why does 1 test lower libido

[scott_donald]

why does it do this...

[d piece]

It causes your natural testosterone to shut down (like all exogenous androgens eventually do) and it does not possess the properties testosterone does to act as a sex hormone, thus you will not feel sexual desire as strongly or at all as well as possible impotence.
I don't know if you were looking for an answer that basic, if you wanted something more scientific let me know.

[scott_donald]

Originally posted by d piece
It causes your natural testosterone to shut down (like all exogenous androgens eventually do) and it does not possess the properties testosterone does to act as a sex hormone, thus you will not feel sexual desire as strongly or at all as well as possible impotence.
I don't know if you were looking for an answer that basic, if you wanted something more scientific let me know.

ye i understand that much... but wanted more info scientifically... add in also why 4ad and others aid libido...

[buddha]

yes this is something i have wondered about too.

[SupaNatural]

Originally posted by scott_donald
4ad and others aid libido...

For one thing 4ad converts to test which stims libido.

[RadicalNemesis]

Originally posted by Supa Freek 420
For one thing 4ad converts to test which stims libido.

If 4AD converts to test, would it not surpress your natural tests as well, the same as 1 test?

[SupaNatural]

Originally posted by RadicalNemesis
If 4AD converts to test, would it not surpress your natural tests as well, the same as 1 test?

Yes, but at the same time natty test is suppressed overall test levels are elevated by the addition of test converted from 4AD.

Elevated overall Test levels will stim libido. Unbeknownst to us is what it is about 1Test that suppresses libido.

[pogue]

Running non-testosterone based hormones will often have this effect. Probably has something to do with the lack of estrogen.

[CrazyTall]

I'd like to add another question. Why does 1Test ,1Ad, and M1t etc cause lethergy? Yet 4 AD seems to do the opposite.

[pogue]

Originally posted by CrazyTall
I'd like to add another question. Why does 1Test ,1Ad, and M1t etc cause lethergy? Yet 4 AD seems to do the opposite.

No one knows. I have a suspicion of why 4AD stimulates the CNS, but I'm writing an article on it.

PA has speculated the lethargy from 1test has something to do with liver toxicity.

[scott_donald]

ok so basically bar the lack of natural test... which everyone knows.. there either is no reason or it is just speculation...

[Spook]

ok so basically bar the lack of natural test... which everyone knows.. there either is no reason or it is just speculation...

There are multiple speculative reasons.

First lets define the major players in libodo. Of course this is a truncated list, but its that way to highlight only the major key points.

first is free test. free test is so important largely because SHBG bound test has trouble crossing in to the cerebro spinal fluid.

see this study for coroboration.


J Steroid Biochem Mol Biol. 1992 Jul;42(6):629-35. Related Articles, Links


The effects of sex hormone binding globulin (SHBG) on testosterone transport into the cerebrospinal fluid.

Hobbs CJ, Jones RE, Plymate SR.

Department of Medicine, Madigan Army Medical Center, Tacoma, Washington.

The movement of testosterone (T) from blood across the blood-brain barrier (BBB) is thought to reflect the combined effects of T's lipid solubility and the presence of circulating binding proteins for T such as albumin or sex hormone binding globulin (SHBG). Since the adult rat lacks a circulating specific high affinity sex steroid binding protein, examination of the disappearance from serum and uptake into cerebrospinal fluid (CSF) of [3H]T before and after SHBG or albumin infusion should provide insight into the function of these two proteins with respect T transport. Three groups of adult male Sprague-Dawley rats were cannulated at the femoral vein and cisterna magna. In a control group (n = 8), [3H]T was given as an intravenous bolus beginning at time zero; multiple serum and CSF collections were assayed for counts per min (cpm) during the subsequent 45 min. Data from these animals were then compared to those seen in animals that received either purified human SHBG (hSHBG) (n = 7) or human albumin (hALB) (n = 6) 10 min prior to the [3H]T infusion. High performance liquid chromatography was used to monitor the metabolic fate of the steroid infusate at the end of each study period. Infusion of hSHBG increased serum concentrations from undetectable to 93.8 nM/l (mean +/- SEM, n = 6). Administration of hALB significantly increased (25.0 +/- 1.2 g/l at baseline, 33.4 +/- 1.6 g/l post-infusion, mean +/- SEM, P less than 0.03, n = 5) the circulating albumin concentration. Comparison of data from each group of animals demonstrated that (1) following an i.v. injection of radiolabeled T, the initial decline in serum [3H]T was significantly reduced (P less than 0.03) in the presence of hSHBG, (2) hALB did not affect the movement of [3H]T out of serum, (3) the time to peak appearance of [3H]T in the CSF was significantly delayed (P less than 0.02) by the presence of circulating hSHBG, and (4) the net quantity of [3H]T found in the cSF under steady-state conditions was not affected by serum SHBG or albumin levels. This study demonstrates that high-affinity steroid binding proteins do modulate the transport of sex steroids across the BBB. Specifically, SHBG delays the clearance of T from serum and slows the rate of T uptake into the CSF during non-equilibrium conditions.(ABSTRACT TRUNCATED AT 400 WORDS)

PMID: 1637726 [PubMed - indexed for MEDLINE]


When it comes to sex drive T is so important because it can be selectively converted in to DHT or estrogen in any given neural tissue bassed on the enzymatic concentration present in the given neural region.

In the dorasal region of the PVN and in the limbic region free T is more redily converted to estrogen because of the high amount of aromatase in those neural regions. This is desirable under normal conditions. estrogen in the dorasal region of the PVN protects agains AVP release. AVP is a big stress neurochemical and can diminish libido because of it. Same reason why aromataze inhibitors make people agitated and cranky.

In different neural tissues conversion to DHT is desirable as that evoke NO synthesis. NO synthesis in the brain is imporant for sexual arousal. This iswhy NO drugs and supps ala viagram are more than just erection enhancers.

So if I had to venture a guess as to why non-aromatizable compounds really mess up sex drive like 1-t. I would say its because the mess up the natural balance of DHT vs. estrogen in different neural regions. Specific neural regions are used to having a lot of one or the other and by overloading said region with a non aromatizable androgen you throw that balance of. The same can be said for aromatase inhibitors.

As for the 4-Ad argument above I would say that 4-AD increases sex drive because of this phenomenon. yes it will supress endogenous test production in the long run but in the short term it raises both T and E and that will raise free T because SHBG is occupied and this increases T clearence in to the CSF. And again its plain old ordinary T so your brain can metabolize it in hte normal fashion and increase libido as a consequence.

[scott_donald]

interesting thanks...

[weightshead]

good post spook

[RadicalNemesis]

Thanks for the info Spook.

Science is cool! I like this section now.

[twista]

Originally posted by RadicalNemesis

Science is cool!

damn straight

[bobcat]

The lethargy caused by M1T is NOT related to liver toxicity...If that were the case, users of AAS like Anadrol and DBOL would be complaining of the same thing and keep in mind that these compounds are more toxic than M1T..

[armz_ha]

can anybody give me a reason to why 1-ad gave me permanant lost sex drive? its getting really close to a year for me and I am nowhere near to getting better or getting any help from doctors- I really want answers... :(

[bobcat]

For the 100th, billionth time, have you tried HCG, Clomid,Nolva, and Proviron? Unless you have fully exhausted ALL FOUR OF THOSE COMPOUNDS, quit your bitching!

[bobcat]

If you have exhausted all your options, go on TRT bro... I was on it for a while because I turned anorexic and ****ed up my endocrine system; then I bounced back...Thank God :) There is hope for you!!!!

[the_invince]

can anybody give me a reason to why 1-ad gave me permanant lost sex drive? its getting really close to a year for me and I am nowhere near to getting better or getting any help from doctors- I really want answers... :(

do you have no sex drive at all? or it's just not as high as it was before?

[armz_ha]

For the 100th, billionth time, have you tried HCG, Clomid,Nolva, and Proviron? Unless you have fully exhausted ALL FOUR OF THOSE COMPOUNDS, quit your bitching!

Since I figured this was the topic- I figured I may get some answers here...:rolleyes:

Well anyways, my testosterone levels are very good and I have tried nolvadex and 6-xoxo- doesn't do a thing.

I just wanted an answer to why 1-ad causes low libido while 4-ad increases it. If I didn't wanna know, I wouldn't have asked...:rolleyes:

[the_invince]

Since I figured this was the topic- I figured I may get some answers here...:rolleyes:

Well anyways, my testosterone levels are very good and I have tried nolvadex and 6-xoxo- doesn't do a thing.

I just wanted an answer to why 1-ad causes low libido while 4-ad increases it. If I didn't wanna know, I wouldn't have asked...:rolleyes:

1-ad lowers libido because it supresses testosterone,(1-testosterone is not testosterone; it's a totally different hormone), 4ad increases libido, because it converts to testosterone. your testosterone levels may seem very good but did you get them tested before you went on cycle? if you didn't you have no way of comparing how much the levels were affected. I'm betting they got lower, partly because your age is listed as 19. you had a teenage libido before you started, and now you have an old man libido. does that sound right? I also suspect that 1-testosterone interacts with prolactin, which may account for loss of libido as well.

[armz_ha]

[QUOTE=the_invince]1-ad lowers libido because it supresses testosterone,(1-testosterone is not testosterone; it's a totally different hormone), 4ad increases libido, because it coverts to testosterone.

aw I see now, tnx man; I always wanted to know that but nobody answered-to your question, yes I have a sex drive of a little baby...

I don't think I'll get into 2 much details on this as I might get flamed for it, pm if you think you could help me out bro, tnx alot...

[protein_farts]

1-ad lowers libido because it supresses testosterone,(1-testosterone is not testosterone; it's a totally different hormone), 4ad increases libido, because it converts to testosterone.

very interesting. So, could the 1-testosterone probably be the cause of users low sex drive then? Could you check for 1-testosterone in blood tests:confused::)

[bobcat]

very interesting. So, could the 1-testosterone probably be the cause of users low sex drive then? Could you check for 1-testosterone in blood tests:confused::)

Can you check for deca-durabolin in blood tests? No. Same applies to 1-test.

[the_invince]

very interesting. So, could the 1-testosterone probably be the cause of users low sex drive then? Could you check for 1-testosterone in blood tests:confused::)

I think you confused what I said. 1-testosterone is not the hormone testosterone, it is a hormone that has been called dihydroboldenone, it suppresses natural testosterone through negative feedback. low testosterone levels are one cause of low sex drive, especially in teenagers, since teenage libido is connected to teenage testosterone levels.

[vanbiberjr]

Well anyways, my testosterone levels are very good and I have tried nolvadex and 6-xoxo- doesn't do a thing.

I just wanted an answer to why 1-ad causes low libido while 4-ad increases it. If I didn't wanna know, I wouldn't have asked...:rolleyes:

6-OXO did wonders for me. i was on bigger than needed doses of 1-AD, and afterwards felt the effects on the off-cycle. i also have a naturally high test level and when i started on 6-OXO, within 1-2 weeks was back shagging like a weasel.
1-AD + 4-AD is a good stack for the reasons mentioned in previous posts. afterwards, zinc/ZMA supps are good to look into because of their effect on natural test production "jump-start". also arginine for blood and vascularity. mushrooms are a good food source for zinc.

[armz_ha]

6-OXO did wonders for me. i was on bigger than needed doses of 1-AD, and afterwards felt the effects on the off-cycle. i also have a naturally high test level and when i started on 6-OXO, within 1-2 weeks was back shagging like a weasel.
1-AD + 4-AD is a good stack for the reasons mentioned in previous posts. afterwards, zinc/ZMA supps are good to look into because of their effect on natural test production "jump-start". also arginine for blood and vascularity. mushrooms are a good food source for zinc.

I am sure you get lots of zinc from salmon as well... :)
You're from Japan? It must be really easy for you to pack on the meat proteins- I plan to visit Japan sometime soon... :D

[protein_farts]

I think you confused what I said. 1-testosterone is not the hormone testosterone, it is a hormone that has been called dihydroboldenone, it suppresses natural testosterone through negative feedback. low testosterone levels are one cause of low sex drive, especially in teenagers, since teenage libido is connected to teenage testosterone levels.

^^ got it. :)

I think some users may experience longer term libido loss because 1 testosterone and 1-ad converts into DHT. I remember I read somewhere that DHT levels are really important to a healthy libido and potency.

[vanbiberjr]

I am sure you get lots of zinc from salmon as well...
You're from Japan? It must be really easy for you to pack on the meat proteins- I plan to visit Japan sometime soon...

yeah, japan's pretty cool. lots of fish, which is cool. sushi's good because there are so many different types of things they top the rice with, so there's a big variety of protein sources. alot of the restaraunts stay away from really fatty foods, so lean meat is not too hard to get out here. where in japan are you going?