Tribulus Terrestris

[BusterBob]

Does anyone know the "science" behind tribulus terrestris? Bodybuilding.com claims that it's "unknown" how it works, but that it does, which makes me very skeptical of it. Not to mention, no one I have talked to has reported any benefits from it at all. I'm just curious how they're able to market it if in fact there is no science behind it, other than what has been shown in rats. Any theories are appreciated.

[thelast10]

I Beleive it works by increasing luteinizing hormone output

[Vitamin S]

Exactly, there's no mistery to it. Higher LH levels mean potentially higher test levels.

[shpongled]

Originally posted by Vitamin S
Exactly, there's no mistery to it. Higher LH levels mean potentially higher test levels.

The mechanism of action is not well established. There are two theories:

1. Increases LH (not known exactly how)

2. The active ingredient is a prohormone to DHEA

If the latter is the case, people using it for PCT are shooting themselves in the foot.

[RippedUp]

I remember reading somewhere that tribulus also had an effect on NO levels or the pelvic muscle - thus enhanced erections.

[jhov]

Originally posted by RippedUp
I remember reading somewhere that tribulus also had an effect on NO levels or the pelvic muscle - thus enhanced erections.
I read a study on this but I dunno where I got it from. Someone posted it on another board a while back and I saved it but I dunno whom anymore. Please, anyone clarify if you can and know where it might be from as I would like to give credit if possible! I thought it might be from Dante on AL but I am not sure.

Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.

Adaikan PG, Gauthaman K, Prasad RN, Ng SC.

Department of Obstetrics & Gynaecology, National University Hospital, National University of Singapore, Singapore. obgadaik@nus.edu.sg

INTRODUCTION: The objective of the present study was to investigate the effect of oral treatment of Tribulus terrestris (TT) extract on the isolated corpus cavernosal tissue of New Zealand white (NZW) rabbits and to determine the mechanism by which protodioscin (PTN), a constituent of the TT, exerts its pharmacological effects. MATERIALS AND METHODS: Twenty-four NZW rabbits were randomly assigned to 4 experimental groups of 6 each. Group I served as control. Groups II to IV were treated with the extract at different dose levels, i.e. 2.5 mg/kg, 5 mg/kg and 10 mg/kg body weight, respectively. The TT extract was administered orally, once daily, for a period of 8 weeks. The rabbits were then sacrificed and their penile tissue isolated to evaluate the responses to both contracting and relaxing pharmacological agents and electrical field stimulation (EFS). RESULTS: PTN on its own had no effect on the isolated corpus cavernosal strips. The relaxant responses to EFS, acetylcholine and nitroglycerin in noradrenaline precontracted tissues from treated groups showed an increase in relaxation of a concentration dependent nature compared to that of the tissues from control group. However, the contractile, anti-erectile response of corpus cavernosal tissue to noradrenaline and histamine showed no significant change between the treatment and the control groups. CONCLUSIONS: The relaxant responses to acetylcholine, nitroglycerin and EFS by more than 10%, 24% and 10% respectively compared to their control values and the lack of such effect on the contractile response to noradrenaline and histamine indicate that PTN has a proerectile activity. The enhanced relaxant effect observed is probably due to increase in the release of nitric oxide from the endothelium and nitrergic nerve endings, which may account for its claims as an aphrodisiac. However, further study is needed to clarify the precise mechanism of its action.

peace
J

[jhov]

Originally posted by shpongled
The mechanism of action is not well established. There are two theories:

1. Increases LH (not known exactly how)

2. The active ingredient is a prohormone to DHEA

If the latter is the case, people using it for PCT are shooting themselves in the foot.
Shpongled,
do you have any references for the second point you made? I would love to read them. Thanks:)
peace
J

[buddha]

Originally posted by jhov
Shpongled,
do you have any references for the second point you made? I would love to read them. Thanks:)
peace
J

Here's one:

A. Adimoelja and P.G. Adaikan , Protodioscin from herbal plant Tribulus terrestris L. improves male sexual functions possibly via DHEA. International Journal of Impotence Research 9 1 (1997), p. S64.

That article above is referenced in:

Life Sci. 2002 Aug 9;71(12):1385-96. Related Articles, Links

Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.

Gauthaman K, Adaikan PG, Prasad RN.

[buddha]

Int J Androl. 2000;23 Suppl 2:82-4. Related Articles, Links

Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.

Adimoelja A.

School of medicine 'Hang Tuah' University, Teaching and Naval Hospital,Surabaya, Indonesia.

Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have developed from traditional herbs. Phytochemicals focus their mechanism of healing action to the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscine to DHEA (De-Hydro-Epi-Androsterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component Protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent results found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.

[jhov]

Originally posted by buddha
Int J Androl. 2000;23 Suppl 2:82-4. Related Articles, Links

Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.

Adimoelja A.

School of medicine 'Hang Tuah' University, Teaching and Naval Hospital,Surabaya, Indonesia.

Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have developed from traditional herbs. Phytochemicals focus their mechanism of healing action to the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscine to DHEA (De-Hydro-Epi-Androsterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component Protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent results found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.
Wow, very ineresting indeed! Thanks Buddha!
I guess the mod on abcbodybuilding may have had a point afterall!;):)
peace
J

[Bracken]

Originally posted by jhov
I guess the mod on abcbodybuilding may have had a point afterall!;):)
peace
J

!!

Come on now, that's crazy talk! :mad:

:D :D

[willie]

Originally posted by jhov
Wow, very ineresting indeed! Thanks Buddha!
I guess the mod on abcbodybuilding may have had a point afterall!;):)
peace
J

ever seen the new drug Ezyte, and smilin' bob....the male enhancement pill....it's not a drug at all, it's an over the counter herbal remedy.One of it's main ingredents is tribulus....