Derek Beast Charlebois - HMB: Overrated, Overpriced, Or Overlooked: Part 1.

[webmaster]

There is one supplement that pops up in discussions every so often. Today that supplement happens to be HMB. In this article we will examine the current research and science behind HMB to see whether my progress was affected by HMB.

http://www.bodybuilding.com/fun/beast7.htm

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Come on, everyone knows by know that if you calculate how much HMB is necessary to make any real gains, Bill Phillips will be very rich.

There are so many variables in day to day weight, from hydration to whether you have had a **** or not, that to call a gain of one pound a product of HMB is a leap of faith.

[Beast]

Originally Posted by Unregistered

There are so many variables in day to day weight, from hydration to whether you have had a **** or not, that to call a gain of one pound a product of HMB is a leap of faith.

Considering I am a competitive bodybuilder who has had a lot of experience taking bf% with calipers, I did the measurements on the same day each week, at the same time, after using the bathroom, after eating the same meals the entire week, I think my measurements are very accurate.

There is a ton of research showing HMB to decrease protein degradation and muscle loss.

Smith HJ, Wyke SM, Tisdale MJ.
Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate.
Cancer Res. 2004 Dec 1;64(23):8731-5.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15574784

The leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) prevents muscle protein degradation in cancer-induced weight loss through attenuation of the ubiquitin-proteasome proteolytic pathway. To investigate the mechanism of this effect, the action of HMB on protein breakdown and intracellular signaling leading to increased proteasome expression by the tumor factor proteolysis-inducing factor (PIF) has been studied in vitro using murine myotubes as a surrogate model of skeletal muscle. A comparison has been made of the effects of HMB and those of eicosapentaenoic acid (EPA), a known inhibitor of PIF signaling. At a concentration of 50 mumol/L, EPA and HMB completely attenuated PIF-induced protein degradation and induction of the ubiquitin-proteasome proteolytic pathway, as determined by the "chymotrypsin-like" enzyme activity, as well as protein expression of 20S proteasome alpha- and beta-subunits and subunit p42 of the 19S regulator. The primary event in PIF-induced protein degradation is thought to be release of arachidonic acid from membrane phospholipids, and this process was attenuated by EPA, but not HMB, suggesting that HMB might act at another step in the PIF signaling pathway. EPA and HMB at a concentration of 50 mumol/L attenuated PIF-induced activation of protein kinase C and the subsequent degradation of inhibitor kappaBalpha and nuclear accumulation of nuclear factor kappaB. EPA and HMB also attenuated phosphorylation of p42/44 mitogen-activated protein kinase by PIF, thought to be important in PIF-induced proteasome expression. These results suggest that HMB attenuates PIF-induced activation and increased gene expression of the ubiquitin-proteasome proteolytic pathway, reducing protein degradation.


If you are unfamiliar with the ubiquitin-proteasome proteolytic pathway:

Taillandier D, Combaret L, Pouch MN, Samuels SE, Bechet D, Attaix D.
The role of ubiquitin-proteasome-dependent proteolysis in the remodelling of skeletal muscle. Proc Nutr Soc. 2004 May;63(2):357-61. Review.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=15294055

In skeletal muscle, as in any mammalian tissue, protein levels are dictated by relative rates of protein synthesis and breakdown. Recent studies have shown that the ubiquitin-proteasome-dependent proteolytic pathway is mainly responsible for the breakdown of myofibrillar proteins. In this pathway proteins that are to be degraded are first tagged with a polyubiquitin degradation signal. Ubiquitination is performed by the ubiquitin-activating enzyme, ubiquitin-conjugating enzymes and ubiquitin-protein ligases, which are responsible for the recognition of specific substrates. Polyubiquitinated protein substrates are then specifically recognised and degraded by the 26S proteasome. The present review focuses on: (1) the mechanisms of ubiquitination-deubiquitination that make the system highly selective; (2) the mechanisms of proteolysis in skeletal muscle. In particular, the role of the system in the remodelling of skeletal muscle during exercise and disuse and in recovery or regeneration that prevails during post-atrophic conditions is reviewed.

Do you think it could have been due to the placebo effect?

Not criticizing, good article and you clearly know you stuff, just asking.

[str8flexed]

damn you derek! So much for me writing that article. Last time I tell you about what i'm working on over the phone

good job man

[Beast]

Originally Posted by str8flexed

damn you derek! So much for me writing that article. Last time I tell you about what i'm working on over the phone

good job man

I wrote it over a year ago for another site son
I also have a Part II and III done, I just want to edit them a little

[str8flexed]

Originally Posted by Beast

I wrote it over a year ago for another site son
I also have a Part II and III done, I just want to edit them a little

you smug little SOB!

well maybe i'll write a kickass article about the ubiquitin proteasome system that no one will understand lol

[Beast]

Originally Posted by str8flexed

you smug little SOB!

well maybe i'll write a kickass article about the ubiquitin proteasome system that no one will understand lol

I'd like it

[Beast]

Originally Posted by Unregistered

Do you think it could have been due to the placebo effect?

Not criticizing, good article and you clearly know you stuff, just asking.

I do not think it was placebo as gaining lean mass while losing fat (I was hypocaloric) is hard to accomplish. I just started using HMB again last week while doing a UD2 style cut and I am pleased with the results.

Have only done a cursory read....but it appears the series is quite good.

Interesting read. Thanks

[kas]

Hey Derek,

Good job on the articles. You might want to check out a meta-analysis by Nissen et al 2003 that looked at dietary supplements on lean mass and strength gains with resistance exercise. Basically, it reiterates what you concluded, but still worth a glance over.

Ken

[Beast]

Originally Posted by kas

Hey Derek,

Good job on the articles. You might want to check out a meta-analysis by Nissen et al 2003 that looked at dietary supplements on lean mass and strength gains with resistance exercise. Basically, it reiterates what you concluded, but still worth a glance over.

Ken

Thanks Ken. I'll check out the meta-analysis article.