Creatine

[kiker15]

I know once when you get off creatine you lose your gains. Does fish oil prevent breakdown after you get off creatine? I there anyway to preserve the hard earned muscle after creatine use has stopped?? I read in countless articles that fish oil does prevent muscle breakdown and promotes muscle growth.

[b18cyaaa]

You will lose the water weight you gained on creatine. However, you should keep some of the size and all the strength you gained while taking creatine.

[Adjusting]

You don't suddenly go catabolic when you cycle off creatine. You'll lose intracellular water weight. No biggie really, you'll still have made some permanent gains from creatine.

I'm not aware of fish oil being anti-catabolic in healthy HUMANS. If you have cancer however it shows massive promise. Then again, anyone will hugely benefit in every aspect of their life when they supplement omega 3's when they're deficient.

Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.Whitehouse AS, Tisdale MJ.
Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom.

A number of acute wasting conditions are associated with an upregulation of the ubiquitin-proteasome system in skeletal muscle. Eicosapentaenoic acid (EPA) is effective in attenuating the increased protein catabolism in muscle in cancer cachexia, possibly due to inhibition of 15-hydroxyeicosatetraenoic acid (15-HETE) formation. To determine if a similar pathway is involved in other catabolic conditions, the effect of EPA on muscle protein degradation and activation of the ubiquitin-proteasome pathway has been determined during acute fasting in mice. When compared with a vehicle control group (olive oil) there was a significant decrease in proteolysis of the soleus muscles of mice treated with EPA after starvation for 24 h, together with an attenuation of the proteasome "chymotryptic-like" enzyme activity and the induction of the expression of the 20S proteasome alpha-subunits, the 19S regulator and p42, an ATPase subunit of the 19S regulator in gastrocnemius muscle, and the ubiquitin-conjugating enzyme E2(14k). The effect was not shown with the related (n-3) fatty acid docosahexaenoic acid (DHA) or with linoleic acid. However, 2,3,5-trimethyl-6-(3-pyridylmethyl)1,4-benzoquinone (CV-6504), an inhibitor of 5-, 12- and 15-lipoxygenases also attenuated muscle protein catabolism, proteasome "chymotryptic-like" enzyme activity and expression of proteasome 20S alpha-subunits in soleus muscles from acute fasted mice. These results suggest that protein catabolism in starvation and cancer cachexia is mediated through a common pathway, which is inhibited by EPA and is likely to involve a lipoxygenase metabolite as a signal transducer. Copyright 2001 Academic Press.

[warrior504th]

Originally Posted by kiker15

I know once when you get off creatine you lose your gains. Does fish oil prevent breakdown after you get off creatine? I there anyway to preserve the hard earned muscle after creatine use has stopped?? I read in countless articles that fish oil does prevent muscle breakdown and promotes muscle growth.

It prevents muscle breakdown and promotes growth, but not as some sort of protection against creatine.

Creatine is completely safe, and by the end of a cycle (cycling only to increase effectiveness, not because of some health issue), coming off of it will only really cause a loss of water weight. If you keep working as hard as you always have, you should lose no strength or muscle.

so technically you lose 'size', but it's all water, and you should be thankful for the increased definition on your offcycle anyway.