**The Anabolic/Androgenic Dosages & Effects of Formestane**
After receiving numerous PM's about Formestane and proper dosing protocol, I was compelled to create this thread, in which I will outline the proper and effective use of Formestane products.
Formestane(4-Hyroxyandrostenedione) is a steroial aromatase inhibitor and a prohormone to the anabolic steroid 4-Hydroxytestosterone. It is not only effective for estrogen reduction, it is also a mild anabolic steroid. It was first patented by G.D. Searle & Co. in 1955, but it never hit the commercial market. Structurally, 4-Hydroxytestosterone is simply testosterone with a hydroxy group at the four position, making it most similar to the steroid clostebol, which has a chloro group at the four position. Formestane and Clostebol(and Halodrol/Promagnon) are very similar in effect.
4-Hydroxytestosterone is .65 times as anabolic and .25 times as androgenic as testosterone propionate. The reason that Formestane has such low androgenic activity is that the modification at the 4th position prevents DHT conversion. In vitro, 4-Hydroxytestosterone is actually a weak inhibitor of 5-alpha reductase.
Oral Formestane
Estrogen Reduction: 200-500mg
Anabolic/Androgenic effects: 500-1,000mg(*or higher)
Transdermal Formestane
Estrogen Reduction: 100-200mg
Anabolic/Androgenic effects: 300-500mg(*or higher)
Formestane can be used for the following:
-As a stand-alone PROHORMONE in higher dosages.
-While on cycle to reduce estrogen levels while increasing gains.
-As a Testosterone Booster.
*I would not suggest using Formestane during PCT, at this point there is not enough data available to conclude whether or not it will inhibit HPTA recovery.
-Ross Erstling
Owner & CEO of Supreme Sports Enhancements(http://www.bodybuilding.com/store/su...remesports.htm)
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05-16-2009, 09:21 PM #1
**The Anabolic/Androgenic Dosages & Effects of Formestane**
Last edited by TheSupremeBeing; 05-17-2009 at 01:09 AM.
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05-16-2009, 09:22 PM #2
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05-16-2009, 10:34 PM #13
- Join Date: Jan 2007
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What if your adding Formestane to your cycle already and are just looking for the muscle hardness and definition it brings... should you dose it at 200 mg??
"Victory goes to those who make the 2nd to last mistake"
Manlet and Stealing Your White Womminz Crew
Puertorican and Not Mexi Crew
Bangs 7/8's off of POF and OKC Crew
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05-16-2009, 11:33 PM #14
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05-17-2009, 12:38 AM #17
- Join Date: May 2007
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I wouldn't bother with PCT for formestane, regardless of the dose. Only a small amount actually converts to 4-hydroxytestosterone, and I've never seen any evidence pointing to hpta suppression. In fact, everything I've read says suppression does not occur. As far as anabolic effects... meh. This is more of a recomp molecule than anything.
Also... to any company willing (CEL dudes, maybe iForce)... 4-OH-test would be a decent non-methyl designer.
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05-17-2009, 12:42 AM #18
Formestane, in much higer dosages, can indeed become suppressive of natural testosterone production. 4-Hydroxytestosterone is about as anabolic and as androgenic as Clostebol, which is not very suppressive at all, but still requires some form of PCT protocol in order to get testosterone levels OPTIMAL.
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05-17-2009, 12:45 AM #19
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It would make sense that formestane could be suppressive, but from all I've heard/read... it doesn't seem to show any hpta suppression when blood work is done. Again, not saying 4-oh-test isn't suppressive... just pointing out that I don't think any evidence and/or blood work exists showing that formestane can be suppressive. Formestane is probably one of the safest, and most under rated legal supplements out there. It's a shame more quality companies don't put out formestane products... it's DHSEA compliant too.
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05-17-2009, 12:59 AM #20
I agree that Formestane is one of the "safest, and most under rated legal supplements" on the market. I applaud CEL for ressurrecting a transdermal Formestane product.
Formestane has very poor oral bioavailability, so in order to reach high enough blood levels of 4-Hydroxytestosterone that would cause HPTA inhibition, VERY high dosages must be used. However, a transdermal solution makes higher dosing with Formestane a simple reality, and we can easily reach high enough blood levels to induce HPTA inhibition.
Thus, it would require very high dosages in order for oral Formestane to induce HPTA inhibition. However, a transdermal Formestane product only requires 300-500mg to cause HPTA inhibition, as blood levels of 4-Hydroxytestosterone increase.Last edited by TheSupremeBeing; 05-17-2009 at 01:05 AM.
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05-17-2009, 01:05 AM #21
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Eeehhhhh... we'll just agree to disagree on the suppression aspect. lol
Even the research I've seen on intravenously administered formestane shows the primary urinary metabolite being 4-oh-androstenedione, not 4-oh-test. Bio-availability aside, barely any of the stuff converts anyways... which is why I don't particularly worry about hpta suppression. Just my .02 though.
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05-17-2009, 08:40 AM #22
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05-17-2009, 09:38 AM #25
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Id like to see the research for that. I used to think the same thing but have recently changed my mind for lack of actual science to support it. Im not saying the studies may not be out there, Im just saying I havent seen a single study that shows C4 hydroxylation of andro in the food supply.
Matt Cahill
www.DrivenSports.com
www.drivensports.co.uk
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05-17-2009, 09:39 AM #26
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05-17-2009, 10:07 AM #28
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05-17-2009, 11:22 AM #29
- Join Date: May 2007
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Try doing some more research, it most definitely has been released to the commercial market.
Trade name: Lentaron
Ingredients names:
# Formestane
Forms:
# Injectable; Injection; 250 mg
Destination / Category:
# Human
Indications and Usages:
# ATC
# ICD-10
Companies:
# NovartisMatt Cahill
www.DrivenSports.com
www.drivensports.co.uk
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05-17-2009, 11:23 AM #30
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