NO-XPLODE: side effects?

[drey]

Hey
i just started using NO, and its great i love it. I've been hearing some things about the side effects lately. I searched the internet but they are all very vague, and it hasnt been long enough to determine the long-term side effects as of yet. My buddy has been telling me that because its harsh on ur liver, its really (REALLY) bad to have alcohol at any point of your NO-workout period. Anyone know if thats a roumor or how serious that really is? Also, if anyone has experienced something else wierd with this stuff, let me know.
Thanks,
drey

[Husker]

its pretty harsh on my butthole to be honest with....stuff gives me mud butt. besides that i dont kow any side effects

[burlybig]

I second the mud butt statement. Its the truth

[Yogurt]

I can't sleep while taking it. Either it is just a coincidence or it is the NO-XPLODE.

[Husker]

what time do u take it at?

[DaEagles4Life]

I would say the biggest side effect for me is my body seems to get use the product over time and you have to either cycle the product or increase the load every so often

[deserusan]

All the rage lately has been about NO2 products. I have done some research on the efficacy of hemodilators in bodybuilding and have found them to be unsafe for long term use. Here's a good summary I have found on the web. The sources cited are of merit so anyone reading this should take it seriously.

"Nitric oxide supplements are the hottest thing on the market. Athletes are buying them in droves without knowing exactly what is happening in the body. Supplement companies claim to educate their consumers with pamphlets and informational websites, but these only offer an incomplete story of what is actually happening. Manufacturers state that nitric oxide supplements, via the compound arginine alpha-ketoglutarate, gives the athlete added energy, mental focus, workout intensity, perpetual pump and muscle growth. Upon closer investigation, these effects are largely exaggerated and in some cases completely fallacious. While arginine is involved in the regulation of growth hormone release, the supplemental dosages that would stimulate a noticeable effect are astronomical. Arginine is also a substrate for nitric oxide; an effect that is enhanced when combined with alpha-ketoglutarate. Nitric oxide is released by the walls of the blood vessels that cause a decrease in the resistance and an increase in blood flow to the skeletal muscles. Arginine may also stimulate the release of epinephrine from the adrenal gland. These two effects are mostly beneficial to endurance athletes, not strength athletes like the manufacturers suggest. Grasemann et al. (2005) determined that participants receiving as little as 200 mg of L-arginine showed a significant increase in nitric oxide formation, as well as significant increases in plasma L-arginine and sputum L-arginine. This indicates that L-arginine supplementation does indeed induce nitric oxide formation. Rytlewski et al. (2005) found that three weeks of L-arginine supplementation lead to significant drops in systolic blood pressure, diastolic blood pressure, and mean arteriole pressure while elevating urinary excretion of NOx (nitrates) and mean plasma levels of l-citrulline. However, plasma L-arginine levels were not effected even with 300 mg of supplementation. Thusfar it has been established that L-arginine supplementation does indeed stimulate nitric oxide synthesis. Now it must be addressed whether or not this is beneficial to athletes.

Paddon-Jones et al. (2004) found that nitric oxide supplementation does not provide an ergogenic effect to healthy individuals. Miguez et al. (2004) found that 4 weeks of L-arginine supplementation increased serum triglyceride levels and significantly increased levels of low-density lipoprotein (LD) cholesterol. This is obviously cause for concern and needs to be further investigated. Evans et al. (2004) sought to find the optimal dosage of L-arginine to elicit the greatest effect on nitric oxide synthesis. Manufacturers recommend upwards of 6000-10000 mg/day but many athletes report taking even higher dosages as much as 35000 mg/day, nearly six times the recommended intake. Evans (2004) found that half the participants supplementing with 20000 mg/day reported serious adverse side effects from L-arginine supplementation and over half of the participants reported severe side effects when taking more than 20000 mg/day. A significant portion of individuals supplementing with 9000 mg/day reported adverse effects, and over the duration of the supplementation period, no participants experienced any sort of weight gain. Chu et al. (2004) found that L-arginine supplementation impaired pulmonary endothelium-dependent relaxation of vascular tissue. This may lead to potentially dangerous vascular spasms and cardiovascular abnormalities.

It has been found that L-arginine keto-gluterate supplementation stimulates rapid vasidilation in a non-discriminatory fashion. Significant vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, significant drop in both systolic and diastolic blood pressure. During exercise, it is imperative that diastolic blood pressure remain constant. It is natural for systolic blood pressure to rise during the onset of exercise, but diastolic blood pressure values must remain constant. A drop in either during exercise is cause for great concern and can lead to serious cardiovascular damage. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels leading to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to a vascular catastrophe.

Based on the available research, this author strongly recommends that athletes avoid nitric oxide and hemodilator supplements in the interest of safety. Moreover, it has been suggested that these supplements have little or no anabolic or ergogenic benefits for the athlete."

To be honest, I have tried a few arginine alpha-ketoglutarate products out their and have found that they do little for strength or size gains. If you eat a well balanced bodybuilding diet you can acheive the same "pump" effect.

[drey]

wow deserusan, thats sounds pretty serious, thanks a lot for the heads up

[peggx312]

Thanks for the information. I am currently using No-Xplode and it seems to be doing the trick, however I am not using any other NO products and the only side effects that I have been getting are what everyone else in this thread has reported :Mud Butt. But I can tolerate that.

[Hekk]

I started taking cell-mass and no-xplode for the first week and was fine. On my second week I started experiencing dizziness and headaches. I am going to continue taking cellmass but I am going to lay off the no-xplode.

[kungpow108]

ya, i get a slight crash from no-xplode if I don't keep up with my water and food intake perfectly. but lucky for me I have never really gotten "mud butt" from it. the product really volumizes my muscles and gets me putting out more reps and weight. for the pump, it doesn't help me too much but then again I never can seem to get big veins to show

[netiad]

i haven't had any side effects. other than building a tolerance for it.

these are what i hear others have had.

"Butt-Hole Xplode" lol, that's my favorite.

some say they got head aches but stopped getting them after they increased how much water they drank.

personally i want to try white flood but i'm not to keen on the coco bean extract they have in it.

[akim9]

Originally Posted by burlybig

I second the mud butt statement. Its the truth

3rd it

[double t33]

Originally Posted by deserusan

All the rage lately has been about NO2 products. I have done some research on the efficacy of hemodilators in bodybuilding and have found them to be unsafe for long term use. Here's a good summary I have found on the web. The sources cited are of merit so anyone reading this should take it seriously.

"Nitric oxide supplements are the hottest thing on the market. Athletes are buying them in droves without knowing exactly what is happening in the body. Supplement companies claim to educate their consumers with pamphlets and informational websites, but these only offer an incomplete story of what is actually happening. Manufacturers state that nitric oxide supplements, via the compound arginine alpha-ketoglutarate, gives the athlete added energy, mental focus, workout intensity, perpetual pump and muscle growth. Upon closer investigation, these effects are largely exaggerated and in some cases completely fallacious. While arginine is involved in the regulation of growth hormone release, the supplemental dosages that would stimulate a noticeable effect are astronomical. Arginine is also a substrate for nitric oxide; an effect that is enhanced when combined with alpha-ketoglutarate. Nitric oxide is released by the walls of the blood vessels that cause a decrease in the resistance and an increase in blood flow to the skeletal muscles. Arginine may also stimulate the release of epinephrine from the adrenal gland. These two effects are mostly beneficial to endurance athletes, not strength athletes like the manufacturers suggest. Grasemann et al. (2005) determined that participants receiving as little as 200 mg of L-arginine showed a significant increase in nitric oxide formation, as well as significant increases in plasma L-arginine and sputum L-arginine. This indicates that L-arginine supplementation does indeed induce nitric oxide formation. Rytlewski et al. (2005) found that three weeks of L-arginine supplementation lead to significant drops in systolic blood pressure, diastolic blood pressure, and mean arteriole pressure while elevating urinary excretion of NOx (nitrates) and mean plasma levels of l-citrulline. However, plasma L-arginine levels were not effected even with 300 mg of supplementation. Thusfar it has been established that L-arginine supplementation does indeed stimulate nitric oxide synthesis. Now it must be addressed whether or not this is beneficial to athletes.

Paddon-Jones et al. (2004) found that nitric oxide supplementation does not provide an ergogenic effect to healthy individuals. Miguez et al. (2004) found that 4 weeks of L-arginine supplementation increased serum triglyceride levels and significantly increased levels of low-density lipoprotein (LD) cholesterol. This is obviously cause for concern and needs to be further investigated. Evans et al. (2004) sought to find the optimal dosage of L-arginine to elicit the greatest effect on nitric oxide synthesis. Manufacturers recommend upwards of 6000-10000 mg/day but many athletes report taking even higher dosages as much as 35000 mg/day, nearly six times the recommended intake. Evans (2004) found that half the participants supplementing with 20000 mg/day reported serious adverse side effects from L-arginine supplementation and over half of the participants reported severe side effects when taking more than 20000 mg/day. A significant portion of individuals supplementing with 9000 mg/day reported adverse effects, and over the duration of the supplementation period, no participants experienced any sort of weight gain. Chu et al. (2004) found that L-arginine supplementation impaired pulmonary endothelium-dependent relaxation of vascular tissue. This may lead to potentially dangerous vascular spasms and cardiovascular abnormalities.

It has been found that L-arginine keto-gluterate supplementation stimulates rapid vasidilation in a non-discriminatory fashion. Significant vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, significant drop in both systolic and diastolic blood pressure. During exercise, it is imperative that diastolic blood pressure remain constant. It is natural for systolic blood pressure to rise during the onset of exercise, but diastolic blood pressure values must remain constant. A drop in either during exercise is cause for great concern and can lead to serious cardiovascular damage. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels leading to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to a vascular catastrophe.

Based on the available research, this author strongly recommends that athletes avoid nitric oxide and hemodilator supplements in the interest of safety. Moreover, it has been suggested that these supplements have little or no anabolic or ergogenic benefits for the athlete."

To be honest, I have tried a few arginine alpha-ketoglutarate products out their and have found that they do little for strength or size gains. If you eat a well balanced bodybuilding diet you can acheive the same "pump" effect.

didnt expect to see that from a rep! if you are a rep... normally they would be in here saying BUY OUR NO2 beats all the others hands down

good advice.

[netiad]

actually its seems like sometimes after coming off of no xplode i get a little depressed. not bad just feeling a little down.

also i thought it was the milk since i'm lactose intolerant but i haven't drank milk in a while and i still get diarrhea after my workout. the only thing that is the same is the fact that i take no xplode.

if i were you i would search the forum for something that you don't get a tolerance for.

i hear superpump, aka "superdump" is even worse as far as the poops go. i hear sometimes you have to pause in your workout to go take a duke. but that could be just rumors. i've never tried it.

[adriandaigle]

I've been using NO Xplode since I started working out in '06. I love it and have never found any negative side effects. I do take occasional breaks from the product, but I'm always glad to get back on. I can def see the difference in my workouts when I don't take it.

Adrian

[mdizzle109]

i broke out in a full body rash/hives because of this stuff. that was in addition to the mudbutt.

i tried a different NO and no rash but still mudbutt.

also, my heart was pounding through my chest at all times. not the best feeling in the world. i stay far away from NO products.

[dmc1122]

I concur with the mudd butt. Sometimes early in the morning, ten minutes after taking it, I'll get the ****ts! Also, I have found that it puts me into a very focused kind of mood where I don't want to socialize at all. I'd say these are the two negative side effects I have come across. It's decent stuff, but I've stoppped using it and haven't looked back.

[joem4077]

I, too, suffer from this "Mud Butt" that everyone is speaking of.

I never took the 4 week break after 12 weeks of use like it says to do on the jar, so I'm currently paying the price for it. I have no energy and no appetite. It's tough to hold food down. Consuming alcohol is darn near impossible.

I don't think I'm going to resume taking it after the 4 weeks are up.

[whey_chubby]

Never got the mud butt. I've tried a few different NO supps and xplode seems to agree with me the most. No side effects and it does help out with my energy levels & endurance. I've increased the weight I'm lifting pretty rapidly since using xplode. I have heard of similar mud butt stories with superpump though.

[Jandonian]

hyperthyroidism.


Sucks.