New Plant Growth Hormone Ester

[CognitiveNutrition]

-Description-

Centrophenoxine (meclofenoxate) is a potent version of PGH (Phyto Growth Hormone) [ParaChlorphen OxyAcetic acid] chemically bonded to an ester DMAE.

Chemical Name: 2-dimethylaminoethyl ester of p-chlorophenoxyacetic acid

-Neurochemical Effects-

- Raises Brain Metabolism (Mental Energy Enhancer)

- Boosts SOD & Catalase levels (A very potent Antioxidant)

- Raises Phospholipid turnover [Increases Neuronal Cellular Membrane Fluidity] (Improves Faster Brain functioning at the neuron level)

-Dose-

500-2,000 mg daily

-When can I feel it?-

Works within an hour to a few days.





I've gotten alot of feedback on this for brain fog and anyone who has ever done alot of drugs that it clears up the mind very well.

[CognitiveNutrition]

Vestn Ross Akad Med Nauk. 1995;(6):7-16.
[Comparative quantitative pharmacological-EEG analysis of the effects of psychostimulants]

Amphetamine, caffeine, sydnocarb, meclofenoxate, adapromine, midantan, and nomifensine were studied for their effects on bioelectrical activity and Fourier EEG power spectra of the sensomotor cortex, dorsal hippocamp and lateral hypothalamus of freely behaving awake rats. The drop in the absolute power of all frequency ranges with the enhanced power of fast beta 1,2-ranges was common to the action of psychostimulants. In addition to the common properties, specific features of their action were revealed. Amphetamine, meclofenoxate, and nomifensine were found to increase the amplitude of the dominant peak in the theta-range and amphetamine shifts the frequency of the dominant peak to the region of faster ranges. The agents-induced electrophysiological changes correspond to the varying degrees of activation of the central nervous system, causing the optimization of behavioral functions, abolition of fatigue and drowsiness and enhancing physical and mental working capacity.

[CognitiveNutrition]

Centrophenoxine stimulates the brain and fights against its ageing (June 1, 2003)

Centrophenoxine, also known under the name of M?clof?noxate, was developed in 1959. It has been largely used at the man for more than thirty years against the cerebral disorders related to ageing and the deterioration of the memory. The catch of Centrophenoxine increases the consumption of glucose and oxygen of the brain, essential to the manufacture of energy, as well as the production of carbon dioxide. It eliminates accumulation from potassium and lipofusion. The transfer of potassium and sodium through the membranes is vital for a good cellular communication and can be inhibited by the lipofusion. Centrophenoxine is very effective in the treatment of various disorders related to cerebral lesions due to ageing, with a stroke, drugs or chemicals including excessive alcohol consumption. It also provides a protection against the chemicals of the environment.

Centrophenoxine is made up of two biochemical substances: di?thylamino?thanol (DMAE) and the parachloroph?noxyac?tate (PCPA). The DMAE is a component naturalness which one finds in food like fish. It is also a metabolite of choline, present naturally in the organization of the man. The PCPA is component synthetic similar to a variety of phytohormones called ?auxine?. Both are, inter alia, of powerful antioxidants able to protect the brain from the radicalizing lesions. The PCPA is also an analogue of the acid pyroglutamic (PCA) naturally present in the brain

The beneficial therapeutic effects of Centrophenoxine were observed in particular in cases of cerebral atrophy, lesions of the brain, states post apoplectic (after a stroke), of chronic alcoholism or intoxications with barbiturates.

Clinically shown effects

Clinical studies on patients expressing of the symptoms such as confusion, the psychosomatic asthenia (extreme weakness), of the disturbances of the memory or the intellectual concentration?, reveal outstanding progress after only a few weeks of treatment.

Scientific work published in the European literature brought back a clear improvement of symptoms as tiredness, irritability, a state of confusion or a loss of memory among patients geriatric treated by Centrophenoxine.

In two small studies control, of the patients suffering from late dyskinesy, a neurological disorder characterized by various movements involuntary and abnormal of the mouth, the language, the jaw, the neck or the ends, generally caused by the administration of antipsychotic, Centrophenoxine causes a very important reduction of these symptoms at nearly two thirds of the patients.

The regular catch of Centrophenoxine can prevent mental deterioration. It improves the performances of the memory at people in good health as at those which are reached of insanity.

In a bearing double blind study on 50 patient?s old suffering from insanity of levels means, Centrophenoxine produces a stimulation of the memory significantly more important than a placebo does it. It also involves a better state general.

A geriatric study as a double blind man suggests that Centrophenoxine increases the capacity of transfer of new information in the secondary memory. This best operation of the memory is accompanied by a greater capacity to discharge activities of the daily newspaper. The patients expressed the beneficial effects of the treatment in term of improvement of the vigilance and by a feeling of wellbeing.
Reinforce the energy of the brain

Centrophenoxine has a stimulating effect on operation of the brain. It increases the neuronal consumption of glucose and oxygen as well as the production of carbon dioxide, thus raising the rate of manufacture of ATP.

The demonstration of the capacity of Centrophenoxine to reinforce the resistance of cerebral cells of rats, mouse and rabbits with various forms of deprivation of oxygen including the intoxication with cyanide, the reduction of the atmospheric pressure and the oxygen pressure in the breathed air brings the confirmation which it acts through the reinforcement of alternative ways of the metabolism of glucose.
Researchers observed, in rats, by electroencephalograms an increase constant in the metabolic cerebral activity even under conditions of hypoxia (low oxygen levels in the brain). Other experiments relating to old rats showed that Centrophenoxine increases the electric cortical activity of almost 40% at the same time in adult or old animals. The cervical electric activity being the reflection of the metabolic activity of the brain, that shows, there still, that Centrophenoxine is really one neuro-?nergisant.

A cholinergic superior

The DMAE, principal composing of Centrophenoxine, is converted into choline by the liver by the addition of a group methyl (CH3). Centrophenoxine provides thus to the brain of the DMAE and choline. The latter, a substance similar to the vitamine B, is at the same time brought by the food and is produced in the body. It essential with the optimal operation of the brain and is used to manufacture other biochemical substances like acetylcholine, a neuro-transmitter essential to the memory, the training and the intellectual concentration. It also makes it possible to produce two essential components of the cellular membrane like the phosphatidylcholine or sphingomyelin.

The organization manufactures choline but a broad part is brought by the food. Thus, the liver, the meat or the eggs bring high quantities of choline but or our modern food the processed dietary foodstuffs vegetarians contain little of it. A food too low in choline is incompatible with a good health.

Between the meals, at the man, the normal blood choline levels vary from 8 to 12 microphone-moles. Choline runs in two directions through the h?mato-cerebral barrier: when its blood levels are below 14 microphone-moles, it goes from the cells of the brain towards blood flow. When its levels are above 14 microphone-moles, it circulates of blood towards the brain.

In situations of fast like, for example, between the meals, when it penetrates blood flow while coming from the cerebral cells, choline is derived (to manufacture acetylcholine) by car-cannibalization from membrane phospholipides. An insufficiency out of choline can sometimes lead to a permanent car-cannibalization, a membrane rupture and with died of the cells.

It should be stressed that a certain number of studies associated an excess of neuronal choline car-cannibalization during the life the genesis of the disease of Alzheimer.

The rich food consumption in choline, by supplement nutritional of lecithin choline, DMAE or Centrophenoxine can increase the plasmatic choline levels up to 30 microphone-moles and even more still with, for results, of the higher cerebral acetylcholine and choline levels.

Nutritional choline supplements such as the choline chloride or choline bitartrate have a weak biodisponibility and are often destroyed practically to 60% by the bacteria of the intestine.

Centrophenoxine is a source of blood and cerebral choline ideal for several reasons. Initially, the bacteria of the intestine do not digest the DMAE and the liver converts it quickly and easily into choline progressively with the needs for the organization. The DMAE brought to the neurons by Centrophenoxine inhibits the enzyme choline d?hydrog?nase, thus preventing choline from being oxidized in an irreversible way in betain and maintaining the levels blood/cerebral of choline higher than they would be it differently. Lastly, the DMAE crosses much more easily than choline the h?mato-cerebral barrier.

Centrophenoxine is thus probably the most effective means to raise the blood and cerebral acetylcholine and choline levels. In same time, it protects the neurons from the spectrum of the car-cannibalization of choline.

[CognitiveNutrition]

Part 2



A powerful antioxidant

Imre Zs-Nagy, the father of Centrophenoxine, is persuaded that this one contributes its greater share to the health of the brain thanks to its antioxydant effects. It insists on the fact that it is more effective to bring DMAE inside the brain than the DMAE itself.

Inside the cells of the brain, the DMAE is converted into phosphatidyl choline. Same manner, phosphatidyl DMAE is incorporated in the membranes of the nervous cells and nearly 40% remains there more 24heures in the place of choline. With the difference of the phosphatidyl choline, phosphatidyl DMAE is a powerful hunter of free radicals and, in particular, neutralizes the radical hydroxyl very effectively.

Various experiments were carried out on the noxious effects of the radicals hydroxyls on the nervous cells and proteins like on the beneficial action of Centrophenoxine/phosphatidyl DMAE in the combat of these effects. Thus, for example, because it supports the formation of the radical hydroxyl, an iron overload in the liquid c?r?bro-spinal is extremely dangerous. Moreover more low dose accelerates the ageing of young rats. The synaptic membranes of rats were protected in a considerable way against this type of iron overload by a preprocessing with Centrophenoxine.

When one compared proteins of the membranes of old rats of 2, 12 and 24 months, one noted an increase in proteins of high molecular weight and a reduction in low-weight proteins molecular. This phenomenon was the result of an increase in the cross connections of proteins caused, during the life, by the attacks of the radicals hydroxyls. A two months treatment with Centrophenoxine reverses this phenomenon in old rats by incorporation of phosphatidyl DMAE in the neuronal membranes which reduces the cross connections of proteins. In fact, Centrophenoxine renovates the membranes synaptic of old rats.

When young, adult and old rats are treated during 40 days with Centrophenoxine, a significant increase in the fluidity of the neuronal membrane occurs in the three groups of animals.

With the age, the neuronal membranes become generally less fluid and more rigid because of the lesions caused by the free radicals hydroxyls and of the cross connections of proteins. The reduction in the fluidity of the neuronal membranes deteriorates their capacity to lead the pulses. This fluidity decreasing with the peroxidation of the lipids induced by the radical hydroxyl, the results were interpreted like a new proof of the effect anti-radical hydroxyl and renovating cells of the brain of Centrophenoxine.

Researchers gave for two months of Centrophenoxine to old rats of 11/2, 13 and 26 months. They had already observed, at old rats (26 months), an important reduction (50%) of the production of total ARN and ARN messenger.

They noted that Centrophenoxine increased the synthesis of ARN significantly, practically bringing it to the levels of that of an adult rat (13mois).

The ARN (derivative of the ADN in the cellular core) makes it possible the cells to receive their ?instructions? of nuclear genes and that new proteins replace those which worn or are damaged by the radical hydroxyl. Normally, in the brain, the production of ARN and proteins falls with the age. Centrophenoxine fights this process.

To maintain a level important permanent of phosphatidyl DMAE in the membranes of the neuronal cells by a regular catch of Centrophenoxine could constitute an effective strategy to be opposed to the ageing of the brain at the same time as a means of repairing or of regenerating the cellular membranes damaged by the radical hydroxyl even late in the life.

Eliminate the lipofusion

One of the first data coming from animal studies shows that Centrophenoxine very effectively reduces the levels of lipofusion. The lipofusion is a residual product, made up of fragments of membranes, damaged proteins and fatty acids. It accumulates in the cells with the passing of years until sometimes occupying there 30% of their volume in old animals. As the cells store more lipofusion, they function less better and can die quickly when a critical volume is reached. One calls sometimes the lipofusion the pigment of ageing. It appears indeed in the form of spots chestnuts on certain parts of the body. On the hands, one then calls them flowers of cemetery and, on the face, spots of old age.

It was shown that a prolonged administration of Centrophenoxine to old animals in good health involves an important reduction of the lipofusion.

In mice, a notable reduction is observed at the end of six weeks. A study on rats old showed a fall from 25 to 42% of the levels of lipofusion in various areas of the brain after eight weeks of treatment. A reduction in the lipofusion as well as an increase in the antioxydant enzymes in the c?r?belleux cortex were noted after six weeks of treatment in old rats of 6, 9 and 12 months. The life expectancy of the animals taking of Centrophenoxine was much longer than that of those which did not receive any. This study is the only one which shows scientifically that the catch of Centrophenoxine prolongs the life expectancy of the animals. Animal studies and on the man showed that low levels of lipofusion are correlated with a healthy cellular operation while high levels of lipofusion are synonymous with a cellular bad health.

Old animals whose levels of lipofusion had been reduced by Centrophenoxine had their memory and their capacity of training restored on levels similar to those of young animals.

Scientific work showed that Centrophenoxine can decrease the quantities of lipofusion in the nervous cells, suggesting that its beneficial effects on mental operation lunatic people are partly due to this action. Many researchers think that benefits are also produced by the means of an improvement of the cellular metabolism.

References:
Centrophenoxine: effects one aging mammalian brain, Nandy K, 1978, J Am Ger Ploughshare 26, 74-81.
With survey of the available one dated has new nootropic drug, Zs-Nagy and Al, 1994, BCE-001 Ann NY Acad sci 717, 102-14.
Centrophenoxine increases the misses of total and mRNA synthesis in brain cortex of old rats: year explanation of its action in terms of the membrane hypothesis of aging. Zs-Nagy and Al, 1984, Exp Gerontal Geriatr 9, 17-30.
The differential effects of meclofenoxate one memory loss in the elderly, Marcer D et al., 1977, Age and ageing 6, 123-31.6
Age-related changes in the multiple links activity of the rat brain parietal cortex and the effect of centrophenoxine, Roy D. et al., 1988, Exp Gerontal 23, 161-74.
Choline: important year nutrient in brain development, liver function and carcinogenesis, Zeisel S, 1992, J Am coll Nut 1, 478-81.
Choline, year essential nutrient for humans, Zeisel, S and Al, FASEB J 5, 2093-98.
Deteriorations in the molecular weight distribution of proteins in rat brain synaptosomes during aging and centrophenoxine treatment of old rats, Nagy K and Al 1984, Mech Age Dev. 28, 171-176.
Fluidising effects of centrophenoxine in vitro one brain and liver membranes from different age groups of mice. Wood and Al 1986, Life Sci 39, 2089-95.
Effects of centrophenoxine one lipofusion pigment in the nervous system of old rats, Riga S and al.1974, Brain LMBO 72, 265-275.
Effects of centrophenoxine one body composition and some biochemical parameters of demented elderly people. Fulop T Jr and Al, 1990, Arch Gerontal Geriatr 10, 239-51.