ROS and energy expenditure

Par Deus · 05-01-2006, 02:40 PM

J Physiol. 2006 Feb 1;570(Pt 3):629-35. Epub 2005 Nov 24. Related Articles, Links

Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress.

Bell C, Stob NR, Seals DR.

Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. cbell@cahs.colostate.edu

Beta-adrenergic receptor (beta-AR) modulation of resting and postprandial energy expenditure (EE) is augmented in regularly exercising compared with sedentary adults, but the underlying physiological mechanisms are unknown. Differences in thermogenic responsiveness to beta-AR stimulation, perhaps secondary to reactive oxygen species (ROS) bioactivity, may be involved. To determine habitual exercise-related differences in beta-AR thermogenic responsiveness and the possible influence of ROS, we measured the percentage increase in EE (DeltaEE%; indirect calorimetry, ventilated hood method) above resting EE in response to non-specific beta-AR stimulation (intravenous isoproterenol (isoprenaline): 6, 12 and 24 ng (kg fat-free mass)-1 min-1) in 25 sedentary (11 males; 51+/-4 years; body mass index 25.0+/-0.8 kg m-2, maximal oxygen uptake 29+/-1 ml kg-1 min-1 (mean+/-s.e.m.)) and 14 habitually aerobic exercising (9 males, 46+/-6 years, 23.1+/-0.7 kg m-2, 44+/-3 ml kg-1 min-1) healthy adults under normal (control) conditions and during acute intravenous administration of a potent antioxidant, ascorbic acid (vitamin C; 0.04 g (kg fat-free mass)-1). DeltaEE% was greater (P=0.02) in the habitually exercising (8.6+/-1.2, 12.9+/-1.2, 20.0+/-1.4) versus sedentary (6.3+/-0.7, 10.4+/-0.8, 16.0+/-1.0) adults. Ascorbic acid increased (P=0.01) DeltaEE% only in the sedentary adults (to 9.5+/-0.9, 12.4+/-0.7, 18.5+/-0.8), abolishing baseline group differences. DeltaEE% was not related to the amount of body fat, sex, or any other baseline characteristic. Thermogenic responsiveness to beta-AR stimulation is augmented in habitually exercising adults. The mechanism is ascorbic acid dependent, suggesting that it may be linked to decreased ROS bioactivity. Our findings advance a novel mechanism by which habitual physical activity may modulate EE in humans, with potential implications for energy balance and body weight control.

PMID: 16308351 [PubMed - in process]

Discuss amongst yourselves. I may join in, but right now, I am listening to the Stones.

chlaxman · 05-01-2006, 02:44 PM

I know why you're doing this so I will abstain from all of it (both threads) and I have to go to work.

Par Deus · 05-01-2006, 02:52 PM

I'm just trying to get some good science discussion going.

And, if you have some clever ideas about the Stones, I am not afraid to say upfront that I think Mick is WICKED sexy. I am man and mind enough to recognize.

**jkeithc82** · 05-01-2006, 02:54 PM

Quote:

Originally Posted by Par Deus

I'm just trying to get some good science discussion going.

And, if you have some clever ideas about the Stones, I am not afraid to say upfront that I think Mick is WICKED sexy. I am man and mind enough to recognize.

While I will agree to some extent it is humorous, it reeks of the elitism that some other forums have.

Pink Floyd owns the Stones btw.

chlaxman · 05-01-2006, 02:56 PM

Quote:

Originally Posted by Par Deus

I'm just trying to get some good science discussion going.

And, if you have some clever ideas about the Stones, I am not afraid to say upfront that I think Mick is WICKED sexy. I am man and mind enough to recognize.

That's a lie. I don't care really, but it is a lie.

...the first part anyways.

Kledz · 05-01-2006, 03:00 PM

Quote:

Originally Posted by Par Deus

And, if you have some clever ideas about the Stones, I am not afraid to say upfront that I think Mick is WICKED sexy. I am man and mind enough to recognize.

http://www.cnn.com/2006/SHOWBIZ/Musi....ap/index.html

Discuss...

Par Deus · 05-01-2006, 03:10 PM

Quote:

Originally Posted by jkeithc82

While I will agree to some extent it is humorous, it reeks of the elitism that some other forums have.

Power to the Prols!!!!!!!!

Par Deus · 05-01-2006, 03:12 PM

Quote:

Originally Posted by jkeithc82

Pink Floyd owns the Stones btw.

And, BTW, I don't need your education or thought control.

Plenty of both here.

Power to the Prols!!!!!!!

BOO-YAH!!!!!!!!

**jkeithc82** · 05-01-2006, 03:15 PM

Quote:

Originally Posted by Par Deus

And, BTW, I don't need your education or thought control.

You sure do Caleb.

Dito likes the new Roger Waters cd. I haven't had a chance to listen yet.

Par Deus · 05-01-2006, 03:15 PM

Quote:

Originally Posted by Kledz

http://www.cnn.com/2006/SHOWBIZ/Musi....ap/index.html

Discuss...

If I'm climbing Palm trees in foreign lands and taking care of business with 20 year olds in 35 years, then..... well, my misanthropy is clearly misplaced.

DejaBlue55 · 05-01-2006, 03:18 PM

You ont want that

Kledz · 05-01-2006, 03:25 PM

Quote:

Originally Posted by Par Deus

If I'm climbing Palm trees in foreign lands and taking care of business with 20 year olds in 35 years, then..... well, my misanthropy is clearly misplaced.

Time will tell... until then keep it right where it is.

Kledz · 05-01-2006, 03:30 PM

Quote:

Originally Posted by jkeithc82

Dito likes the new Roger Waters cd. I haven't had a chance to listen yet.

I havent heard it either, hes on tour also. Apparently he'll be playing DS in its entirety, which is quite enticing.

Par Deus · 05-01-2006, 03:50 PM

Quote:

Originally Posted by Kledz

Time will tell... until then keep it right where it is.

Are you threatening me???

My TP won't like it.

Blap Blaow · 05-01-2006, 04:11 PM

better get my vit C then I suppose.

dito · 05-01-2006, 04:17 PM

Quote:

Originally Posted by jkeithc82

You sure do Caleb.

Dito likes the new Roger Waters cd. I haven't had a chance to listen yet.

It's David Gilmour, twat! Waters new album is an opera Ca Ira.

Skigazzi · 05-01-2006, 04:18 PM

Quote:

Originally Posted by Blap Blaow

better get my vit C then I suppose.

Well, yea, only if you are sedentary......and breathing I suppose.

**jkeithc82** · 05-01-2006, 04:26 PM

Quote:

Originally Posted by dito

It's David Gilmour, twat! Waters new album is an opera Ca Ira.

Oh right right. I must have been high on acid again.

Blap Blaow · 05-01-2006, 04:26 PM

Quote:

Originally Posted by Skigazzi

Well, yea, only if you are sedentary......and breathing I suppose.

I get lazy at cardio time

Par Deus · 05-01-2006, 04:49 PM

No discussion of the original topic??

The findings of that paper are terribly important for anyone who wants to be lean and healthy beyond 30.

Or, beyond 10, if you are a big fat person.

Twin Peak · 05-01-2006, 04:55 PM

Quote:

Originally Posted by Par Deus

No discussion of the original topic??

The findings of that paper are terribly important for anyone who wants to be lean and healthy beyond 30.

Or, beyond 10, if you are a big fat person.

Moral of the story -- exercise more.

G.W. Hayduke · 05-01-2006, 05:08 PM

Quote:

Originally Posted by jkeithc82

Dito likes the new Roger Waters cd. I haven't had a chance to listen yet.

It's crap. It's Roger Waters with no fire whatsoever. It's as if he's trying to imitate the ghost of himself. (but isn't this album somewhat old?)

BTW, new Tool album coming out tomorrow!

chlaxman · 05-01-2006, 05:14 PM

Quote:

Originally Posted by Aeternitatis

It's crap. It's Roger Waters with no fire whatsoever. It's as if he's trying to imitate the ghost of himself. (but isn't this album somewhat old?)

BTW, new Tool album coming out tomorrow!

And the new Red Hot Chili Peppers. I'll get the Tool album first I think.

DejaBlue55 · 05-01-2006, 05:17 PM

Quote:

Originally Posted by chlaxman

And the new Red Hot Chili Peppers. I'll get the Tool album first I think.

Going to RHCP and OAR this summer

Kledz · 05-01-2006, 10:34 PM

Quote:

Originally Posted by Par Deus

No discussion of the original topic??

Cmon, you're a smart guy... you know the strawman fallacy.

Par Deus · 05-14-2006, 04:12 PM

Still no actual discussion of the science......

BringnIt · 05-14-2006, 04:59 PM

So basically they intravenously gave a non-specific beta adrenergic receptor agonist and measured energy expenditure in trained and sedentary individuals. The trained group had a greater increase in EE than the untrained, so we can make the conclusion that exercise increases the body's efficiency at utilizing fat stores. Both groups were given vitamin C but only the sedentary group experienced an increase in EE from it, likely due to the fact that habitual exercise increases the production of the body's natural antioxidant defenses such as glutathione. Ergo, excessive free radical production without ample antioxidant production hinders fat loss, and according to other studies probably hinders recuperation after exercise.

Moral of the story, exercise on a regular basis and take your antioxidants.

BringnIt · 05-14-2006, 05:05 PM

Also, not sure how they determined the mechanism was ascorbic acid dependant as there was no group deficient in ascorbic acid. They just showed probably cause that ROS was detrimental to beta receptor stimulated lypolisis. Unless I missed something.

BringnIt · 05-14-2006, 05:06 PM

Is this some kind of subliminal message to make me buy Muscle-Tech's CREAKIC?

Par Deus · 05-14-2006, 05:29 PM

Quote:

Originally Posted by BringnIt

So basically they intravenously gave a non-specific beta adrenergic receptor agonist and measured energy expenditure in trained and sedentary individuals. The trained group had a greater increase in EE than the untrained, so we can make the conclusion that exercise increases the body's efficiency at utilizing fat stores. Both groups were given vitamin C but only the sedentary group experienced an increase in EE from it, likely due to the fact that habitual exercise increases the production of the body's natural antioxidant defenses such as glutathione. Ergo, excessive free radical production without ample antioxidant production hinders fat loss, and according to other studies probably hinders recuperation after exercise.

Moral of the story, exercise on a regular basis and take your antioxidants.

Yep.