Transreveratrol Raises Serum Testosterone Levels!

[dmangiarelli]

1: Arch Pharm Res. 2008 Jan;31(1):83-7.Links
trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.Shin S, Jeon JH, Park D, Jang MJ, Choi JH, Choi BH, Joo SS, Nahm SS, Kim JC, Kim YB.
College of Veterinary Medicine, Chungbuk National University, Heungdeok-gu, Cheongju, Chungbuk 361-763, Korea.

We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5x10(-5) M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/ kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.

PMID: 18277612 [PubMed - in process]

Discuss ...

[DaveGabe24]

This product continues to look better and better man, AI really hit the jackpot. Great job you guys.

[NO HYPE]

Resveratrol is some good stuff. Many benefits.

[warugaki]

wheres Dinoiii?

[DaveGabe24]

Originally Posted by NO HYPE

Resveratrol is some good stuff. Many benefits.

Yeah, really catching my interest.

[dmangiarelli]

Originally Posted by slyc

wheres Dinoiii?

I'll email this to him ...

[warugaki]

Originally Posted by dmangiarelli

I'll email this to him ...

yeah i believe he commented on this study before...perhaps at leanbulk...

[dmangiarelli]

Originally Posted by slyc

yeah i believe he commented on this study before...perhaps at leanbulk...

I'll have to look it up over there ...

[user903890348904]

if u had 50% bulk, what would be a staple amount to take daily?

[sonicology]

Not meaning to steal your thunder, but I think PA created a thread about this study a few weeks ago:

http://forum.bodybuilding.com/showthread.php?t=7512541

Doesn't hurt to let more people see it however, I believe resveratrol is one of if not the most exciting compounds in the supplement market today.

[u5711]

I was just gonna say, where is PA... lol.


This stuff is still inhibitively expensive though considering the amount you need IMO.

[UNCfan1]

Damng I posted this study at LB in Dinoiii's section after PA posted it. He responded there. I can post it here if needed.

Good post regardless though.

[dmangiarelli]

Originally Posted by sonicology

Not meaning to steal your thunder, but I think PA created a thread about this study a few weeks ago:

http://forum.bodybuilding.com/showthread.php?t=7512541

Doesn't hurt to let more people see it however, I believe resveratrol is one of if not the most exciting compounds in the supplement market today.

Nothing like rehashing a good study!

[Peter LeDrew]

I think resveratrol has potential... Even if doesn't pan out in bodybuilding circles, it goes far beyond the superficial.

I recommend and use Acta-Resveratrol by AOR. I used a Biotest formula but gave me the ****s as it was only a 50% trans-res and likely contained more emodin... a natural laxative.

This is the best Res. I have found anywhere. http://www.aor.ca/int/products/acta_resveratrol.php

100mg pure Trans-Res in oxygen, light and pH-resistant beadlets.
20 Luteolin (antioxidant and improves absorption)
51mg Quercetin (Anti-ox/improves absorption)
40mg Vitamin C
20mg Piper Nigrum (Improves absorption)

The formula works in synergy to improve absorption and benefits of Res so lower doses can be taken.

The latest dosing suggestions I have read suggest 100-300mg as being optimum for benefit to safety. Some say higher, but it is still new so personally taken regularly I would not go over 300mg at my bodyweight.

I haven't used PC Support by AI but it looks like a good product and many seem to like it.

[dmangiarelli]

This was dinoii's remarks on LB

Did anyone happen to see the use of 50mg/kg which translates into 4545mg (4.5 grams) for a 200-pound human WITHOUT dose-adjustment upward, which translates into a much higher volume-of-distribution estimate for a human anyway (which is something we knew and NO supplement has that kind of concentration)?

Not to mention, the pre-contraction with phenylephrine. The study is worthless for extrapolative purposes.

[dmangiarelli]

Originally Posted by Peter LeDrew

I think resveratrol has potential... Even if doesn't pan out in bodybuilding circles, it goes far beyond the superficial.

I recommend and use Acta-Resveratrol by AOR. I used a Biotest formula but gave me the ****s as it was only a 50% trans-res and likely contained more emodin... a natural laxative.

This is the best Res. I have found anywhere. http://www.aor.ca/int/products/acta_resveratrol.php

100mg pure Trans-Res in oxygen, light and pH-resistant beadlets.
20 Luteolin (antioxidant and improves absorption)
51mg Quercetin (Anti-ox/improves absorption)
40mg Vitamin C
20mg Piper Nigrum (Improves absorption)

The formula works in synergy to improve absorption and benefits of Res so lower doses can be taken.

The latest dosing suggestions I have read suggest 100-300mg as being optimum for benefit to safety. Some say higher, but it is still new so personally taken regularly I would not go over 300mg at my bodyweight.

I haven't used PC Support by AI but it looks like a good product and many seem to like it.

I am logging a PCT with it right now with blood work so we'll see how it fares for that purpose!

[scrag]

Sounds good but the study is not on humans.

[Peter LeDrew]

Originally Posted by dmangiarelli

I am logging a PCT with it right now with blood work so we'll see how it fares for that purpose!

interested!

[Vanilla Thunder]

Originally Posted by Peter LeDrew

I
The formula works in synergy to improve absorption and benefits of Res so lower doses can be taken.

The latest dosing suggestions I have read suggest 100-300mg as being optimum for benefit to safety. Some say higher, but it is still new so personally taken regularly I would not go over 300mg at my bodyweight.

I haven't used PC Support by AI but it looks like a good product and many seem to like it.

I take 1.5-2 grams / day of Giant Reveratrol.

Have been since it came out, whenever that was.

[DaveGabe24]

Originally Posted by Vanilla Thunder

I take 1.5-2 grams / day of Giant Reveratrol.

Have been since it came out, whenever that was.

What's your experience been like?

[dmangiarelli]

Originally Posted by scrag

Sounds good but the study is not on humans.

LOL! I am sure there will be human studies but they ALWAYS start on animals ...

[Vanilla Thunder]

Originally Posted by DaveGabe24

What's your experience been like?

I dunno really. I think I'm supposed to live longer. Check back with me in 60 years and see if I'm still kickin'.

[NO HYPE]

Originally Posted by sonicology

I believe resveratrol is one of if not the most exciting compounds in the supplement market today.

I agree (shameless plug = can't wait for T-BOL).

[pittbleauxs]

Would this be a good way to take resveratrol?

http://www.bodybuilding.com/store/no...sveratrol.html

Dosed sufficiently etc?

[NO HYPE]

Originally Posted by Peter LeDrew

The latest dosing suggestions I have read suggest 100-300mg as being optimum for benefit to safety. Some say higher, but it is still new so personally taken regularly I would not go over 300mg at my bodyweight.

Peter, I am curious as to where those latest suggestions on resveratrol dosing originate from?

The only reason I ask is due to the fact that in-vivo rodent studies have concluded that doses of 300 mg per kg/bw show no detrimental effects in rats, and doses up to 100 mg per kg/bw have been used routinely in studies on rodents.

Crowell et al. Resveratrol-associated renal toxicity. Toxicol. Sci. 82, 614?619 (2004).

[Peter LeDrew]

Originally Posted by NO HYPE

Peter, I am curious as to where those latest suggestions on resveratrol dosing originate from?

The only reason I ask is due to the fact that in-vivo rodent studies have concluded that doses of 300 mg per kg/bw show no detrimental effects in rats, and doses up to 100 mg per kg/bw have been used routinely in studies on rodents.

Crowell et al. Resveratrol-associated renal toxicity. Toxicol. Sci. 82, 614?619 (2004).

Maybe out of my ass!! lol, I'll see if I can find it now...
http://www.lef.org/magazine/mag2008/...eratrol_01.htm

The fine folks at lef broke down much of the research and if you look at the 3rd page, three paragraphs from the bottom you will see...

There remains the intriguing possibility, however, that far higher doses of resveratrol might produce better anti-aging benefits. As a result, dedicated Life Extension members have been increasing their resveratrol intake to 100-300 mg a day and higher.

Now I don't know how the hell I remembered that? I just seem to have a good memory when it comes to this stuff... guess I am interested in it.

So I think they talk about the potential for even higher dosing, but then go on to say...
While we cannot recommend that aging people exceed 250-400 mg of resveratrol daily, we also cannot argue with the logic of seeking the potential longevity benefits that may be associated with higher-dose resveratrol supplementation.

I guess if you are so inclined you may want to go higher, especially if you are older and looking for that anti-aging effect.
Regarding a serm effect or raising test, I don't think anyone knows what the goal dosing would be.

Always remember even low dosing 20-100mg should confer some benefit to most, especially in combination with other synergistic compounds..ie. grapeseed ext.
The table at the bottom of the pg.3 is also interesting.

If you have an effective, reliable and well absorped product such as the one I use then I think dosing would not need to be as high. So that is something else to keep in mind.

[darknessWithin]

0.4 grams a day will do almost nothing

[Vanilla Thunder]

I'm pretty sure it's supposed to be dosed around 1.5-2 grams / day.

[armondscipione]

Here is a 250mg full spectrum trans-resveratrol.

http://www.bodybuilding.com/store/le...sveratrol.html

[Patrick Arnold]

Originally Posted by Peter LeDrew

I think resveratrol has potential... Even if doesn't pan out in bodybuilding circles, it goes far beyond the superficial.

I recommend and use Acta-Resveratrol by AOR. I used a Biotest formula but gave me the ****s as it was only a 50% trans-res and likely contained more emodin... a natural laxative.

This is the best Res. I have found anywhere. http://www.aor.ca/int/products/acta_resveratrol.php

100mg pure Trans-Res in oxygen, light and pH-resistant beadlets.
20 Luteolin (antioxidant and improves absorption)
51mg Quercetin (Anti-ox/improves absorption)
40mg Vitamin C
20mg Piper Nigrum (Improves absorption)

The formula works in synergy to improve absorption and benefits of Res so lower doses can be taken.

The latest dosing suggestions I have read suggest 100-300mg as being optimum for benefit to safety. Some say higher, but it is still new so personally taken regularly I would not go over 300mg at my bodyweight.

I haven't used PC Support by AI but it looks like a good product and many seem to like it.

a company called relentless improvement sells a 98% resveratrol with 300mg per cap