PDA

View Full Version : Scientists supposedly have found a way for ingested L-Carnitine to boost fat loss?



chosenone28
01-17-2009, 07:52 PM
Article is from supplementgenius.com


L-Carnitine
December 29, 2008

L-Carnitine is an amino acid found in all living tissue but more than 95% of the body?s total L-Carnitine stores are in the muscles. It?s a water-soluble amino acid synthesized in the liver from its amino acid precursors, lysine and methionine. L-Carnitine is marketed as a ?fat burner? that improves the body?s ability to utilize fat for energy. L-Carnitine does indeed transport fatty acids into the mitochondria (known as ?the powerhouse? of all cells), which enables muscle cells to utilize fats for energy.

Is Fat Loss Hindered Without L-Carnitine?

Cases of L-Carnitine deficiency were thought to be extremely rare because the normal diet provides ample amounts, which are sufficient to support this process. However, new research indicates that during intense exercise, muscle stores of L-Carnitine decrease by over 30%. This decrease has been directly linked to a reduction in fat utilization during exercise. Athletes who might stand to benefit from the supplementation of L-Carnitine are vegetarians and athletes in extreme endurance sports.

New L-Carnitine Research

Previous research in the 90s had shown that increasing the amount of ingested L-Carnitine does not increase levels of L-Carnitine in muscle tissue. As as a result, the rate or amount of fatty acids that can be converted into energy by the cell is unaffected. But what would happen if you COULD increase the level of L-Carnitine in muscle cells? Co-founder of EAS Anthony Almada (pictured with me and my greasy forehead on the left) says that British researchers have found a way to do this. If this is possible, watch for L-Carnitine to make a comeback in 2009.


Me: Does anyone know what study this EAS co-founder is talking about? I am interested because one of the only supplements I use is NOW L-Carnitine capsules post-workout.

in10city
01-18-2009, 02:12 AM
It's actually old news. Elevated insulin plays a role in uptake.

http://jcem.endojournals.org/cgi/content/full/91/12/5013

There may some additional literature on the propionyl form with this regard but I leave this up to the astute reader to follow up on.

chosenone28
01-18-2009, 05:47 AM
Thanks for the article.

Blindead
01-18-2009, 01:17 PM
Doesn't elevated insulin pretty much help with uptake of everything?

Phosphate bond
01-18-2009, 06:40 PM
It's actually old news. Elevated insulin plays a role in uptake.

http://jcem.endojournals.org/cgi/content/full/91/12/5013

There may some additional literature on the propionyl form with this regard but I leave this up to the astute reader to follow up on.

http://jap.physiology.org/cgi/content/full/102/3/1065

Here is the other study that followed that one (Sponsored by Lonza corporation)

I think the fact carnitine has a specific insulin transporter is interesting. The findings involving decreased substrate level phosphorylation and increased non-oxidative glucose disposal because of a 15% muscle carnitine increase are even more interesting. However, I'll bet in a cumulative sense having sufficient micronutrients and anti-oxidants is going to be more important (for someone exercising).

Phosphate bond
01-18-2009, 09:37 PM
Another review article by the same guys in the first two studies.

http://jp.physoc.org/cgi/content/full/581/2/431

Ted Nugent
02-03-2009, 08:26 AM
does all this mean that supplementing with carnitine will actually have an effect or should i not waste the money and buy some more eggs?

johnnyironboard
02-12-2009, 01:59 PM
I've used Carnitine for a long time and it doesn't help (me) with fat loss- I take it for a healthy heart along with CoQ10.

I know guys that swear by the injections for fat loss.

Black_Spit
02-15-2009, 05:41 PM
Doesn't elevated insulin pretty much help with uptake of everything?

No.

In fact, it blunts the effects of many stimulants such as Yohimbine hcl and caffeine.

jeremyleinen
03-01-2009, 07:10 PM
I've used Carnitine for a long time and it doesn't help (me) with fat loss- I take it for a healthy heart along with CoQ10.

I know guys that swear by the injections for fat loss.

injectable l-carnitine apparently is entirely different from the pills as far as bio-availability goes. I wouldn't mind getting ahold of some of that stuff.

_muscles_
09-01-2009, 12:48 AM
anyone know how this is typically run? How many mgs per day and how often do you have to inject it? Also what are some sites to purchase it from for my horse? It's totally legal so i thought i would ask

rob1992
09-24-2009, 05:12 AM
does all this mean that supplementing with carnitine will actually have an effect or should i not waste the money and buy some more eggs?

anyone answer this?