Sclareolides: The secret behind SAN Tight ?

[pu12en12g]

I hadn't noticed until just recently, that Sclareolides (Clary Sage Extract) is the 4th main ingredient. Could this explain why so many people are hooked on this stuff ?

Sclareolides is a diterpenoidal lactone found in a plant called Salvia sclarea. Sclareolides is known to be an extremely potent adenylate cyclase activator, very similar to that of the diterpene derivative, forskolin. In fact, cyclic AMP assays indicate Sclareolides either equals or exceeds the actions of forskolin, but with a much longer active life. Like forskolin, Sclareolides stimulates adenylate cyclase independently of beta-2 receptors, which means it has no limitations because it won't down-regulate and it has a higher maximal effect. In other words, the more you take, the greater the effect day after day after day. Sclareolides mimics or acts like TSH activating adenylate cyclase in the membrane of thyroid cells, which in turn elevates cyclic AMP and eventually leads to thyroid hormones being released. Sclareolides may also enhance the cyclic AMP response to TSH in thyroid cells as well. Because Sclareolides produce an accumulation of cyclic AMP, it will also increase nitrogen retention. This means that it will help preserve or even build lean-body mass (muscle) while increasing lipolysis. Sclareolides doesn't interact with beta-1 adrenoreceptors and over stimulate cardiac tissue or raise blood pressure. In fact, Sclareolides, in very high doses, exhibit a vasodilatory effect and slightly decreases blood pressure. Other benefits of Sclareolides include antithrombotic and antidepressant effects, as well as its stimulating effect on luteinizing hormone, via cyclic AMP, resulting in the production of additional Testosterone (in males).

The King of Cyclic AMP

Sclareolides are a diterpenoidal lactone found in a plant called Salvia sclarea. It's known to be an extremely potent adenylate cyclase activator, very similar to that of the diterpene derivative, forskolin. In fact, cyclic AMP assays indicate Sclareolides either equals or exceeds the actions of forskolin, but with a much longer active life.

Additionally, like forskolin. Sclareolides stimulates adenylate cyclase independently of beta-2 receptors, which means it has no limitations because it won't down-regulate and it has a higher maximal effect. In other words, the more you take, the greater the effect--day after day after day ... So Sclareolides essentially mimics or acts like TSH--activating adenylate cyclase in the membrane of thyroid cells, which in turn elevates cyclic AMP and eventually leads to thyroid hormones being released. It may also enhance the cyclic AMP response to TSH in thyroid cells as well.

And because Sclareolides produces an accumulation of cyclic AMP, it will also increase nitrogen retention. This means that it will help preserve or even build lean-body mass (muscle) while increasing lipolysis.

Another huge bonus in comparison to ephedra and other beta agonists is that Sclareolides doesn't interact with beta-1 adrenoreceptors and over stimulate cardiac tissue or raise blood pressure. In fact, Sclareolides, in very high doses, exhibits a vasodilatory effect and slightly decreases blood pressure.

Some other benefits of Sclareolides include its antithrombotic and antidepressant effects, as well as its stimulating effect on luteinizing hormone, via cyclic AMP, resulting in the production of additional Testosterone (in males).

To synergize the effects of Sclareolides, we included the methylxanthine caffeine. Caffeine is a potent competitive inhibitor of phosphodiesterase enzyme, which is responsible for the inactivation of cyclic AMP.

In comparison to caffeine, Sclareolides increases the formation of cyclic AMP, whereas caffeine acts to prevent its degradation. In other words, caffeine potentiates the effects of Sclareolides, thus increasing the magnitude of cyclic AMP accumulation.

And since Sclareolides and caffeine increase cyclic AMP, but via different mechanisms and not through the beta receptor, a combination produces a powerful, synergistic effect on lipolysis.

So you can see that, even though A7-E, Sclareolides, guggulsterones, and caffeine have discrete roles in the fat-loss process, they also potentiate one another's activities, making the combination extremely powerful.

[bigpump23]

it may be, but from posts I read more people are dissapointed in Tight then pleased with it

[pu12en12g]

it may be, but from posts I read more people are dissapointed in Tight then pleased with it

The typical review I have heard is "This stuff is powerful ****", "1/2 dosage worked for me".. etc.. etc.. which started to make me wonder what the hell ? (Because overall, the ingredients aren't exactly mind-blowing)

16 positive reviews
7 negative

[bigpump23]

hey i remember for like 2 weeks straight reading post that Tight sucked and no one felt it. I tried it myself and same thing, nothing

[Matt96teg]

It works well if you stack it with some ephedra

[Lonny]

It works well if you stack it with some ephedra

I was thinking about doing this on my next cut. i loved Coleus in my MM4 last year stacked with ephedrine. The other stuff doesn't interest me too much.

[j_neatherlin]

i tried Tight! when it first came out...and I know that they've changed the formula a time or three since then. I didn't like it. Were Sclareolides in the old formula?

[sowle2themax]

taking it right now with ephedrine and think tight works great
have loads of energy throughout the day