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older-than-dirt
02-04-2004, 08:55 AM
Does anyone know of any negative effects on results if you take advil after your workout ?

motorhall
02-04-2004, 12:06 PM
I thought that ibuprofen was an assumed part of the daily diet for everyone in this forum! :)

It's an anti-inflammatory, so if I tweak something during a workout it's ice and ibuprofen for me immediately afterwards. I did have a doctor tell me to not take it for more than three days in a row, though. Not sure what the consequences or effects are if you go beyond that.

Original Poster
02-04-2004, 12:55 PM
It inhibits protein synthesis.


http://forum.bodybuilding.com/showthread.php?s=&threadid=203382&highlight=ibuprofen

http://forum.bodybuilding.com/showthread.php?s=&threadid=162037&highlight=ibuprofen


also.......


Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.

Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.

Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA. trappetodda@uams.edu

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.




Me, I say take it only if really necessary and do not take it every day or after every WO for long durations........as the toxicity to the liver is pretty high.


-- Chi

Dutchman
02-04-2004, 04:56 PM
Dang, Chi_town, Its clear I've been all wrong with my approach over the last ten years or so. Here I've been taking 5 little ibuprophins about an hour before my workouts and just getting bigger and stronger each year. Maybe I'm just a freak???

Original Poster
02-04-2004, 05:26 PM
Yeah Dutchy your a freak, but of th highest quality ;)

No, it's not necessarily wrong, it's just not optimal for protein synthesis. ;)

People handle these substances quite differently actually. I am not sure how fast they would be absorbed and processed by the body....I would guess if you took them immediately PW.....it could have made it worse. LOL

Take them if you need to..but IMO...anything from serious pain killers to a simple aspirin should only be taken when really needed.and not as standard practice.

If it worked for you Dutchy, I can't knock it......for you


-- Chi

ojs
02-04-2004, 05:36 PM
Originally posted by Dutchman
Dang, Chi_town, Its clear I've been all wrong with my approach over the last ten years or so. Here I've been taking 5 little ibuprophins about an hour before my workouts and just getting bigger and stronger each year. Maybe I'm just a freak??? You don't need to be a freak. It's all a game of net gains. There are very few rules really. Mucho trade-offs work. If you do one thing AGAINST and that allows you to do the FOR even better, you'll grow. ..... it's all about net gains.

Dutchman
02-04-2004, 07:36 PM
That makes sence ojs. I am allergic to things like glucosamine (very bad reactions...like eating shrimp!!!). Hence I'm limited in what I can take for my aging joints. The ibuprophin kills the pain and allows me to give 110% to every set so I can leave everything I have in the gym. I load up on glutamine post workout and together that's how I get the old bod through another day!

Chi_town is probably right about the protein synthesis tie-in. It just seems to me like my body responds well to certain stimuli and my approach is personally successful.

ojs
02-04-2004, 07:51 PM
2000mg acetaminophen + 100mg diphenhydramineHCL before bed for the 3-4 days following leg day and 2 days following back day. Otherwise I can't sleep from the pain.

goatscrot
02-05-2004, 04:23 AM
Just a couple things:
In this particular study, they were taking the MAX daily recommended dose of ibuprofen or acetominophen. I'd venture to say most guys coming home from the gym with an ache or pain aren't popping 1200 mg worth of advil. I'd advise to take sparingly and only if really needed. But if you have to take one or two advils once or twice a week, i'd doubt you'd see much negative influence in muscle or strength gains.

do not take it every day or after every WO for long durations........as the toxicity to the liver is pretty high.
for acetominophen (tylenol), not for ibuprofen, which is metabolized through the kidneys.