Liver adaptations to supercompensation /depletion?

[coals]

Sorry if this has been asked, i searched and failed.

Muscle supposedly adapts to some forms of training by increasing the amount of glycogen it holds when full, especially after being fully depleted.


Can the liver theoretically do the same?

If i'm practicing intermittent fasting where the liver is , on a daily basis, more or less depleted and refilled. Would doing something like this combined with glycogen depletions and supercompensation (as per UD2.0 diet) induce an overall greater "max" liver glycogen? Or is that something entirely dependant on actual liver size/genetics?


Edit:

I found this study that sheds some light on whether or not liver CAN supercompensate:

http://jap.physiology.org/cgi/content/full/82/1/342


CHO loading is affected by a number of factors (e.g., the degree and method of glycogen depletion and the timing, amount, type, and form of ingested CHO). These factors, in turn, affect the rate and degree of muscle glycogen supercompensation. CHO loading can also produce supercompensation of liver glycogen; however, unlike muscle glycogen, liver glycogen can be converted to free glucose by the enzyme glucose-6-phosphatase (EC 3.1.3.9) and released to the blood (12). Under resting fed conditions, supercompensated liver glycogen will return to normal levels within 2 days (12). Under resting fasting conditions, normal liver glycogen stores become severely depleted after 16-24 h (12).

No mention of whether or not the liver will adapt to continuously doing this however.

[thegymbum]

Very interesting topic.

My initial thought on the subject is that it wouldn't be likely to occur. One of the proposed mechanisms behind glycogen supercompensation in muscle is the increased GLUT4, which leads to increased glucose uptake and thus increased glycogen synthase stimulation. However, liver does not express GLUT4, so under the same conditions, wouldn't necessarily take up glucose in excess of normal.

I'm off to do a little digging on the topic, though ;)

[coals]

Very interesting topic.

My initial thought on the subject is that it wouldn't be likely to occur. One of the proposed mechanisms behind glycogen supercompensation in muscle is the increased GLUT4, which leads to increased glucose uptake and thus increased glycogen synthase stimulation. However, liver does not express GLUT4, so under the same conditions, wouldn't necessarily take up glucose in excess of normal.

I'm off to do a little digging on the topic, though ;)

Thanks for response! Everytime i ask questions in advanced nutrition in ever get responses (lol in after serious questions).

Although the liver doesn't express Glut4 , the study i linked shows that it can supercompensate to a small degree. Other studies i've seen mention the liver going slightly higher above normal under the right conditions.

The real meat of the question is thus:

If the muscle can adapt to the type of training that stresses it's energetic/sarcoplasmic components by increasing it's overall maximum storage of glycogen, could the liver do the same? It would probably depend on the mechanism of glycogen storage in the liver... it's a tough question i know. Reps for good answers though.

I was thinking about how I IF everyday and how i'm currently on the UD2.0 diet by Lyle Mcdonald which kinda revolves around the mechanism behind depletion followed by supercompensation. Got me thinking about the liver and how i'm getting close to depleting liver glycogen on a daily basis by fasting most of the day.