NCOR-1: Want to be 2x as strong and have more endurance!

Sounds like every product on this site...

[url]http://www.ncbi.nlm.nih.gov/pubmed/22078881[/url]

From Gizmag:

He can't fly just yet, but a team of scientists have made a big step towards creating a real-life Mighty Mouse. Researchers at the Salk Institute for Biological Studies, along with two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the University of Lausanne, created a batch of super-strong mice and worms by tweaking a gene that normally inhibits muscle growth.

The scientists acted on a genome regulator - known as NCOR1 - and were able to change the activity of certain genes. In simpler English, the scientists shut off the thyroid hormone that keeps most mammals from turning into the Incredible Hulk. The result was a strain of mice with muscles that were twice as strong as normal.





Besides nearly bringing the world's second most popular cartoon mouse to life (Mickey comes in at number one) and making the premise of the film Tremors seem slightly more feasible, the findings could help in the creation of new treatments for muscle degeneration.

"This could be used to combat muscle weakness in the elderly, which leads to falls and contributes to hospitalizations," Johan Auwerx, the lead author from EPFL says. "In addition, we think that this could be used as a basis for developing a treatment for genetic muscular dystrophy."

Gain without the pain

The research could also yield more good news for the epidemic of obesity that plagues many western countries.

"There are now ways to develop drugs for people who are unable to exercise due to obesity or other health complications, such as diabetes, immobility and frailty," says Ronald M. Evans, who led the Salk team. "We can now engineer specific gene networks in muscle to give the benefits of exercise to sedentary mice."

Auwerx describes molecules such as NCOR1 as "molecular brakes" that slow down the activity in genes. Releasing these brakes through gene manipulation increases that activity level, providing more energy to build muscle.

The benefits of releasing those molecular brakes don't stop at increased muscle strength. The stronger mice also saw improved endurance, and were capable of running both faster and longer before tiring, covering twice the distance of normal mice in experiments. Researchers say the mutated mice were also more tolerant to cold.

Going after the genetic inhibitor is the inverse of previous approaches that involved "genetic accelerators." Researchers believe that because the method proved successful in both mice and worms, then the same techniques could be applied to a wide range of species.

Interesting, but it's nothing new. Look up Follistatin (myostatin inhibitor). I think it was expensive as hell and hard to come by.

[QUOTE=stratoo;799565611]Interesting, but it's nothing new. Look up Follistatin (myostatin inhibitor). I think it was expensive as hell and hard to come by.[/QUOTE]

It is new and it is not a myostatin inhibitor.

It looks like the study is new, but the NCOR-1/TRAC-1 protein and the NCOR-1 gene are not.

Results may have been new as well.

Check out the wiki page on NCOR-1 and you'll see that the research goes back to 1994, at least.

It looks like the discovery/isolation of the NCOR-1/TRAC-1 protein or perhaps the suppression of the protein have been in studies since 2005.

That aside, it's another one that looks good for genetic mods and muscle building therapy.

Myostatin/Follistatin treatment is reputed to have 3x growth as untreated, so combine the two and you have 6x the muscle building power, right?

Not srs about the combo, but Myostatin Inhibition seems to have a bit more of a profound effect on muscle mass (3x vs 2x).

[QUOTE=RMBros;799653881]It looks like the study is new, but the NCOR-1/TRAC-1 protein and the NCOR-1 gene are not.

Results may have been new as well.

Check out the wiki page on NCOR-1 and you'll see that the research goes back to 1994, at least.

It looks like the discovery/isolation of the NCOR-1/TRAC-1 protein or perhaps the suppression of the protein have been in studies since 2005.

That aside, it's another one that looks good for genetic mods and muscle building therapy.

Myostatin/Follistatin treatment is reputed to have 3x growth as untreated, so combine the two and you have 6x the muscle building power, right?

Not srs about the combo, but Myostatin Inhibition seems to have a bit more of a profound effect on muscle mass (3x vs 2x).[/QUOTE]

What will be interesting is if/when human trials begin what the WADA will do. Even if the best they manage is 2x strength that would put most of us above the current wr levels. It would be pretty lame to watch the olympics and see guys lifting weights you are clearing in training every day just because they are required to abide by WADA policy.

[QUOTE=Iberian80;800049391]What will be interesting is if/when human trials begin what the WADA will do. Even if the best they manage is 2x strength that would put most of us above the current wr levels. It would be pretty lame to watch the olympics and see guys lifting weights you are clearing in training every day just because they are required to abide by WADA policy.[/QUOTE]
The big thing will be testing - genetic mods are a ton harder to check for from what I gather.

Because some of these mods occur naturally, it would seem that you would have to get some sort of baseline for an athlete established way before they became elite/competitive and measure against that.

Are the gene suppressors/inhibitors like on/off switches - once you take them the gene stays suppressed - or do you have to continue to take them?

If you can simply take one for a while, then quit taking it, but retain your muscle mass (and possibly type) gains - there is going to be no way to test for these and no reason not to take them.

The big problem with AASs and most other PEDs is that the majority of the gains last just about as long as the substances/levels that the tests measure.

You can absolutely make muscle gains and retain them, but it takes a lot of physical work along with a ton of research (to choose the right drugs and make the right cycles).

If I'm reading these right, they look more like HGH - hard to test for and easier to keep gains from.

I'm pretty ignorant on the rate of retention/loss for HGH, but I understand that it is reported to have better muscle retention than most, if not all, AAS.

The critical factor for Myostatin and NCOR-1 suppressors (in sports at least) will be how easily the gains are retained in the absence of the suppressors.

Edit - Will also be important if the suppressors trigger hyperplasia rather than just hypertrophy. As I understand things, once you add more muscle fibers, they don't go away.

interdasting

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