CONTROLLED LABS - Blue GENE FAQ (Frequently Asked Questions)

[pu12en12g]

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance (attached)

changes in markers of mitochondrial biogenesis were associated with an increase in both maximal endurance capacity (P < 0.05) and voluntary wheel-running activity (P < 0.05). These benefits of querectin on fitness without exercise training may have important implications for enhancement of athletic and military performance and may also extend to prevention and/or treatment of chronic diseases.

[pu12en12g]

Effects of Quercetin and EGCG on Mitochondrial Biogenesis and Immunity

[pu12en12g]

These data support in vitro observations that quercetin supplements may reduce illness rates after periods of heavy training by athletes through direct antipathogenic mechanisms.

http://www.ncbi.nlm.nih.gov/pubmed/17805089

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[pu12en12g]

Arnold School study reveals benefits of quercetin

Quercetin may not be a household word -- yet.

But a study by researchers at the University of South Carolina’s Arnold School of Public Health shows that the powerful antioxidant/anti-inflammatory compound found in fruits and vegetables significantly boosts endurance capacity and maximal oxygen capacity (VO2max) in healthy, active but untrained men and women.

The findings of the study – one of the first in humans to examine the energy-boosting effects of quercetin – are reported in the International Journal of Sports Nutrition and Exercise Metabolism, published online Wednesday (June 24).

Dr. Mark Davis, the study’s lead author and a professor of exercise science, said the fatigue-fighting and health properties of quercetin – found in the skins of red apples, red onions, berries and grapes – have implications not only for athletes and soldiers whose energy and performance are tested to the extreme, but also for average adults who battle fatigue and stress daily.

“The natural, biological properties of quercetin that include powerful antioxidant and anti-imflammatory activity, as well as the ability to boost the immune system and increase mitochondria (the powerhouse of the cell) in muscle and brain is great news for those who often think that they’re too tired to exercise,” Davis said.

“While there’s no magic pill to make people get up and move, or to take the place of regular exercise, quercetin may be important in relieving the fatigue that keeps them sedentary and in providing some of the benefits of exercise,” he said. “We believe that this could be a major breakthrough in nutrition.”

For the study, funded in part by the U.S. Department of Defense, 12 participants were randomly assigned to one of two treatments. Half were given 500 milligrams of quercetin twice a day in Tang for seven days. The other subjects drank Tang with placebos. After the seven days of treatment, during which the subjects were told not to alter their physical activity, the participants rode stationary bicycles to the point of fatigue.

Researchers also tested their additional VO2max, one of the most important measures of fitness. Then the participants received the opposite treatment for another seven days before riding the bicycle to the point of fatigue and VO2max tests. Neither the participants nor the research staff knew who received the quercetin Tang or the placebo Tang, and all subjects took part in the quercetin and placebo treatments.

“The participants were healthy, relatively active, college-age students, but they were not physically trained athletes, and they were not taking part in a regular exercise training program,” he said.

The results: After taking quercetin for only seven days, the participants had a 13.2 percent increase in endurance and a 3.9 percent increase in VO2max.

“These were statistically significant effects that indicate an important improvement in endurance capacity in a very short time,” Davis said. “Quercetin supplementation was able to mimic some of the effects of exercise training.

Although the study did not examine why the results were so dramatic, Davis said pre-clinical data suggest that quercetin may increase the mitochondria in brain and muscle cells. He likened the mitochondria to the “powerhouse of the cell,” producing most of its energy. Mitochondria in brain and muscle also are believed to be fundamentally important in battling age-related dementia, obesity, diabetes and cardiovascular dysfunction.

“One of the most important biological mechanisms for increasing endurance is increasing the mitochondria,” said Davis. “More mitochondria in the brain and muscle would enhance both mental and physical energy, as well as provide a better ability to fight other diseases in which mitochondrial dysfunction are hallmarks.”

Quercetin also appears to have valuable properties to fight inflammation, which has been linked to health problems such as colon cancer and heart disease. Davis’ research group has recently received a National Institutes of Health grant to study quercetin’s effects on colon cancer and others are pending that involve breast cancer.

“If the findings of this study and others on the biological mechanisms of quercetin are confirmed in future clinical studies, the implications go beyond improvements in endurance,” he said. “We may find that quercetin may work in conjunction with regular physical activity as an ally in preventing and treating diabetes, obesity and cardiovascular diseases and the degenerative diseases of aging.”

[pu12en12g]

Quercetin treatment actually resulted in prolonged and increased total synthesis of HSP70 protein.

The symptoms of the alcohol hangover are largely due to the activation of inflammation. An extract of the OFI plant has a moderate effect on reducing hangover symptoms, apparently by inhibiting the production of inflammatory mediators

Quercetin reduces susceptibility to influenza infection following stressful exercise

In conclusion, this is the first controlled experimental study to show a benefit of short-term quercetin feedings on susceptibility to respiratory infection following exercise stress. Quercetin feeding was an effective preventive strategy to offset the increase in susceptibility to infection (morbidity, symptom severity, and mortality) that was associated with stressful exercise. If our data can be clinically translated, they may lead to an important nutritional strategy to decrease the risk of infection, which can be a problem in athletes and military personnel, who are often exposed to combinations of severe physical, psychological, and environmental stress.

..... MUCH more to come, thanks to our customers for making Blue GENE the #13 ranked Muscle Builder on BB.COM !!!

[cervasa1977]

looks like my alumni are on the same page as us on this

[Dracoy]

Great post Pt!

[CONTROLLED LABS]

Blue Gene is very much ahead of its time which is testament by all of the fairly recent research

[whey greek]

I'm currently vacationing at my summer home overseas and I have brought supplements with me to continue my workout regimen. I don't have the a ton of weights but I do my best.

I will be here for an additional 14 days and am running out of Blue Gene... my question is, should I continue to take Blue Gene as normal till it runs out (5 pills daily) or spread out the pills to last the full 10 days (less dosage: 4 on workout days and 3 on non workout days)?

[pu12en12g]

I'm currently vacationing at my summer home overseas and I have brought supplements with me to continue my workout regimen. I don't have the a ton of weights but I do my best.

I will be here for an additional 14 days and am running out of Blue Gene... my question is, should I continue to take Blue Gene as normal till it runs out (5 pills daily) or spread out the pills to last the full 10 days (less dosage: 4 on workout days and 3 on non workout days)?

Do you have more at your other home when you get back, or what's the plan ?

[whey greek]

Do you have more at your other home when you get back, or what's the plan ?

Yes, once I get back I plan on stocking up again. I'm not sure if the 4-3 combination would be pointless. I did this towards the end of my Green Bulge bottle because I thought I could minimize the weight loss once I got off Green Bulge by extending the amount of days I took it... even at a lesser dosage. My weight has fluctuated since then.

Does the improper dosage negate any potential effect?

[pu12en12g]

In that short term scenario, save the tabs for gym days.

[whey greek]

In that short term scenario, save the tabs for gym days.

Will do, thanks for the advice.

[violencenz]

Question related to the one above, I am not looking for this product's "maximum" effect (just yet). Are there any negatives to using only 3 or so pills/day over my 3-4 gym days?
Thanks

[pu12en12g]

Question related to the one above, I am not looking for this product's "maximum" effect (just yet). Are there any negatives to using only 3 or so pills/day over my 3-4 gym days?
Thanks

Not really, but can you give us more detail ?

[CONTROLLED LABS]

Question related to the one above, I am not looking for this product's "maximum" effect (just yet). Are there any negatives to using only 3 or so pills/day over my 3-4 gym days?
Thanks

why wouldnt you want the results? I dont get it

[violencenz]

Results are nice, but I'm not looking to get enormous

[CONTROLLED LABS]

Results are nice, but I'm not looking to get enormous

the full dose will be fine

[Marshall28]

Ok so I have 3 bottles of blue gene in hand. Should I run it for 60 days and then take a break and then run the last bottle?

Thanks!

[bull.dogz]

Ok so I have 3 bottles of blue gene in hand. Should I run it for 60 days and then take a break and then run the last bottle?

Thanks!

I haven't cycled mine yet.

[CONTROLLED LABS]

Ok so I have 3 bottles of blue gene in hand. Should I run it for 60 days and then take a break and then run the last bottle?

Thanks!

there really is no need to cycle, at least in the short term, it would be optional to do so

[Marshall28]

Perfect! Thanks for the responses.

[pu12en12g]

Perfect! Thanks for the responses.

Can't wait for your feedback ! The word is SLOWLY starting to get out about this formula !!

[Marshall28]

2 Weeks into my bulk. I have noticed an increased pump and my body seems to be recovering faster than before. Still to early to say strength has increased but I have put weight on and overall feeling better.

[CONTROLLED LABS]

2 Weeks into my bulk. I have noticed an increased pump and my body seems to be recovering faster than before. Still to early to say strength has increased but I have put weight on and overall feeling better.

awesome, its starting to take effect nicely in that case. do you have any joint issues at all coming in to this?

[lauhpurush]

blue gene is working wonders for me ....no sore muscles, increased stamina and remarkable strength....

my lifting stats have increased like anything during the past few weeks..

i was a bit apprehensive before buying it for the first time, but after seeing the awesome results, i guess its gonna become my staple supplement

[RyKane]

With the PH ban I foresee more people trying BG :-). I enjoyed my time while on it and saw great results.

[CONTROLLED LABS]

blue gene is working wonders for me ....no sore muscles, increased stamina and remarkable strength....

my lifting stats have increased like anything during the past few weeks..

i was a bit apprehensive before buying it for the first time, but after seeing the awesome results, i guess its gonna become my staple supplement

awesome to hear, most people are hesitant, but once they use it, they understand why its a staple in many people's regiments

With the PH ban I foresee more people trying BG :-). I enjoyed my time while on it and saw great results.

absolutely, maybe people will stop killing their major organs for a change and use an product that will help with gains AND health

[pu12en12g]

absolutely, maybe people will stop killing their major organs for a change and use an product that will help with gains AND health

****ing WERD !!!111

[palanilopez12]

I haven't cycled mine yet.

so cycling isn't necessary for this product? how about after 90 days? would it still be safe to continue taking the product without taking a bit of time off...the only reason I'm asking is because it says take product for 60 days then take 2 weeks off