Tren cough and fat burning explained by Pheedno

[Voodoo]

Tren- Fat burning and "fina cough" both from prostaglandin metabolization Posted on AR & IBB as well-


It's been widely disussed of Trens fat burning properties through rises in IGF and Prostaglandins. While IGF is a fairly well known substance in the bodybuilding world today, prostaglandins are fairly unknown in terms of formation and roles in the body.
So below, a brief dicription of prostoglandins and their role in fat burning, "fina cough", and why a person going through Tren administration can experience it's fat burning effects without the dreaded "Cough"

The term prostaglandin comes from the word-Prostate. The first prostoglandins were first dicovered in semen about the mid 1930's and it was thought that prostaglandins were made from the prostate. Since this time, it has been dicovered that most prostaglandins are not even constructed in the prostate.

Prostaglandins are made by two different pathways(Cyclooxygenase and Lipoxygenase), and considering prostaglandins are a group of about 20 lipid cells, they have contrary function; responsible for stimulating as well as alleviating inflammation(Inflammation stimulation is the rapid metabolism of them expelled through the bronchials), regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, induce sleep, mediate lipid release, and regulate metabolism is various tissue.

Prostaglandins are synthesized from arachidonate(Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways, compete with one another to form prostaglandins(as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E and F plus thromboxane and prostacyclin are made. Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.

Being that prostaglandins from either pathway, are still fatty acids of a group, they mediate lipid release and controll tissue metabolization, so fat burning is a luxerry of either pathway of formation. It's the pathway from which they are constructed that dictates "fina cough". As prostaglandins made from the Cyclooxygenase pathway dictate muscle constriction and platlet aggregation, and the Lipoxygenase pathway dictates bronchial constriction(the main form of expulsion)


Refs:
Cackatoo Press
Columbia Encyclopedia 6th Edition
Science Daily Magazine

[user43390fgui8t]

this is a great post....
tren cough has been talked about and worried about for years. its good to see someone trying to explain it.

[Voodoo]

Bump for more views.

[PlantUrTulips]

great post.... although I have yet to experience tren cough. *crossing my fingers*

[user43390fgui8t]

im gonna stick this for a bit... its something that needs to be read about.

[pogue]

NAC and a lot of GLA should get rid of the cough if Prostaglandins are whats causing it. The inflammatory prostaglandins such as arachidonic acid are formed through the COX-2 pathway which stuff like asprin inhibits.

The EFA GLA also inhibits this formation, so in high doses it should be effective in reducing it. But that would probably also reduce protein synthesis to some degree.

http://en.wikipedia.org/wiki/Prostaglandins

[Voodoo]

Originally posted by pogue
NAC and a lot of GLA should get rid of the cough if Prostaglandins are whats causing it. The inflammatory prostaglandins such as arachidonic acid are formed through the COX-2 pathway which stuff like asprin inhibits.

The EFA GLA also inhibits this formation, so in high doses it should be effective in reducing it. But that would probably also reduce protein synthesis to some degree.

http://en.wikipedia.org/wiki/Prostaglandins


As always Pogue, full of interesting info/links to read and ponder.

[wildturkey]

What an awesome thread, thumbs up guys.

Nick.

[Big Cat]

Tren has been used back in the day with a variety of anti-inflamatory drugs that were supposed to aid fat loss, and it did not stop the cough. So I doubt there is much merit to this theory.

Moreover androgens and IGF's tend to decrease the synthesis of prostaglandins. prostaglandins signal inflammation and damage and increase succeptibility to androgens and IGF's. Logically when the demand for IGF's and androgens is met, the feedback is given to reduce PG synthesis. This has been confirmed in a variety of studies before. Again not quite in favour of this theory.

There is also no concensus on whether or not more prostaglandins lead to loss or gain of bodyfat. Because while PGF2A for example reduces body-fat, its not produced to a great extent in fat tissue. Most often PGE's and PGI2 are named, and those usually decrease fatburning. Then on the other hand stable expression of COX proteins inhibits differentiation of adipose tissue. So it may be equally or even more likely, that tren increases fat loss by reducing PG synthesis, as androgens tend to do.

[Voodoo]

I had been wondering a few things, since I have never used Parabolan, do you know if people got the cough with it as opposed to tren act or tren enan?

Although I have never experienced "the cough", it sounds as though it's and allergic reaction and sounds very much like an asthma attack. Could this be the case? Could it be the oil or do you think it could be the tren?

[UncleJohn]

I have gotten that cough feeling from none tren products immediatly after injection from undergroud labs.... Acctually got it today...

[Big-Golden]

I feel there are 2 types of the "cough". I've experienced both. (separately)

1. A strong cough starts right after injection and makes you feel like you just swallowed a liquid down your wind pipe. This cough is hard to control, and it acts more like a reflex.

2. The second kind take place a few minutes to 15 minutes after you've injected. It seems to occur when you start to work in the oil by walking around, or massaging it. This cough feels more like your lungs are expelling a chemical. It tastes a little funny, and reminds me of an alcohol, but its nothing like ethanol. This cough is very controlable, and its just a little irritating to your throat.

[Big Cat]

Originally posted by Voodoo
I had been wondering a few things, since I have never used Parabolan, do you know if people got the cough with it as opposed to tren act or tren enan?

Although I have never experienced "the cough", it sounds as though it's and allergic reaction and sounds very much like an asthma attack. Could this be the case? Could it be the oil or do you think it could be the tren?

Well for one it definitely confirms that trenbolone is unlikely to be the culprit. Similar "coughs" appear with underground stuff. These can be attributed to impurities or different ratio's of ingredients. Nothing conclusive, but since Parabolan was a legit product, it would make it likely that they used another product in the solvens or another ratio of products in the solvens that resulted in the cough being more frequent.

[Voodoo]

I've always wondered about the solvents/extractors in homebrew.....Some guys are using Heet.....which breaks the pellets apart and is supposed to evaporate, (shrugs shoulders).....I just don't know about that....It could leave a residue behind....


I've never heard of other UG gear causing a cough though. Maybe the solvent is the cause in some cases.....What else are they using besides BA or BB these days? In homebrew what are they using to separate the tren from the pellets?