Would depleting brain glucose deplete overall glycogen stores?

[adrenergic]

Since the brain uses about 120 Gs of glucose per day, do you think that depleting the brain's glucose stores would cause it to break down glycogen stores to replenish it's glucose levels? I'm thinking that's a big yes but it may not be as simple as that. What brought me onto this question was a little discussion of ketosis in the WD thread. I also remembered hearing something about THC depleting glucose stores in the brain. I researched it out found a few studies confirming the THC thing. Also, I don't want it to sound like I'm saying something like "will smoking weed get me ripped?", I'm not, this is purely curiosity.


If anyone wants i'll give links to studies.

[DR_P]

i think that glycogen stores are a much lesser issue (they get empty within 1-2 days) than increased gluconeogenesis from amino acid breakdown. moreover, within a few days (up to 1-2 weeks), CNS is getting used to low blood glucose levels and starts to utilise ketone bodies as primary energy source. the transition between this fuel switch is however poften painful as it is often accompanied by noticable oscillations of cognitive performance.

[Emma-Leigh]

Since the brain uses about 120 Gs of glucose per day, do you think that depleting the brain's glucose stores would cause it to break down glycogen stores to replenish it's glucose levels? I'm thinking that's a big yes but it may not be as simple as that. What brought me onto this question was a little discussion of ketosis in the WD thread. I also remembered hearing something about THC depleting glucose stores in the brain. I researched it out found a few studies confirming the THC thing. Also, I don't want it to sound like I'm saying something like "will smoking weed get me ripped?", I'm not, this is purely curiosity.


If anyone wants i'll give links to studies.
Not sure what exactly you are asking but:

The brain doesn't 'store' glucose - it is dependant on blood glucose as maintained by (primarily) liver glycogen + incoming food...

Liver glycogen stores deplete at a rate dependant on incoming glucose + overall activity.... But are usually depleted after 12-24 hrs - and they are broken down as a response to fasting (lower blood glucose = release of hormones that stimulate glycogenolysis).

Muscle glycogen can not be used to restore total body glucose, thus - once stores in the liver are gone, you don't get more from other areas and energy must be created from other sources.

Amino acids and, to a limited extent, glycerol from fats can be used to make glucose to help with daily functioning.

Amino acids and fatty acids can also go to create ketones which can be used by the brain.

Brain adaptation to ketones can occur as quickly as 72 hrs.... But can take longer as well.

As stated above - this transition period sucks donkeys...

[stackinweights]

Not sure what exactly you are asking but:

The brain doesn't 'store' glucose - it is dependant on blood glucose as maintained by (primarily) liver glycogen + incoming food...

Liver glycogen stores deplete at a rate dependant on incoming glucose + overall activity.... But are usually depleted after 12-24 hrs - and they are broken down as a response to fasting (lower blood glucose = release of hormones that stimulate glycogenolysis).

Muscle glycogen can not be used to restore total body glucose, thus - once stores in the liver are gone, you don't get more from other areas and energy must be created from other sources.

Amino acids and, to a limited extent, glycerol from fats can be used to make glucose to help with daily functioning.

Amino acids and fatty acids can also go to create ketones which can be used by the brain.

Brain adaptation to ketones can occur as quickly as 72 hrs.... But can take longer as well.

As stated above - this transition period sucks donkeys...

Ditto.

[adrenergic]

Since THC increases brain glucose metabolism, could it be used as a way to speed glycogen depletion noticeably since the brain uses so much glucose? That's what I was asking...

[Emma-Leigh]

Since THC increases brain glucose metabolism, could it be used as a way to speed glycogen depletion noticeably since the brain uses so much glucose? That's what I was asking...
No.

Firstly - you get a decreased BASAL glucose metabolism in some areas of the brain (eg: cerebellum)... The increase is only seen in specific areas of the brain (eg: basal ganglion) and usually only WHEN using (esp in chronic users)....


More importantly - You'll (likely) ruin your brain chemistry full stop. At 16 yrs your neural connections are only just being 'pruned' - and THC + changing testosterone and other neurochemicals = a recipe for abnormality. In many people this = an increased risk for things such as schizophrenia. And, well, not only will this mental illness ruin your life in general, but anti-psychotic medication = metabolic syndrome = man boobies.

Additionally - your body composition will likely be negatively effected through many other mechanisms - including very simple things like: munchies + disinhibition = pizza.... :p But also things like decreased psychomotor activity (=> decreased total body energy expenditure) and also a deterioration in your general health (eg: lung physiology via inhalation of smoke).

Smoking weed = not smart.

[adrenergic]

No.

Firstly - you get a decreased BASAL glucose metabolism in some areas of the brain (eg: cerebellum)... The increase is only seen in specific areas of the brain (eg: basal ganglion) and usually only WHEN using (esp in chronic users)....


More importantly - You'll (likely) ruin your brain chemistry full stop. At 16 yrs your neural connections are only just being 'pruned' - and THC + changing testosterone and other neurochemicals = a recipe for abnormality. In many people this = an increased risk for things such as schizophrenia. And, well, not only will this mental illness ruin your life in general, but anti-psychotic medication = metabolic syndrome = man boobies.

Additionally - your body composition will likely be negatively effected through many other mechanisms - including very simple things like: munchies + disinhibition = pizza.... :p But also things like decreased psychomotor activity (=> decreased total body energy expenditure) and also a deterioration in your general health (eg: lung physiology via inhalation of smoke).

Smoking weed = not smart.


Lol yeah, I don't smoke weed but, I was curious about this and had to ask.


Thanks for the clarification

But also on a small note, I was thinking more along the lines of the effects of pure THC, not the result of smoking a joint.

[KLMARB]

Hepatic gluconeogenesis is the key...besides ketone utilization...

[jvaughan08]

Since the brain uses about 120 Gs of glucose per day, do you think that depleting the brain's glucose stores would cause it to break down glycogen stores to replenish it's glucose levels? I'm thinking that's a big yes but it may not be as simple as that. What brought me onto this question was a little discussion of ketosis in the WD thread. I also remembered hearing something about THC depleting glucose stores in the brain. I researched it out found a few studies confirming the THC thing. Also, I don't want it to sound like I'm saying something like "will smoking weed get me ripped?", I'm not, this is purely curiosity.


If anyone wants i'll give links to studies.

dude you're 16 my man eat carbs and put on some lean mass, your metabolism will start to fly when u work out and put on mass cause you need more calories to maintain that muscle. glycogen is stored in your liver, and your brain and body uses glucose for energy and everyday functions. The theory is that weed can increase one's metabolic rate, hence the munchies. ketogenic diets are unhealthy, ya they lose weight fast, but when your body is in a ketogenic state it means the ph balance is uneven and your blood is literally acidic. i mean your young brotha, stay active, eat some healthy carbs, like fruit and whole grains. i mean i eat over 300 carbs a day and im lean so

[jvaughan08]

Since THC increases brain glucose metabolism, could it be used as a way to speed glycogen depletion noticeably since the brain uses so much glucose? That's what I was asking...

dude, glycogen stores dont make you fat man, it's just stored carbs your body needs to function properly. u need them to work out they give you energy.

[s.o.u.p]

it's a myth the keto depletes glycogen strores.

Over 50% of the protein we consume and 10% of the fat we consume is converted into glycogen.

[scoot557]

Over 50% of the protein we consume and 10% of the fat we consume is converted into glycogen.

Blanket statements, FTW!

[gekkoboy14]

it's a myth the keto depletes glycogen strores.

Over 50% of the protein we consume and 10% of the fat we consume is converted into glycogen.

is that so.... source me.
As above poster said, thats an extremely general statement to make. And there is a serious fundamental flaw with that response.

[KLMARB]

dude you're 16 my man eat carbs and put on some lean mass, your metabolism will start to fly when u work out and put on mass cause you need more calories to maintain that muscle. glycogen is stored in your liver, and your brain and body uses glucose for energy and everyday functions. The theory is that weed can increase one's metabolic rate, hence the munchies. ketogenic diets are unhealthy, ya they lose weight fast, but when your body is in a ketogenic state it means the ph balance is uneven and your blood is literally acidic. i mean your young brotha, stay active, eat some healthy carbs, like fruit and whole grains. i mean i eat over 300 carbs a day and im lean so

The lack of biochemical, as well as evolutionary knowledge in this post is fairly disturbing.

[gekkoboy14]

dude you're 16 my man eat carbs and put on some lean mass, your metabolism will start to fly when u work out and put on mass cause you need more calories to maintain that muscle. glycogen is stored in your liver, and your brain and body uses glucose for energy and everyday functions. The theory is that weed can increase one's metabolic rate, hence the munchies. ketogenic diets are unhealthy, ya they lose weight fast, but when your body is in a ketogenic state it means the ph balance is uneven and your blood is literally acidic. i mean your young brotha, stay active, eat some healthy carbs, like fruit and whole grains. i mean i eat over 300 carbs a day and im lean so

influx of dopamine is responsible for teh munchiez

[Autobody]

The lack of biochemical, as well as evolutionary knowledge in this post is fairly disturbing.

What do you mean? He said acidic! NOT GOOD ENUFF?