LG Sciences Ghenerate - NO WE WON'T TELL YOU THE INGREDIENTS..well maybe

[ZB126]

Originally Posted by Imeniaan

so, where the ingredients @ ?

on the way i bet

[UNCnate]

Originally Posted by ZB126

on the way i bet

That was yesterday

[ZB126]

Originally Posted by UNCnate

That was yesterday

still on the way? :P

[CraigMatthew]

Originally Posted by Imeniaan

so, where the ingredients @ ?

Originally Posted by UNCnate

That was yesterday

Originally Posted by ZB126

still on the way? :P

The fans are waiting Eric :P

[JBerto]

Originally Posted by legalgear

I will release the write up tomorrow. We will then put up a pre-order combo on the site for people and should have stock late next week.

bump

[legalgear]

Sorry man, got horribly sick this weekend. Will get it up tonight!

[FameGirl]

Originally Posted by legalgear

Sorry man, got horribly sick this weekend. Will get it up tonight!

Feel better, Eric! I hate this time of year for that reason.

[Imeniaan]

Originally Posted by legalgear

Sorry man, got horribly sick this weekend. Will get it up tonight!

get well soon bro!

[legalgear]

Why the world needs a GREAT GH supplement!

My parents are getting a little on in years and growth hormone replacement therapy is all the rage right now. I wanted to help get my parents a great GH product that worked. Sadly, I didn't see my mom injecting herself every day in order to look younger. I had read about GHRP-2 and GHRP-6 and I was intrigued. They show great promise in the literature! Unfortunately, these two peptide hormones are sold as injectables. I thought that maybe I could try them under the tongue to get penetration and to my pleasant surprise, there was some serious potential there. I was certainly not going to give her some homeopathic "GH" or deer velvet which I knew didn't work and quite frankly pissed me off.

I started looking heavily into growth hormone release and I saw that there are two main pathways. The first I've discussed, which is the GHRP pathway or the Growth Hormone Secretagogue receptor. This is stimulated by Ghrelin and GHRP-6/GHRP-2. This pathway is very potent at releasing GH and is a good route, yet there are more potent routes of growth hormone release which is why we needed a two phase technology to get the job done.

Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic. So, I started looking in the literature for NATURAL versions of GHRP to use. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2). This was an amazing find, I could now legally sell a supplement that had the same effect as GHRP-2 without being illegal! Understand, that this peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor! Amazing find but I couldn't stop there.

GHRH is the other receptor that allows for LARGE increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. Luckily, we found an amazing GHRH stimulating supplement that I included in GHenerate to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph will detail what GHRH agonist I found!

Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!

These two ultra potent pathways are what give GHenerate the amazing body recomp, appetite increasing effects that were experienced by our testers and make it the most potent GH secreting agent ever produced. One tester gained 8lbs on GHenerate alone, which is unheard of for a GH product. There is nothing on the market like GHenerate!

What about IGH-1? Luckily IGH-1, our GH secretagogue works in a totally different manner, which is to reduce somatostatin, meaning it will enhance and increase the potential of GHenerate. Somatostatin is the natural hormone your body produces to reduce GH production, so blocking this is a very good thing to do with GHenerate.

Reference Studies:
1) Horm Metab Res. 2004 Feb;36(2):86-91. Induction of growth hormone release by Pueraria thunbergiana BENTH. Jung DY, Ha H, Kim C. Drug Research and Development Team, Korea Institute of Oriental Medicine, 129-11 Chungdam-dong, Kangnam-ku, Seoul 135-100, Korea.

Puerariae Radix (PR), Puerariae Flos (PF), and Puerariae Surculus (PS) as well as their constituents were tested for induction of rat growth hormone (rGH) release by both rat pituitary cell culture and in vivo experimentation in order to develop them to novel drugs. Through a calibration curve of the rGH released by addition of rat growth hormone-releasing hormone (rGHRH) to rat pituitary cells, the 70 % ethanol extracts of PR and PS increased rGH release by about 1.6 and 1.7 times as high, respectively, as the control group (264.6 +/- 13.6 pM). However, each puerarin type as a representative constituent of PR in Korea Pharmacopeia (KP) and tectorigenin and an important ingredient of PF were twice as effective as in the control group. The acid hydrolysate of Puerariae Surculus (HPS) increased rGH release concentration-dependently, and its EC (50) was approximately 10.4 microg/ml. The T (max) value for rGH after injection of 20 microg/kg of rGHRH was 10 - 30 min, while the C (max) value was increased by approximately 12-fold compared to the control group (198.2 +/- 25.0 pM) and the AUC (0 - 45) was increased to 10 times the level of the control group (10,840.9 +/- 845.5 min. pM). On the other hand, T (max) for the HPS was 60 min, while C (max) was increased approximately to 5.8 fold compared to control (244.1 +/- 36.4 pM). C (max) for puerarin was 1,028.6 +/- 502.7 pM, that is, approximately 5.2 times as high as the control level. However, tectorigenin (20 microg/kg) was of no statistical significance. Therefore, we suggest that the HPS and puerarin act either on GH secretagogue receptors or on GHRH receptor of somatotrophin as possible agonists or an inhibitor on somatostatin receptor to release rGH, respectively.

2) Peptides. 2006 Jul;27(7):1597-602. Epub 2006 Feb 17. Ghrelin in plants: what is the function of an appetite hormone in plants? Aydin S Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

In the present work, we provide compelling evidence for the expression of a ghrelin-like peptide hormone that has only been associated with animals, in various plant tissues. Ghrelin, the appetite stimulating hormone, has been identified from a number of different species including humans, rat, pig, mouse, gerbil, eel, goldfish, bullfrog and chicken. The study here was conducted using an immunohistochemistry assay to screen whether plants have any ghrelin immunoreactivity. In this respect, Prunus x domestica L. and Marus alba were examined. Immunohistochemistry results showed that there is a strong human ghrelin immunoreactivity substance in the parenchyma cells of these plants. This was entirely unexpected since this hormone was considered to be present solely in animals. Thus, this study is the first to report the presence of a peptide with ghrelin-like activity in plants, a finding that has only been observed in the animal kingdom. RIA analysis confirmed that these plants contain significant amounts of this substance. Furthermore, reverse-phase HPLC analyses of plant extracts showed an elution characteristic of the peptide identical to that of human ghrelin. In general, fruit from both plants had higher levels of the peptide than the vegetative parts.

3) Food Chem Toxicol. 2008 Dec;46(12):3671-6. Epub 2008 Sep 23. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Li Y, Chen H, Yang S, Xie G. Cancer Hospital of Tianjin, Tianjin Medical University, Ti-Yuan-Bei, Tianjin 330060, China. liyanwei127@hotmail.com

4) Toxicol Appl Pharmacol. 2008 Dec 15;233(3):371-81. Epub 2008 Sep 19. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Hwang YP, Jeong HG.

[CraigMatthew]

Wooo and so it is released!

[antbanks]

now we're getting somewhere. very interesting stuff!

[JBerto]

Interesting!

[Hwdstrn]

Originally Posted by legalgear

Why the world needs a GREAT GH supplement!

My parents are getting a little on in years and growth hormone replacement therapy is all the rage right now. I wanted to help get my parents a great GH product that worked. Sadly, I didn't see my mom injecting herself every day in order to look younger. I had read about GHRP-2 and GHRP-6 and I was intrigued. They show great promise in the literature! Unfortunately, these two peptide hormones are sold as injectables. I thought that maybe I could try them under the tongue to get penetration and to my pleasant surprise, there was some serious potential there. I was certainly not going to give her some homeopathic "GH" or deer velvet which I knew didn't work and quite frankly pissed me off.

I started looking heavily into growth hormone release and I saw that there are two main pathways. The first I've discussed, which is the GHRP pathway or the Growth Hormone Secretagogue receptor. This is stimulated by Ghrelin and GHRP-6/GHRP-2. This pathway is very potent at releasing GH and is a good route, yet there are more potent routes of growth hormone release which is why we needed a two phase technology to get the job done.

Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic. So, I started looking in the literature for NATURAL versions of GHRP to use. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2). This was an amazing find, I could now legally sell a supplement that had the same effect as GHRP-2 without being illegal! Understand, that this peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor! Amazing find but I couldn't stop there.

GHRH is the other receptor that allows for LARGE increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. Luckily, we found an amazing GHRH stimulating supplement that I included in GHenerate to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph will detail what GHRH agonist I found!

Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by IGF-1 and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!

These two ultra potent pathways are what give GHenerate the amazing body recomp, appetite increasing effects that were experienced by our testers and make it the most potent GH secreting agent ever produced. One tester gained 8lbs on GHenerate alone, which is unheard of for a GH product. There is nothing on the market like GHenerate!

What about IGH-1? Luckily IGH-1, our GH secretagogue works in a totally different manner, which is to reduce somatostatin, meaning it will enhance and increase the potential of GHenerate. Somatostatin is the natural hormone your body produces to reduce GH production, so blocking this is a very good thing to do with GHenerate.

Reference Studies:
1) Horm Metab Res. 2004 Feb;36(2):86-91. Induction of growth hormone release by Pueraria thunbergiana BENTH. Jung DY, Ha H, Kim C. Drug Research and Development Team, Korea Institute of Oriental Medicine, 129-11 Chungdam-dong, Kangnam-ku, Seoul 135-100, Korea.

Puerariae Radix (PR), Puerariae Flos (PF), and Puerariae Surculus (PS) as well as their constituents were tested for induction of rat growth hormone (rGH) release by both rat pituitary cell culture and in vivo experimentation in order to develop them to novel drugs. Through a calibration curve of the rGH released by addition of rat growth hormone-releasing hormone (rGHRH) to rat pituitary cells, the 70 % ethanol extracts of PR and PS increased rGH release by about 1.6 and 1.7 times as high, respectively, as the control group (264.6 +/- 13.6 pM). However, each puerarin type as a representative constituent of PR in Korea Pharmacopeia (KP) and tectorigenin and an important ingredient of PF were twice as effective as in the control group. The acid hydrolysate of Puerariae Surculus (HPS) increased rGH release concentration-dependently, and its EC (50) was approximately 10.4 microg/ml. The T (max) value for rGH after injection of 20 microg/kg of rGHRH was 10 - 30 min, while the C (max) value was increased by approximately 12-fold compared to the control group (198.2 +/- 25.0 pM) and the AUC (0 - 45) was increased to 10 times the level of the control group (10,840.9 +/- 845.5 min. pM). On the other hand, T (max) for the HPS was 60 min, while C (max) was increased approximately to 5.8 fold compared to control (244.1 +/- 36.4 pM). C (max) for puerarin was 1,028.6 +/- 502.7 pM, that is, approximately 5.2 times as high as the control level. However, tectorigenin (20 microg/kg) was of no statistical significance. Therefore, we suggest that the HPS and puerarin act either on GH secretagogue receptors or on GHRH receptor of somatotrophin as possible agonists or an inhibitor on somatostatin receptor to release rGH, respectively.

2) Peptides. 2006 Jul;27(7):1597-602. Epub 2006 Feb 17. Ghrelin in plants: what is the function of an appetite hormone in plants? Aydin S Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

In the present work, we provide compelling evidence for the expression of a ghrelin-like peptide hormone that has only been associated with animals, in various plant tissues. Ghrelin, the appetite stimulating hormone, has been identified from a number of different species including humans, rat, pig, mouse, gerbil, eel, goldfish, bullfrog and chicken. The study here was conducted using an immunohistochemistry assay to screen whether plants have any ghrelin immunoreactivity. In this respect, Prunus x domestica L. and Marus alba were examined. Immunohistochemistry results showed that there is a strong human ghrelin immunoreactivity substance in the parenchyma cells of these plants. This was entirely unexpected since this hormone was considered to be present solely in animals. Thus, this study is the first to report the presence of a peptide with ghrelin-like activity in plants, a finding that has only been observed in the animal kingdom. RIA analysis confirmed that these plants contain significant amounts of this substance. Furthermore, reverse-phase HPLC analyses of plant extracts showed an elution characteristic of the peptide identical to that of human ghrelin. In general, fruit from both plants had higher levels of the peptide than the vegetative parts.

3) Food Chem Toxicol. 2008 Dec;46(12):3671-6. Epub 2008 Sep 23. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Li Y, Chen H, Yang S, Xie G. Cancer Hospital of Tianjin, Tianjin Medical University, Ti-Yuan-Bei, Tianjin 330060, China. liyanwei127@hotmail.com

4) Toxicol Appl Pharmacol. 2008 Dec 15;233(3):371-81. Epub 2008 Sep 19. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Hwang YP, Jeong HG.

I said it had something to do with ghrelin early in this thread. Your formulation sounds interesting.

[daytonaMuscle]

i'm ready to get my hands on this!

[The Bavarian]

This holds a lot of promise. Great work legalgear!







Bring it on the market NOW!!!
(and please make sure that it will be available over here in Europe)

[CraigMatthew]

Originally Posted by antbanks

now we're getting somewhere. very interesting stuff!

Yup, very interesting product! Unique for sure and so far logs are looking insanely good. We have another 7 logs running right now. So in 3 weeks we will have 14+ logs to consider.

Originally Posted by JBerto

Interesting!

Originally Posted by Hwdstrn

I said it had something to do with ghrelin early in this thread. Your formulation sounds interesting.

Yeah weren't far off man, interesting indeed!

Originally Posted by daytonaMuscle

i'm ready to get my hands on this!

Same here man! Mine should be on the way now! wooohoo

[CraigMatthew]

Originally Posted by The Bavarian

This holds a lot of promise. Great work legalgear!







Bring it on the market NOW!!!
(and please make sure that it will be available over here in Europe)

There will be pre-sales VERY soon! Looks like it will be sold by itself and also in a combo type deal with IGH-1, which Eric theorises will greatly increase the results of this product.

[nosaj03]

When is this expected to be in stores?

[FameGirl]

Very cool eric!

[legalgear]

Thank you, I thought so!

[CraigMatthew]

Originally Posted by nosaj03

When is this expected to be in stores?

Pre sale up now on our homepage

[PortendingEnnui]

ordered 2, thanks for the heads up!

[bassinyoface]

sounds like a cool product!!!

[svtfocusmansvt]

Originally Posted by CraigMatthew

Pre sale up now on our homepage

I am about to order off of your site. I have a couple of questions to make sure I get the best gains. Ghenerate comes with a free bottle of I-Gh-1, what is the best way to take these two products together to achieve the best gains? And also I am about up on my stack of Creadex, N.O. Plasmacore, and Anabolic O.D., I did not receive a large amount of gains from the M.A.P products (although I may have lacked on the protein diet which I am experimenting on now to help out.) What stack do you recommend to go with the 'Ghenerate and I-Gh-1? My stats are I am 5' 6", 154 lbs and cant seem to build a large amount of muscle mass. I have only been into heavily training for around 3 months I will give it time and hopefully in the next cycle or two I can start to see some heavy gains. Thanks in advance for the input! The Trifecta Stack deal with the free T-911 seems to be a good stack any other supplements recommended with this stack such as creatine?

[CraigMatthew]

Originally Posted by PortendingEnnui

ordered 2, thanks for the heads up!

No worries man! Let us know how you like it!

Originally Posted by bassinyoface

sounds like a cool product!!!

Pre sale on now man! Get in there!

Originally Posted by svtfocusmansvt

I am about to order off of your site. I have a couple of questions to make sure I get the best gains. Ghenerate comes with a free bottle of I-Gh-1, what is the best way to take these two products together to achieve the best gains? And also I am about up on my stack of Creadex, N.O. Plasmacore, and Anabolic O.D., I did not receive a large amount of gains from the M.A.P products (although I may have lacked on the protein diet which I am experimenting on now to help out.) What stack do you recommend to go with the 'Ghenerate and I-Gh-1? My stats are I am 5' 6", 154 lbs and cant seem to build a large amount of muscle mass. I have only been into heavily training for around 3 months I will give it time and hopefully in the next cycle or two I can start to see some heavy gains. Thanks in advance for the input! The Trifecta Stack deal with the free T-911 seems to be a good stack any other supplements recommended with this stack such as creatine?

Take GHenerate 6 sprays, 2x daily. Pre workout and pre bed. The igh-1, take the capsules at night on a emoty stomach.

[ericpad]

Pre-order placed. Excited to try this stuff.

Any idea when it'll ship? Also, will this stack well with a test booster like t-911 or TestoPro?

[biggkarim]

awesome

[legalgear]

Should ship next week

[ZB126]

Originally Posted by legalgear

Should ship next week

Sweet!

[CraigMatthew]

Originally Posted by ericpad

Pre-order placed. Excited to try this stuff.

Any idea when it'll ship? Also, will this stack well with a test booster like t-911 or TestoPro?

As Lg said next week for shipping.
With stacking, running thsi with a test booster could be awesome! We have not had any testers run it with anything else yet, as we wanted it to be run solo. The pontential stacking ability of this product is awesome!

Originally Posted by ZB126

Sweet!

saaaweeeet!!! How many did you order man?