal muscle but has only weak androgenic properties"

[Patrick Arnold]

BTW Pat, hopefully that's not a recent pic (the new avatar). If so grow back the beard for God's sakes. Case dismissed.

that pic is less than two weeks old

ouch

[Patrick Arnold]

I thought that nandrolone was a week androgenic also, I believe its more anabolic than test and a lot less androgenic so I`m a bit confuse when they say " and in contrast to its metabolite nandrolone, highly selectively stimulates the growth of the skeletal muscle but has only weak androgenic properties"

i don't get it either. nordione works as a prohormone to nandrolone and should have negligible intrinsic activity. So it is odd that it would have different pharmacology then nandrolone

an explanation might be that nordione is metabolized to nandrolone less in the sexual organs and more in other parts of the body. that can result in a higher differentiation between anabolic and androgenic effects than even nandrolone

[Hypertrophik]

ouch

Haha !

[nunes]

i don't get it either. nordione works as a prohormone to nandrolone and should have negligible intrinsic activity. So it is odd that it would have different pharmacology then nandrolone

an explanation might be that nordione is metabolized to nandrolone less in the sexual organs and more in other parts of the body. that can result in a higher differentiation between anabolic and androgenic effects than even nandrolone

and for the reading it seems like they say that if a compound has a low androgenic/anabolic ratio its a potential sarm, I never thought things worked that way...


Hey PA, is that resveratrol on your glass?
Here in Portugal we love to take res by glass, lol...