"Upon stimulation of the Ob gene, cellular translation initiates the formation of a leptin precursor protein (Leptin mRNA). This Leptin mRNA is then transcribed into the hormone leptin without any significant post-transcriptional regulation (i.e. most all of the Leptin mRNA ends up becoming Leptin)."
This should read: "Upon stimulation of the Ob gene, cellular transcription initiates the formation of a leptin mRNA (precursor to the leptin protein). This Leptin mRNA is then translated into the hormone leptin without any significant post-transcriptional regulation (i.e. most all of the Leptin mRNA ends up becoming Leptin protein)."
At least, that's how I'd modify it - remember your central dogma of molecular bio, John! DNA-->transcription-->RNA-->translation-->protein. Probably just a typographical error but wouldn't want to confuse any budding biologists
Also, not sure what he was doing when he called an mRNA a "precursor protein" as they are entirely different things, but hopefully he meant that it is a precursor TO a protein so that is how I modified it.
Aside from that, I thought the rest of the article was well written, well organized, and informative, like all the rest of his work that I've read so far. Great recognition that things are never simple when it comes to the complex physiology of the human body, and good presentation of the HBP pathway and its importance. Thanks for the great contribution, John!
Great article; a few corrections
Linear Mode
