View Full Version : CLA and Fish Oil
Dave P
04-14-2006, 01:49 PM
So whats the verdict on these 2 being mutually exclusive? It sais on the CLA bottle not to mix with Chitosan products (no idea if Fish Oil has that). Id like to keep taking both but if im just shooting myslef in the foot ill stop.
young_squatter
04-14-2006, 01:50 PM
Taking both is fine.
LMAO. Fish Oil is linolenic acid. Chitosan is the faux-proclaimed "Fat blocker". Two completely different things.
Othelo
04-14-2006, 02:28 PM
I believe the issue is absorption, as in they compete rather than compliment each other. I take them at least 4 hours apart, just to be on the safe side.
Its not a matter of interaction at all.
I believe the issue is absorption, as in they compete rather than compliment each other. I take them at least 4 hours apart, just to be on the safe side.
Its not a matter of interaction at all.Link? Citation? Anything?
Napalmed2Death
04-14-2006, 03:35 PM
Found this interesting study, it seems to suggest that Fish Oil if taken with CLA will cancel out the benefits of CLA.
Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue.
Ide T.
Laboratory of Nutritional Biochemistry, National Food Research Institute, 2-1-12 Kannondai, Tsukuba Science City 305-8642, Japan. idetaka@nfri.affrc.go.jp
The interaction of dietary fish oil and conjugated linoleic acid (CLA) in affecting the activity of hepatic lipogenic enzymes and gene expression in liver and adipose tissue was examined in mice. A diet containing 1.0% CLA, mainly composed of 9cis,11trans- and 10trans,12cis-octadecadienoic acids at equivalent amounts, greatly decreased adipose tissue weight and serum concentrations of leptin and adiponectin and was accompanied by a downregulation of the expression of various adipocyte-abundant genes in epididymal adipose tissue. However, CLA increased the serum insulin concentration fourfold, and it caused hepatomegaly, with huge increases in the triacylglycerol level and the activity and mRNA levels of hepatic lipogenic enzymes. Different amounts (1.5, 3, and 6%) of fish oil added to CLA-containing diets dose-dependently downregulated parameters of lipogenesis and were accompanied by a parallel decrease in the triacylglycerol level in the liver. The supplementation of CLA-containing diets with fish oil was also associated with an increase in fat pad mass and mRNA levels of many adipocyte-abundant genes in epididymal adipose tissue along with a normalization of serum concentrations of leptin and adiponectin in a dose-dependent manner. However, in mice fed a diet containing 1.5% fish oil and CLA in whom fat pad mass was still low and comparable to that in the animals fed CLA alone, the serum insulin concentration greatly exceeded (twofold) the value observed in mice fed CLA alone, indicating an aggravation of insulin resistance. This hyperinsulinemia was ameliorated with increasing amounts of fish oil in the diets. Apparently, many of the physiological effects of CLA can be reversed by fish oil.
Wrong. That study you posted shows Fish Oil to be beneficial in counteracting the increased serum triglyceride levels caused by CLA, not the CLA itself. It makes sense too. Fish Oil, rather linolenic acid is a mild PPAR-alpha (a gene expression responsible for fat oxidation) agonist and CLA is a PPAR-gamma (a gene expression responsible for fat storage) antagonist. See how that works? So if anything, Fish oil makes CLA useful. CLA isn't great standalone. It will leave you insulin resistant due to decreased fat storage and more FFA's in the blood not being oxidized. Fish oil via the PPAR-alpha pathway, helps oxidize those FFA's.
Dave P
04-14-2006, 03:47 PM
Lamens Terms?
Other than this bit that is...
Apparently, many of the physiological effects of CLA can be reversed by fish oil.
Lamens Terms?
Other than this bit that is...
What I said in post #7.
ckohl23
04-20-2006, 08:09 AM
Wrong. That study you posted shows Fish Oil to be beneficial in counteracting the increased serum triglyceride levels caused by CLA, not the CLA itself. It makes sense too. Fish Oil, rather linolenic acid is a mild PPAR-alpha (a gene expression responsible for fat oxidation) agonist and CLA is a PPAR-gamma (a gene expression responsible for fat storage) antagonist. See how that works? So if anything, Fish oil makes CLA useful. CLA isn't great standalone. It will leave you insulin resistant due to decreased fat storage and more FFA's in the blood not being oxidized. Fish oil via the PPAR-alpha pathway, helps oxidize those FFA's.
ok, but how do you explain the part that says there was an increase in fat-pad mass when fish oil was added to the 1.0% CLA diet? the purpose of CLA is to decrease fat storage but if taking fish oil just puts the fat back in adipose tissue, then what are we accomplishing?
ok, but how do you explain the part that says there was an increase in fat-pad mass when fish oil was added to the 1.0% CLA diet? the purpose of CLA is to decrease fat storage but if taking fish oil just puts the fat back in adipose tissue, then what are we accomplishing?
i was wonderng this too!
Different amounts (1.5, 3, and 6%) of fish oil added to CLA-containing diets dose-dependently downregulated parameters of lipogenesis and were accompanied by a parallel decrease in the triacylglycerol level in the liver.
So it seems to me that fish oil and CLA reduce fat accumulation.
Tons of good research on Fish Oil in this link...its your one stop source:
http://jn.nutrition.org/cgi/content/full/133/7/2239