Steroid Use Causes Long-term Aggression

[seanconnery]

Stumbled across this article this morning. Old, but still interesting.

http://www.sciencedaily.com/releases/2003/11/031121070805.htm

Would have posted in the Steroids forum, but am too young to.

[scott_donald]

i will post it ther for you if you want...

good read tho...

[bgzee]

Probably something that shouldnt go unnoticed:


, Melloni and doctoral student Jill Grimes have been studying how steroids used during adolescence may permanently alter the brain's ability to produce serotonin.

[jweave23]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8855834

[seanconnery]

For those too lazy, this is what jweave23 posted:



J Clin Endocrinol Metab. 1996 Oct;81(10):3754-8. Related Articles, Links


The effects of supraphysiological doses of testosterone on angry behavior in healthy eugonadal men--a clinical research center study.

Tricker R, Casaburi R, Storer TW, Clevenger B, Berman N, Shirazi A, Bhasin S.

Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA.

Anecdotal reports of "roid rage" and violent crimes by androgenic steroid users have brought attention to the relationship between anabolic steroid use and angry outbursts. However, testosterone effects on human aggression remain controversial. Previous studies have been criticized because of the low androgen doses, lack of placebo control or blinding, and inclusion of competitive athletes and those with preexisting psychopathology. To overcome these pitfalls, we used a double-blind, placebo-controlled design, excluded competitive athletes and those with psychiatric disorders, and used 600 mg testosterone enanthate (TE)/week. Forty-three eugonadal men, 19-40 yr, were randomized to 1 of 4 groups: Group I, placebo, no exercise; Group II, TE, no exercise; Group III, placebo, exercise; Group IV, TE plus exercise. Exercise consisted of thrice weekly strength training sessions. The Multi-Dimensional Anger Inventory (MAI), which includes 5 different dimensions of anger (inward anger, outward anger, anger arousal, hostile outlook, and anger eliciting situations), and a Mood Inventory (MI), which includes items related to mood and behavior, were administered to subjects before, during, and after the 10 week intervention. The subject's significant other (spouse, live-in partner, or parent) also answered the same questions about the subject's mood and behavior (Observer Mood Inventory, OMI). No differences were observed between exercising and nonexercising and between placebo and TE treated subjects for any of the 5 subdomains of MAI. Overall there were no significant changes in MI or OMI during the treatment period in any group. Conclusion: Supraphysiological doses of testosterone, when administered to normal men in a controlled setting, do not increase angry behavior. These data do not exclude the possibility that still higher doses of multiple steroids might provoke angry behavior in men with preexisting psychopathology.

Publication Types:
Clinical Trial
Randomized Controlled Trial


The study I posted reported on tests performed in hamsters. ;) They supposedly have "similar brain circuitry to human adolescents".

[Jimineye]

Originally posted by seanconnery
For those too lazy, this is what jweave23 posted:



The study I posted reported on tests performed in hamsters. ;) They supposedly have "similar brain circuitry to human adolescents".

Good stuff... somehow I believe that a lot of adolescents have a the brain of a hamster. :D

So 600mg is safe for the average male, but don't most people do more than 600mg?

[SupaNatural]

Originally posted by seanconnery
The study I posted reported on tests performed in hamsters. ;) They supposedly have "similar brain circuitry to human adolescents".

Adolescent hamsters.:)

The study posted by weave was done on adults, and did not measure serotonin production, which would have been nice to see, especially in the group under 25.

[seanconnery]

Originally posted by Jimineye
So 600mg is safe for the average male, but don't most people do more than 600mg?

I've seen cycles prescribing something like 2000mg.

What'd be really interesting is a study on the psychotropic effects of PCT drugs (clomiphene, 6-oxo) on subjects coming off a cycle, with low test and all.

[marc0g]

in my opinion serotonin defeicency is more opt to cause anxeity/depression then rage but really depends on genetic make up i guess

[size]

Originally posted by jweave23
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8855834

Good stuff mate. I was going to post it. :)

[Ragnarok]

Originally posted by marc0g
in my opinion serotonin defeicency is more opt to cause anxeity/depression then rage but really depends on genetic make up i guess

No, you are stating a fact about low seratonin. Anxiety and depression. I am THE expert in this area. HOWEVER, a recent study publicshed by the Society for Neuroscience, stating essentially that low seratonin may lead to an overall insensitivity to consequences of the subject's actions:


"Serotonin and Judgment
Depression can hit at any age. More than the blues, the overall feeling of doom can trigger some people to kill themselves. Researchers now are looking at this behavior from a new angle. Studies show that low levels of the brain chemical serotonin can in part lead to an overall insensitivity to future consequences, setting off impulsive and aggressive behaviors and perhaps culminating in suicide. By selectively restoring the chemicals' activity researchers hope to prevent destructive behavior as well as head off suicide -- the eighth leading cause of death in the U.S. "

This is only the first paragraph. If you would like to read more, you can find it here:

http://web.sfn.org/content/Publications/BrainBriefings/serotonin.html

[marc0g]

interesting info man....

[nicesocks]

I'm sorry I don't have any reference article but I read in the paper not too long ago the following (numbers are all guestimates sorry):

A test is setup with males where they are asked if they would like 100 dollars now, or 300 dollars a week later.

Something like 95% took the 300 dollars a week later.

Then the same test was performed but prior to asking the question the males where shown pictures of scantily clad women.

This time it was about 60% of the men that chose the 300 dollars later.

The results are supposed to state that with increase in testosterone (after seeing the pictures) the mens rationality dropped and the concern with the future with it.

This backs up what ragnarok quoted, where the lack of serotonin lead to "insensitivity to future consequences".

I might be reaching here but I thought I'd post it, i found it quite interesting.

[DMG]

Originally posted by seanconnery
I've seen cycles prescribing something like 2000mg.

What'd be really interesting is a study on the psychotropic effects of PCT drugs (clomiphene, 6-oxo) on subjects coming off a cycle, with low test and all.



Nobody should use 6-OXO coming off a real steroid cycle. 6-OXO isn't nearly strong enough, maybe for PH/PS, but not real steroids. If you were to use 6-OXO, you'd probably stand to lose all the gains you made on steroids. You gotta use Nolvadex, clomid, or Priviron, along with HCG.

[djzeo]

quote:
--------------------------------------------------------------------------------
, Melloni and doctoral student Jill Grimes have been studying how steroids used during adolescence may permanently alter the brain's ability to produce serotonin.




Serotonin haha i kissed mine goodbye long ago! Thank you stupid rave parties.

[kj2833]

Originally posted by djzeo


Serotonin haha i kissed mine goodbye long ago! Thank you stupid rave parties.

5-HTP

[JordacheJeans]

roid rage is a myth. it's an excuse for people with little or no self control to act out. my mood is definitely way better when i'm on cycle.

[kj2833]

Originally posted by JordacheJeans
roid rage is a myth. it's an excuse for people with little or no self control to act out. my mood is definitely way better when i'm on cycle.

unless im hungry :D