methylation of roids...

[growthismygoal]

I want to increase my knowledge and understanding of several areas of interest relating to PH/PS/AAS. Before anyone even asks I will state that I am not planning on using any of these anytime soon. I am a couple months shy of 20y.o. and have done enough research to know not to mess with that sh*t yet. However, I am very interested in messing with that sh*t in several years, but I want to be VERY knowledgable before doing so. My questions:

1) What is the process of "methylation"? What happens to the original steroid/PH that changes it into a methylated compound?

2) Why are methylated compounds more heptatoxic than non-methylated ones?

3) Why even methylate if it increases liver toxicity? (I assume that this somehow makes the roid more effective?)

If anyone can provide answers to these questions it would be very appreciated. If anyone can provide me with advice on another, more in-depth and comprehensive source of info on this (and other general info relating to PH/PS/AAS) it would be even more appreciated. I know that alot of people on these boards know their sh*t but I also know that alot of people think they know when in reality they are just regurgitating some useless info they read that someone else posted. I would really love to study this stuff comprehensively so if anyone could advise on good sources of info for that it would be really cool. I have decent understanding of biology and chemistry (majoring in biochemistry) so I can read fairly advanced stuff. Thanks.

[Blast_]

Someone correct me if I am wrong.

1. Methylation is the addition of a methyl group (-CH3). In a steroid/PH case, the methylation is at the 17α carbon.

2. Since the compound is methylated, it will not be broken down by the liver. This, in turn, increases liver enzymes because the liver tries to break it down.

3. Because the liver will metabolize it, rendering the compound useless.

[growthismygoal]

Originally Posted by Blast_

Someone correct me if I am wrong.

1. Methylation is the addition of a methyl group (-CH3). In a steroid/PH case, the methylation is at the 17? carbon.

2. Since the compound is methylated, it will not be broken down by the liver. This, in turn, increases liver enzymes because the liver tries to break it down.

3. Because the liver will metabolize it, rendering the compound useless.

1. Sounds consistent with what else I have read.
2. I might be way off here, but is what your saying that the steroid is NOT metabolized by the liver, and therefore the enzymes that the liver produced (to metabolize the roid) actually metabolize the liver? The liver cannabolizes itself?
3. Then how are nonmethylated compounds (Orastan-A, etc.) so successful?

[Drumkid20]

If you want the indepth low down, PM me. I'll try and clear things up.

[1987GN]

Originally Posted by Drumkid20

If you want the indepth low down, PM me. I'll try and clear things up.

could you shoot me a copy of that pm? I love to learn about this stuff as much as possible.

thanks.