USP Labs VERSA-1: Aegeline/Anacylcus?
So the new USP Labs product VERSA-1 recently released the compound ingredients below.
1 capsule:
Proprietary Blend 400 mg
[b]N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide[/b], Cytidine 5’-diphoscholine
As many people have already pointed out, the first compound listed is aegeline, which shows antihyperlipidemic, antihyperglycemic and antidyslipidemic properties in diabetic rat models. Also, it has been postulated to be a beta(3)-adrenergic receptor agonist as well. This is one of the ingredients in the new formulation of OEP, and certainly makes sense for inclusion in a weight loss formula and makes sense based on the results of leaning out that some users of VERSA-1 reported. However, it is the purported anabolic properties of OEP that I am more interested in. If you look at the third reference cited by USP Labs, they list Sharma et al., which is actually anacyclus pyrethrum. [url]http://www.ncbi.nlm.nih.gov/pubmed/22473789[/url]
Following up on this, it seems more likely that this compound is responsible for the anabolic properties and lean mass gains reported by users in the test logs. Taken from the Sharma abstract:
[QUOTE]Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations... Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential... [/quote]
Additionally, an earlier publication from 2010 from the same group (full study is available on pubmed here, [url]http://www.ncbi.nlm.nih.gov/pubmed/20727332[/url]) demonstrated improved sexual behavior in male rats following an ethanol extract of anacyclus pyrethrum, but more interestingly, also demonstrated [b]significant improvements in body weight and sexual organs[/b] (testes, prostate, seminal vesicles, and epididymides), similar to administration of testosterone. This led the authors to conclude that anacyclus had both anabolic and androgenic properties.
Now, while I'm not keen on the idea of an enlarged prostate, this does make this compound seem very interesting. But the question is then, is N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide found in anacyclus pyrethrum?
THEHUGE had experimented with anacyclus awhile back ([url]http://forum.bodybuilding.com/showthread.php?t=124866411&page=1[/url]), and I know that this is the ingredient in PES' Anabeta, which also generated a lot of buzz in the beginning, although I haven't heard much about it lately.
So I was curious to see what others thoughts were on this subject and whether anyone knows if aegeline is also found in extracts of anacyclus pyrethrum.
USP Labs VERSA-1: Aegeline/Anacylcus?
This is my understanding of the reference USP cited: (3)Sharma V, Boonen J, Spiegeleer BD, et al.
- Aegeline is not the same as anacylcus. However the extract from both contains N-Alkylamide.
-The phytochemical studies carried out in A. pyrethrum suggested presence of alkylamide and polymeric carbohydrates. Both have been reported to possess potent androgenic activity; hence, the alkylamide content found in the investigated ethanol solution extract may be implicated for the observed effects for A.pyrethrum extract in treated rats.(Sharma V, Boonen J, Spiegeleer BD, et al).
-Using that study(3) as a reference for aegeline is a questionable. I would like for USP to explain the specific relationship of their product and the alkylamides in question in that publication. N-alkylamides can also occur in plants such as Ecinacea.
-Stacking: The ingredients label on OES listed it as aegeline and the chemical name N-[2-hydroxy-2(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide for versa-1. Since we don't know the specific amount in both of them, can they be stacked together?
-Other scientist would argue that the anabolism that aegeline induces is likely restricted to adipocytes since humans are extremely insensitive to beta(3)-AR agonism.
-In my opinion, I don't think there is enough evidence to discredit USP and also I don't think that the studies they presented strongly back their claim. Hence the beta testing was somewhat used as a non clinical human trial for this product.
-I am a fan of USP labs for their innovation. I really really hope that they are researching the safety of their product enough. Some in the supplement industry recycles the same old products and switched the name to their chemical name or something else because they think we are all dumb. More and more people are beginning to actually research their claims and their products. We need to call out all the cabbage as soon as we see them.
USP Labs VERSA-1: Aegeline/Anacylcus?
[QUOTE=Magnetotropic;1010453183]"N-alkylamide" does not refer to any specific compound. It is a simply nomenclature for a [i]very[/i] broad class of compounds.[/QUOTE]
I am sorry if I wasn't clear. I know N-alkylamide does not refer to any specific compound. I was able to get the full papers from pubmed. I was speculating on the reason USP lab cited that paper(3). The only relationship I can find between Aegeline and anacyclus is the fact that their extact contains some kind of alkylamide. That is the reason I also stated that Ecinacea extract also contain the same class of compounds.
USP Lab Reference.
(1)Antihyperglycemic and antidyslipidemic agent from Aegle marmelos.
(3) Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC*. (Questionable)
Segansational has a very good point about why that paper was cited as part of the research that back their claims. After reading both references (1) and (3) by USP labs, I can find no relationship between these two except that some kind of alkylamide was isolated. Even though I have my reservations, I was also careful not to jump into any conclusion or discredit any claim until USP lab can explain this.
